Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausa Chinese women

Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausa Chinese women

Growth differentiation factor 11 （GDF11） is an important circulating factor that regulates aging. However, the role of GDF11 in bone metabolism remains unclear. The present study was undertaken to investigate the relationship between serum GDF11 level, bone mass, and bone turnover markers in postmen...

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Veröffentlicht in:骨研究：英文 2016 (1), p.55-59
1. Verfasser: Yusi Chen Qi Guo Min Zhang Shumin Song Tonggui Quan Tiepeng Zhao Hongliang Li Lijuan Guo Tiejian Jiang Guangwei Wang
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妇女
清水
生长分化因子
绝经后
血清
逐步回归分析
骨密度
骨碱性磷酸酶
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description Growth differentiation factor 11 （GDF11） is an important circulating factor that regulates aging. However, the role of GDF11 in bone metabolism remains unclear. The present study was undertaken to investigate the relationship between serum GDF11 level, bone mass, and bone turnover markers in postmenopausal Chinese women. Serum GDF11 level, bone turnover biochemical markers, and bone mineral density （BMD） were determined in 169 postmenopausal Chinese women （47-78 years old）. GDF11 serum levels increased with aging. There were negative correlations between GDF11 and BMD at the various skeletal sites. After adjusting for age and body mass index （BMI）, the correlations remained statistically significant. In the multiple linear stepwise regression analysis, age or years since menopause, BMI, GDF11, and estradiol were independent predictors of BMD. A significant negative correlation between GDF11 and bone alkaline phosphatase （BAP） was identified and remained significant after adjusting for age and BMI. No signific
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subjects 妇女
清水
生长分化因子
绝经后
血清
逐步回归分析
骨密度
骨碱性磷酸酶
title Relationship of serum GDF11 levels with bone mineral density and bone turnover markers in postmenopausa Chinese women
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