BETA-THALASSEMIA MUTATIONS IN CHINESE SUBJECTS IDENTIFIED BY SYNTHETIC OLIGONUCLEOTIDES
<正> As most of the β-thalassemia mutations are point mutations, the oligonucleotides, specific for the β-thalassemia genes (β~T), can be synthesized to detect the mutations directly. Using synthetic oligonucleotides (nonadecamers) hemologous to the six β~T mutations as well as their no...
Gespeichert in:
| Veröffentlicht in: | 科学通报：英文版 1988 (10), p.879-880 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 880 |
|---|---|
| container_issue | 10 |
| container_start_page | 879 |
| container_title | 科学通报：英文版 |
| container_volume | |
| creator | 黄淑帧 曾溢滔 廖英华 张基增 简悦威 |
| description | <正> As most of the β-thalassemia mutations are point mutations, the oligonucleotides, specific for the β-thalassemia genes (β~T), can be synthesized to detect the mutations directly. Using synthetic oligonucleotides (nonadecamers) hemologous to the six β~T mutations as well as their normal counterparts as hybridization probes, DNAs from 10 β-thalassemia patients and their parents, living in Sichuan, Zhejiang, Guangxi and Hunan, were analysed. Of the 20 β~T chromosomes analysed to date, six different β- |
| format | Article |
| fullrecord | <record><control><sourceid>chongqing</sourceid><recordid>TN_cdi_chongqing_primary_74888487495756564948485051</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>74888487495756564948485051</cqvip_id><sourcerecordid>74888487495756564948485051</sourcerecordid><originalsourceid>FETCH-chongqing_primary_748884874957565649484850513</originalsourceid><addsrcrecordid>eNqdi0sOgjAURTvQRKPuoRsgKdBSOiz1KTVQBn3EOCLE-I3ih5G7l4ErcHRzTs4dkWnElAhUJOMJWfT9lTEWchVxJqdkmwHqAHNdaO-htJqWNWq0lfPUOmpy68AD9XW2AYODW4JDu7KwpNmO-p3DHNAaWhV2XbnaFFDh0Pg5GR_bW39Y_HZG4hWgyYP9-dGdXpfu1Dzfl3v7_jSSp2nKU8mVkCIRCVd8QMFEGP_3-gJEOD_p</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>BETA-THALASSEMIA MUTATIONS IN CHINESE SUBJECTS IDENTIFIED BY SYNTHETIC OLIGONUCLEOTIDES</title><source>Alma/SFX Local Collection</source><creator>黄淑帧 曾溢滔 廖英华 张基增 简悦威</creator><creatorcontrib>黄淑帧 曾溢滔 廖英华 张基增 简悦威</creatorcontrib><description>&lt;正&gt; As most of the β-thalassemia mutations are point mutations, the oligonucleotides, specific for the β-thalassemia genes (β~T), can be synthesized to detect the mutations directly. Using synthetic oligonucleotides (nonadecamers) hemologous to the six β~T mutations as well as their normal counterparts as hybridization probes, DNAs from 10 β-thalassemia patients and their parents, living in Sichuan, Zhejiang, Guangxi and Hunan, were analysed. Of the 20 β~T chromosomes analysed to date, six different β-</description><identifier>ISSN: 2095-9273</identifier><language>eng</language><subject>chromosomes;parents;analysed;probes;Hunan;ident;Codon</subject><ispartof>科学通报：英文版, 1988 (10), p.879-880</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/86894X/86894X.jpg</thumbnail><link.rule.ids>314,780,784,4022</link.rule.ids></links><search><creatorcontrib>黄淑帧 曾溢滔 廖英华 张基增 简悦威</creatorcontrib><title>BETA-THALASSEMIA MUTATIONS IN CHINESE SUBJECTS IDENTIFIED BY SYNTHETIC OLIGONUCLEOTIDES</title><title>科学通报：英文版</title><addtitle>Science Bulletin</addtitle><description>&lt;正&gt; As most of the β-thalassemia mutations are point mutations, the oligonucleotides, specific for the β-thalassemia genes (β~T), can be synthesized to detect the mutations directly. Using synthetic oligonucleotides (nonadecamers) hemologous to the six β~T mutations as well as