Experiment research of cisplatin implants inhibiting transplantation tumor growth and regulating the expression of KLK7 and E-cad of tumor-bearing mice with gastric cancer
Objective: To study the influence of cisplatin implants on transplantation tumor growth and the expression of tissue kallikrein-7(KLK7) and E-cadherin(E-cad) in tumor-bearing mice with gastric cancer. Methods: BALB/c nude mice were collected as experimental animal and were randomly divided into mode...
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| Veröffentlicht in: | 亚太热带医药杂志：英文版 2016 (6), p.586-590 |
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| container_title | 亚太热带医药杂志：英文版 |
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| creator | Gui-Feng Zhuang Yan Tan Yuan-Zheng Yang Jie-Wei Zhang Jing Tang |
| description | Objective: To study the influence of cisplatin implants on transplantation tumor growth and the expression of tissue kallikrein-7(KLK7) and E-cadherin(E-cad) in tumor-bearing mice with gastric cancer. Methods: BALB/c nude mice were collected as experimental animal and were randomly divided into model control group(Group A), tail intravenous injection of cisplatin group(Group B), intratumor injection of cisplatin group(Group C) and cisplatin implants treatment group(Group D). After the drugs intervening, the weight and volume of transplantation tumors were measured on Day 20, Day 30 and Day 40 and serum and KLK7 and E-cad contents in transplanted tumor tissue were examined. Results: On Day 20, Day 30 and Day 40 after treatment, the weight and volume of transplantation tumors of tumorbearing mice in four groups were different(Group A > Group B > Group C > Group D). The contents of KLK-7 and E-cad in tumor tissue and serum of tumor-bearing mice in four groups were different(Group A > Group B > Group C > Group D in KLK-7) and(Group A < Group B < Group C < Group D in E-cad). The weight and volume, and KLK7 and E-cad contents of transplantation tumors in four groups were significant difference(P<0.05). Conclusion: Cisplatin implants can inhibit the growth of transplanted tumor tissue and down-regulated KLK7 expression and up-regulated E-cad expression of tumor-bearing mice with gastric cancer |
| format | Article |
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Methods: BALB/c nude mice were collected as experimental animal and were randomly divided into model control group(Group A), tail intravenous injection of cisplatin group(Group B), intratumor injection of cisplatin group(Group C) and cisplatin implants treatment group(Group D). After the drugs intervening, the weight and volume of transplantation tumors were measured on Day 20, Day 30 and Day 40 and serum and KLK7 and E-cad contents in transplanted tumor tissue were examined. Results: On Day 20, Day 30 and Day 40 after treatment, the weight and volume of transplantation tumors of tumorbearing mice in four groups were different(Group A > Group B > Group C > Group D). The contents of KLK-7 and E-cad in tumor tissue and serum of tumor-bearing mice in four groups were different(Group A > Group B > Group C > Group D in KLK-7) and(Group A < Group B < Group C < Group D in E-cad). The weight and volume, and KLK7 and E-cad contents of transplantation tumors in four groups were significant difference(P<0.05). Conclusion: Cisplatin implants can inhibit the growth of transplanted tumor tissue and down-regulated KLK7 expression and up-regulated E-cad expression of tumor-bearing mice with gastric cancer]]></description><identifier>ISSN: 1995-7645</identifier><identifier>EISSN: 2352-4146</identifier><language>eng</language><subject>cancer;Cisplatin ; Gastric ; implants;Tissue ; kallikrein-7;E-cadherin</subject><ispartof>亚太热带医药杂志：英文版, 2016 (6), p.586-590</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71792X/71792X.jpg</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids></links><search><creatorcontrib>Gui-Feng Zhuang Yan Tan Yuan-Zheng Yang Jie-Wei Zhang Jing Tang</creatorcontrib><title>Experiment research of cisplatin implants inhibiting transplantation tumor growth and regulating the expression of KLK7 and E-cad of tumor-bearing mice with gastric cancer</title><title>亚太热带医药杂志：英文版</title><addtitle>Asian Pacific Journal of Tropical Medicine</addtitle><description><![CDATA[Objective: To study the influence of cisplatin implants on transplantation tumor growth and the expression of tissue kallikrein-7(KLK7) and E-cadherin(E-cad) in tumor-bearing mice with gastric cancer. Methods: BALB/c nude mice were collected as experimental animal and were randomly divided into model control group(Group A), tail intravenous injection of cisplatin group(Group B), intratumor injection of cisplatin group(Group C) and cisplatin implants treatment group(Group D). After the drugs intervening, the weight and volume of transplantation tumors were measured on Day 20, Day 30 and Day 40 and serum