有机阴离子转运多肽1B1遗传多态性与个体化用药

有机阴离子转运多肽1B1遗传多态性与个体化用药

有机阴离子转运多肽1B1（organic anion transporting polypeptide 1B1,OATP1B1）由SLCO1B1基因编码,对多种内源性物质及药物具有转运作用,其单核苷酸多态性对药物反应个体差异有重要影响。本文阐述了OATP1B1遗传多态性对他汀类药物、抗肿瘤药物及降糖药物等药代动力学及药效学的影响,以利于药物的合理应用及临床个体化用药。...

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Veröffentlicht in:	中国临床药理学与治疗学 2015, Vol.50 (12), p.1426-1433
1. Verfasser:	王晶郭成贤阳国平李金高袁洪周宏灏
Format:	Artikel
Sprache:	chi
Schlagworte:	SLCO1B1 个体化用药单核苷酸多态性（SNP）有机阴离子转运多肽1B1（OATP1B1）
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creator	王晶郭成贤阳国平李金高袁洪周宏灏
description	有机阴离子转运多肽1B1（organic anion transporting polypeptide 1B1,OATP1B1）由SLCO1B1基因编码,对多种内源性物质及药物具有转运作用,其单核苷酸多态性对药物反应个体差异有重要影响。本文阐述了OATP1B1遗传多态性对他汀类药物、抗肿瘤药物及降糖药物等药代动力学及药效学的影响,以利于药物的合理应用及临床个体化用药。
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subjects	SLCO1B1 个体化用药单核苷酸多态性（SNP）有机阴离子转运多肽1B1（OATP1B1）
title	有机阴离子转运多肽1B1遗传多态性与个体化用药
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