Synthesis and Biological Evaluation of Gem-Difluoro- methylenated Statin Derivatives as Highly Potent HMG-CoA Reductase Inhibitors

HMG-CoA reductase inhibitors were widely used as lipid-lowing agents through effectively blocking the rate-limiting step of cholesterol biosynthesis. 8 analogs of Rosuvastatin were firstly prepared with different distance andfunctional group between the O5-hydroxyl group and terminal COOH group in t...

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Veröffentlicht in:	中国化学：英文版 2016 (8), p.801-808
1. Verfasser:	Zhao Zhao Jiaxin Cui Yan Yin Heng Zhang Yecheng Liu Rui Zeng Chao Fang Zhenpeng Kai ZhonghuaWang Fanhong Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	compounds derivatives docking gem-difluoromethylenated HMG-CoA hypercho-lesterolemia inhibitors molecular reductase statin
Online-Zugang:	Volltext
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