and KLK7 and E-cad contents in transplanted tumor tissue were examined. Results: On Day 20, Day 30 and Day 40 after treatment, the weight and volume of transplantation tumors of tumorbearing mice in four groups were different(Group A > Group B > Group C > Group D). The contents of KLK-7 and E-cad in tumor tissue and serum of tumor-bearing mice in four groups were different(Group A > Group B > Group C > Group D in KLK-7) and(Group A < Group B < Group C < Group D in E-cad). The weight and volume, and KLK7 and E-cad contents of transplantation tumors in four groups were significant difference(P<0.05). Conclusion: Cisplatin implants can inhibit the growth of transplanted tumor tissue and down-regulated KLK7 expression and up-regulated E-cad expression of tumor-bearing mice with gastric cancer]]></description><subject>cancer;Cisplatin</subject><subject>Gastric</subject><subject>implants;Tissue</subject><subject>kallikrein-7;E-cadherin</subject><issn>1995-7645</issn><issn>2352-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqdj1FqwzAMhs3YYGHrHXQBQ5vYjf08Mgbd496L67q2RmNntku7M-2SU8JOMIGQ-Pm_X-iONW0nWy42YnvPmo3WkvdbIR_ZqpTPNVXXat13DfsZbpPLOLpYIbviTLYB0gkslulsKkbAkZZYC2AMeECSPNRsYllksqQI9TKmDD6naw1g4pGi_GXByRscuNtE4WW2UvbufdcvroFbc5yVhecHuj4TI1oHV6Qob0rNaMGaaF1-Zg8ncy5u9TefWPc6fLy8cRtS9F-E7id6xeTvvdJKqFZpuRZKaCmEmps22f2P-gUM_GoN</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Gui-Feng Zhuang Yan Tan Yuan-Zheng Yang Jie-Wei Zhang Jing Tang</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope></search><sort><creationdate>2016</creationdate><title>Experiment research of cisplatin implants inhibiting transplantation tumor growth and regulating the expression of KLK7 and E-cad of tumor-bearing mice with gastric cancer</title><author>Gui-Feng Zhuang Yan Tan Yuan-Zheng Yang Jie-Wei Zhang Jing Tang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-chongqing_primary_898482895048495448544849553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>cancer;Cisplatin</topic><topic>Gastric</topic><topic>implants;Tissue</topic><topic>kallikrein-7;E-cadherin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gui-Feng Zhuang Yan Tan Yuan-Zheng Yang Jie-Wei Zhang Jing Tang</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><jtitle>亚太热带医药杂志：英文版</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gui-Feng Zhuang Yan Tan Yuan-Zheng Yang Jie-Wei Zhang Jing Tang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experiment research of cisplatin implants inhibiting transplantation tumor growth and regulating the expression of KLK7 and E-cad of tumor-bearing mice with gastric cancer</atitle><jtitle>亚太热带医药杂志：英文版</jtitle><addtitle>Asian Pacific Journal of Tropical Medicine</addtitle><date>2016</date><risdate>2016</risdate><issue>6</issue><spage>586</spage><epage>590</epage><pages>586-590</pages><issn>1995-7645</issn><eissn>2352-4146</eissn><abstract><![CDATA[Objective: To study the influence of cisplatin implants on transplantation tumor growth and the expression of tissue kallikrein-7(KLK7) and E-cadherin(E-cad) in tumor-bearing mice with gastric cancer. Methods: BALB/c nude mice were collected as experimental animal and were randomly divided into model control group(Group A), tail intravenous injection of cisplatin group(Group B), intratumor injection of cisplatin group(Group C) and cisplatin implants treatment group(Group D). After the drugs intervening, the weight and volume of transplantation tumors were measured on Day 20, Day 30 and Day 40 and serum and KLK7 and E-cad contents in transplanted tumor tissue were examined. Results: On Day 20, Day 30 and Day 40 after treatment, the weight and volume of transplantation tumors of tumorbearing mice in four groups were different(Group A > Group B > Group C > Group D). The contents of KLK-7 and E-cad in tumor tissue and serum of tumor-bearing mice in four groups were different(Group A > Group B > Group C > Group D in KLK-7) and(Group A < Group B < Group C < Group D in E-cad). The weight and volume, and KLK7 and E-cad contents of transplantation tumors in four groups were significant difference(P<0.05). Conclusion: Cisplatin implants can inhibit the growth of transplanted tumor tissue and down-regulated KLK7 expression and up-regulated E-cad expression of tumor-bearing mice with gastric cancer]]></abstract></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1995-7645 |
| ispartof | 亚太热带医药杂志：英文版, 2016 (6), p.586-590 |
| issn | 1995-7645 2352-4146 |
| language | eng |
| recordid | cdi_chongqing_primary_89848289504849544854484955 |
| source | Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | cancer Cisplatin Gastric implants Tissue kallikrein-7 E-cadherin |
| title | Experiment research of cisplatin implants inhibiting transplantation tumor growth and regulating the expression of KLK7 and E-cad of tumor-bearing mice with gastric cancer |
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