their normal counterparts as hybridization probes, DNAs from 10 β-thalassemia patients and their parents, living in Sichuan, Zhejiang, Guangxi and Hunan, were analysed. Of the 20 β~T chromosomes analysed to date, six different β-</description><subject>chromosomes;parents;analysed;probes;Hunan;ident;Codon</subject><issn>2095-9273</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><recordid>eNqdi0sOgjAURTvQRKPuoRsgKdBSOiz1KTVQBn3EOCLE-I3ih5G7l4ErcHRzTs4dkWnElAhUJOMJWfT9lTEWchVxJqdkmwHqAHNdaO-htJqWNWq0lfPUOmpy68AD9XW2AYODW4JDu7KwpNmO-p3DHNAaWhV2XbnaFFDh0Pg5GR_bW39Y_HZG4hWgyYP9-dGdXpfu1Dzfl3v7_jSSp2nKU8mVkCIRCVd8QMFEGP_3-gJEOD_p</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>黄淑帧 曾溢滔 廖英华 张基增 简悦威</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope></search><sort><creationdate>1988</creationdate><title>BETA-THALASSEMIA MUTATIONS IN CHINESE SUBJECTS IDENTIFIED BY SYNTHETIC OLIGONUCLEOTIDES</title><author>黄淑帧 曾溢滔 廖英华 张基增 简悦威</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-chongqing_primary_748884874957565649484850513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>chromosomes;parents;analysed;probes;Hunan;ident;Codon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>黄淑帧 曾溢滔 廖英华 张基增 简悦威</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><jtitle>科学通报：英文版</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>黄淑帧 曾溢滔 廖英华 张基增 简悦威</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BETA-THALASSEMIA MUTATIONS IN CHINESE SUBJECTS IDENTIFIED BY SYNTHETIC OLIGONUCLEOTIDES</atitle><jtitle>科学通报：英文版</jtitle><addtitle>Science Bulletin</addtitle><date>1988</date><risdate>1988</risdate><issue>10</issue><spage>879</spage><epage>880</epage><pages>879-880</pages><issn>2095-9273</issn><abstract>&lt;正&gt; As most of the β-thalassemia mutations are point mutations, the oligonucleotides, specific for the β-thalassemia genes (β~T), can be synthesized to detect the mutations directly. Using synthetic oligonucleotides (nonadecamers) hemologous to the six β~T mutations as well as their normal counterparts as hybridization probes, DNAs from 10 β-thalassemia patients and their parents, living in Sichuan, Zhejiang, Guangxi and Hunan, were analysed. Of the 20 β~T chromosomes analysed to date, six different β-</abstract></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2095-9273 |
| ispartof | 科学通报：英文版, 1988 (10), p.879-880 |
| issn | 2095-9273 |
| language | eng |
| recordid | cdi_chongqing_primary_74888487495756564948485051 |
| source | Alma/SFX Local Collection |
| subjects | chromosomes parents analysed probes Hunan ident Codon |
| title | BETA-THALASSEMIA MUTATIONS IN CHINESE SUBJECTS IDENTIFIED BY SYNTHETIC OLIGONUCLEOTIDES |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T13%3A11%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-chongqing&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=BETA-THALASSEMIA%20MUTATIONS%20IN%20CHINESE%20SUBJECTS%20IDENTIFIED%20BY%20SYNTHETIC%20OLIGONUCLEOTIDES&rft.jtitle=%E7%A7%91%E5%AD%A6%E9%80%9A%E6%8A%A5%EF%BC%9A%E8%8B%B1%E6%96%87%E7%89%88&rft.au=%E9%BB%84%E6%B7%91%E5%B8%A7%20%E6%9B%BE%E6%BA%A2%E6%BB%94%20%E5%BB%96%E8%8B%B1%E5%8D%8E%20%E5%BC%A0%E5%9F%BA%E5%A2%9E%20%E7%AE%80%E6%82%A6%E5%A8%81&rft.date=1988&rft.issue=10&rft.spage=879&rft.epage=880&rft.pages=879-880&rft.issn=2095-9273&rft_id=info:doi/&rft_dat=%3Cchongqing%3E74888487495756564948485051%3C/chongqing%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_cqvip_id=74888487495756564948485051&rfr_iscdi=true |