DNA vaccines for fish: Review and perspectives on correlates of protection
Recently in 2016, the European Medicines Agency (EMA) recommended granting a marketing authorization in the EU for “Clynav,” a DNA vaccine against salmon pancreas disease (salmonid alphavirus‐3). Generally, DNA vaccines induce both early and late immune responses in fish that may be protective again...
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| Veröffentlicht in: | Journal of fish diseases 2018-01, Vol.41 (1), p.1-9 |
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| description | Recently in 2016, the European Medicines Agency (EMA) recommended granting a marketing authorization in the EU for “Clynav,” a DNA vaccine against salmon pancreas disease (salmonid alphavirus‐3). Generally, DNA vaccines induce both early and late immune responses in fish that may be protective against disease. Several transcriptomic approaches have been performed to map immunome profiles following DNA vaccination, but the precise immune mechanism(s) that is responsible for protection is not known, although reasonable suggestions have been made. The current review includes an overview on main transcriptomic findings from microarray experiments after DNA vaccination against VHSV, IHNV, HIRRV and IPNV—with considerations of what can be considered as correlates of protection (CoP) or merely a surrogate of protection. Identification and use of correlates of protection (COPs) may be a strategic tool for accelerated and targeted vaccine design, testing and licensure. General rules on what can be considered as CoPs can be extracted from past knowledge on protective immune responses following vaccination that induced protection. Lastly, there will be an overview on non‐viral molecular adjuvants that have been exploited to obtain higher vaccine potencies and efficacies. |
| doi_str_mv | 10.1111/jfd.12727 |
| format | Article |
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Generally, DNA vaccines induce both early and late immune responses in fish that may be protective against disease. Several transcriptomic approaches have been performed to map immunome profiles following DNA vaccination, but the precise immune mechanism(s) that is responsible for protection is not known, although reasonable suggestions have been made. The current review includes an overview on main transcriptomic findings from microarray experiments after DNA vaccination against VHSV, IHNV, HIRRV and IPNV—with considerations of what can be considered as correlates of protection (CoP) or merely a surrogate of protection. Identification and use of correlates of protection (COPs) may be a strategic tool for accelerated and targeted vaccine design, testing and licensure. General rules on what can be considered as CoPs can be extracted from past knowledge on protective immune responses following vaccination that induced protection. 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Lastly, there will be an overview on non‐viral molecular adjuvants that have been exploited to obtain higher vaccine potencies and efficacies.</description><subject>Adjuvants</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Agriculture and fishery disciplines: 900</subject><subject>Animals</subject><subject>aquaculture</subject><subject>correlates of protection</subject><subject>Correlation</subject><subject>Deoxyribonucleic acid</subject><subject>Disease control</subject><subject>DNA</subject><subject>DNA microarrays</subject><subject>DNA vaccines</subject><subject>Exploitation</subject><subject>Fish</subject><subject>Fish Diseases - prevention & control</subject><subject>Fish Diseases - virology</subject><subject>Fish health: 923</subject><subject>Fisheries science: 920</subject><subject>Fishes</subject><subject>Fiskehelse: 923</subject><subject>Fiskerifag: 920</subject><subject>Freshwater fishes</subject><subject>Immune response</subject><subject>Immunization</subject><subject>Landbruks- og Fiskerifag: 900</subject><subject>Marketing</subject><subject>Pancreas</subject><subject>Profiles</subject><subject>Protection</subject><subject>RNA Virus Infections</subject><subject>RNA Viruses - immunology</subject><subject>Salmon</subject><subject>Vaccination</subject><subject>Vaccination - veterinary</subject><subject>Vaccines</subject><subject>Vaccines, DNA - immunology</subject><subject>VDP</subject><subject>Viral Vaccines - immunology</subject><subject>Viruses</subject><issn>0140-7775</issn><issn>1365-2761</issn><issn>1365-2761</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>3HK</sourceid><recordid>eNp10UtLAzEQB_AgitbHwS-gC170sJrJO96K9YkoiJ5D3M1iynZTk22l397UqgfBXIaQH_8ZMgjtAz6FfM7GTX0KRBK5hgZABS-JFLCOBhgYLqWUfAttpzTGGCQHsYm2iMaCYQ0DdDd6GBZzW1W-c6loQiwan97Oiyc39-6jsF1dTF1MU1f1fp5F6IoqxOha2y9vTTGNoV8-hm4XbTS2TW7vu-6gl6vL54ub8v7x-vZieF9WHJQsNVtW9qpJLSW2VAiqGiKwqmsOvFYEKqWlZQ3ThBKOmdZMA6m5lIpTBXQHHa5yq-hT7zvThWgNYEylAUqBZHG8Enm495lLvZn4VLm2tZ0Ls2RAc46FyjbToz90HGaxy_NnJSUwprTI6uSnZUgpusZMo5_YuMhtzXIFJq_AfK0g24PvxNnrxNW_8ufPMzhbgQ_fusX_SebuarSK_AR384p-</recordid><startdate>201801</startdate><enddate>201801</enddate><creator>Dalmo, R A</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TN</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H94</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>3HK</scope><orcidid>https://orcid.org/0000-0002-6181-9859</orcidid></search><sort><creationdate>201801</creationdate><title>DNA vaccines for fish: Review and perspectives on correlates of protection</title><author>Dalmo, R A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5187-94c5184b92d770a36638f2608dd515d821c897a4f49232504994912d577853813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adjuvants</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Agriculture and fishery disciplines: 900</topic><topic>Animals</topic><topic>aquaculture</topic><topic>correlates of protection</topic><topic>Correlation</topic><topic>Deoxyribonucleic acid</topic><topic>Disease control</topic><topic>DNA</topic><topic>DNA microarrays</topic><topic>DNA vaccines</topic><topic>Exploitation</topic><topic>Fish</topic><topic>Fish Diseases - prevention & control</topic><topic>Fish Diseases - virology</topic><topic>Fish health: 923</topic><topic>Fisheries science: 920</topic><topic>Fishes</topic><topic>Fiskehelse: 923</topic><topic>Fiskerifag: 920</topic><topic>Freshwater fishes</topic><topic>Immune response</topic><topic>Immunization</topic><topic>Landbruks- og Fiskerifag: 900</topic><topic>Marketing</topic><topic>Pancreas</topic><topic>Profiles</topic><topic>Protection</topic><topic>RNA Virus Infections</topic><topic>RNA Viruses - immunology</topic><topic>Salmon</topic><topic>Vaccination</topic><topic>Vaccination - veterinary</topic><topic>Vaccines</topic><topic>Vaccines, DNA - immunology</topic><topic>VDP</topic><topic>Viral Vaccines - immunology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dalmo, R A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Oceanic Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - 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Generally, DNA vaccines induce both early and late immune responses in fish that may be protective against disease. Several transcriptomic approaches have been performed to map immunome profiles following DNA vaccination, but the precise immune mechanism(s) that is responsible for protection is not known, although reasonable suggestions have been made. The current review includes an overview on main transcriptomic findings from microarray experiments after DNA vaccination against VHSV, IHNV, HIRRV and IPNV—with considerations of what can be considered as correlates of protection (CoP) or merely a surrogate of protection. Identification and use of correlates of protection (COPs) may be a strategic tool for accelerated and targeted vaccine design, testing and licensure. General rules on what can be considered as CoPs can be extracted from past knowledge on protective immune responses following vaccination that induced protection. 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| subjects | Adjuvants Adjuvants, Immunologic - pharmacology Agriculture and fishery disciplines: 900 Animals aquaculture correlates of protection Correlation Deoxyribonucleic acid Disease control DNA DNA microarrays DNA vaccines Exploitation Fish Fish Diseases - prevention & control Fish Diseases - virology Fish health: 923 Fisheries science: 920 Fishes Fiskehelse: 923 Fiskerifag: 920 Freshwater fishes Immune response Immunization Landbruks- og Fiskerifag: 900 Marketing Pancreas Profiles Protection RNA Virus Infections RNA Viruses - immunology Salmon Vaccination Vaccination - veterinary Vaccines Vaccines, DNA - immunology VDP Viral Vaccines - immunology Viruses |
| title | DNA vaccines for fish: Review and perspectives on correlates of protection |
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