Proton leakage is the mechanism for hematoporphyrin photosensitization-promoted inactivation of rat liver mitochondria
<正> The effects of hematoporphyrin photosensitization on the energy-transducing functions of isolated rat liver mitochondria have been studied. By using the measurements of the illumination time-and hematoporphyrin concentration-dependent variations of bioenergetical parameters of mito...
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| Veröffentlicht in: | 自然科学进展：英文版 1995 (4), p.28-36 |
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| container_title | 自然科学进展：英文版 |
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| creator | 周同庆 焦选茂 魏影允 刘树森 冯伟华 缪明永 |
| description | <正> The effects of hematoporphyrin photosensitization on the energy-transducing functions of isolated rat liver mitochondria have been studied. By using the measurements of the illumination time-and hematoporphyrin concentration-dependent variations of bioenergetical parameters of mitochondria, it is shown clearly that the photosensitization-promoted proton leakage of inner mitochondrial membrane, together with the resultant dissipation of proton electrochemical gradient, is the mechanism leading to the impairment of oxidative phosphorylation of mitochondria. |
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By using the measurements of the illumination time-and hematoporphyrin concentration-dependent variations of bioenergetical parameters of mitochondria, it is shown clearly that the photosensitization-promoted proton leakage of inner mitochondrial membrane, together with the resultant dissipation of proton electrochemical gradient, is the mechanism leading to the impairment of oxidative phosphorylation of mitochondria.</description><identifier>ISSN: 1002-0071</identifier><language>eng</language><subject>hematoporphyrin;photosensitization;mitochondria;singlet ; leakage ; oxygen;proton</subject><ispartof>自然科学进展：英文版, 1995 (4), p.28-36</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85882X/85882X.jpg</thumbnail><link.rule.ids>314,776,780,4009</link.rule.ids></links><search><creatorcontrib>周同庆;焦选茂;魏影允;刘树森;冯伟华;缪明永</creatorcontrib><title>Proton leakage is the mechanism for hematoporphyrin photosensitization-promoted inactivation of rat liver mitochondria</title><title>自然科学进展：英文版</title><addtitle>Progress in Natural Science</addtitle><description>&lt;正&gt; The effects of hematoporphyrin photosensitization on the energy-transducing functions of isolated rat liver mitochondria have been studied. By using the measurements of the illumination time-and hematoporphyrin concentration-dependent variations of bioenergetical parameters of mitochondria, it is shown clearly that the photosensitization-promoted proton leakage of inner mitochondrial membrane, together with the resultant dissipation of proton electrochemical gradient, is the mechanism leading to the impairment of oxidative phosphorylation of mitochondria.</description><subject>hematoporphyrin;photosensitization;mitochondria;singlet</subject><subject>leakage</subject><subject>oxygen;proton</subject><issn>1002-0071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNqVi7tOxEAMRacAiYXlH9yjSA77CKkRiJKCfmVlnYwhMx48VqTl62ERP0B1j47OvQirFvG-Qezaq3Bd6zuecd-twvJq6pphZvqgiUEqeGRIPETKUhOMahA5kWtRK_FkkqHEn0_lXMXli1w0N8U0qfMRJNPgsvxa0BGMHGZZ2CCJ6xA1H01oHS5Hmivf_u1NuHt-ent8ac7B9Cl5OhSTRHY67Hvsdt32oW_7fodbxM3mf_U3O_9RnA</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>周同庆;焦选茂;魏影允;刘树森;冯伟华;缪明永</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope></search><sort><creationdate>1995</creationdate><title>Proton leakage is the mechanism for hematoporphyrin photosensitization-promoted inactivation of rat liver mitochondria</title><author>周同庆;焦选茂;魏影允;刘树森;冯伟华;缪明永</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-chongqing_primary_6907574891995040033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>hematoporphyrin;photosensitization;mitochondria;singlet</topic><topic>leakage</topic><topic>oxygen;proton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>周同庆;焦选茂;魏影允;刘树森;冯伟华;缪明永</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><jtitle>自然科学进展：英文版</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>周同庆;焦选茂;魏影允;刘树森;冯伟华;缪明永</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proton leakage is the mechanism for hematoporphyrin photosensitization-promoted inactivation of rat liver mitochondria</atitle><jtitle>自然科学进展：英文版</jtitle><addtitle>Progress in Natural Science</addtitle><date>1995</date><risdate>1995</risdate><issue>4</issue><spage>28</spage><epage>36</epage><pages>28-36</pages><issn>1002-0071</issn><abstract>&lt;正&gt; The effects of hematoporphyrin photosensitization on the energy-transducing functions of isolated rat liver mitochondria have been studied. By using the measurements of the illumination time-and hematoporphyrin concentration-dependent variations of bioenergetical parameters of mitochondria, it is shown clearly that the photosensitization-promoted proton leakage of inner mitochondrial membrane, together with the resultant dissipation of proton electrochemical gradient, is the mechanism leading to the impairment of oxidative phosphorylation of mitochondria.</abstract></addata></record> |
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| identifier | ISSN: 1002-0071 |
| ispartof | 自然科学进展：英文版, 1995 (4), p.28-36 |
| issn | 1002-0071 |
| language | eng |
| recordid | cdi_chongqing_primary_690757489199504003 |
| source | Alma/SFX Local Collection |
| subjects | hematoporphyrin photosensitization mitochondria singlet leakage oxygen proton |
| title | Proton leakage is the mechanism for hematoporphyrin photosensitization-promoted inactivation of rat liver mitochondria |
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