Identification of a novel HIV-1 intra-circulating recombinant form 01_AE in China: a descendant of the previously identified CRF01 AE transmission clusters I and 6

Dear Editors, Here, we report a novel HIV-1 intra-circulating recombinant form 01_AE (intra-CRF01_AE: CRF01-1AE/CRF01-6AE) composed of CRF01_AE transmission clusters 1 and 6, which was identified in a heterosexual male from Fujian, with one breakpoint observed in the vif gene. The CRF01_AE region I...

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Veröffentlicht in:中国科学:生命科学英文版 2015 (7), p.724-726
1. Verfasser: NING ChuanYi LI XingGuang TANG WeiMing ZHOU go CAI WeiPing TUCKER Joseph D
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description Dear Editors, Here, we report a novel HIV-1 intra-circulating recombinant form 01_AE (intra-CRF01_AE: CRF01-1AE/CRF01-6AE) composed of CRF01_AE transmission clusters 1 and 6, which was identified in a heterosexual male from Fujian, with one breakpoint observed in the vif gene. The CRF01_AE region I (HXB2: 868-5184) of the recombinant clustered with CRF01_AE transmission cluster 1, which is mainly circulating among injection drug users (IDUs) and heterosexuals in southern and southwestern China, with the support of a 100% bootstrap value. The CRF01_AE region II (HXB2: 5185-9605) of the recombinant clustered with CRF01_AE transmission cluster 6, which mainly prevails among heterosexuals in southern China, with the support of a 100% bootstrap value. To our knowledge, this is the first detection of a novel HIV-1 intra-CRF01_AE recombinant form (CRF01-1_AE/CRF01-6_ AE) in Fujian, China, which indicates ongoing active HIV-1 transmission among heter- osexuals in this region.
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The CRF01_AE region I (HXB2: 868-5184) of the recombinant clustered with CRF01_AE transmission cluster 1, which is mainly circulating among injection drug users (IDUs) and heterosexuals in southern and southwestern China, with the support of a 100% bootstrap value. The CRF01_AE region II (HXB2: 5185-9605) of the recombinant clustered with CRF01_AE transmission cluster 6, which mainly prevails among heterosexuals in southern China, with the support of a 100% bootstrap value. To our knowledge, this is the first detection of a novel HIV-1 intra-CRF01_AE recombinant form (CRF01-1_AE/CRF01-6_ AE) in Fujian, China, which indicates ongoing active HIV-1 transmission among heter- osexuals in this region.</description><identifier>ISSN: 1674-7305</identifier><identifier>EISSN: 1869-1889</identifier><language>eng</language><subject>HIV-1 ; 传输集群 ; 后代 ; 识别 ; 重组</subject><ispartof>中国科学:生命科学英文版, 2015 (7), p.724-726</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/60112X/60112X.jpg</thumbnail><link.rule.ids>315,781,785,4025</link.rule.ids></links><search><creatorcontrib>NING ChuanYi LI XingGuang TANG WeiMing ZHOU go CAI WeiPing TUCKER Joseph D</creatorcontrib><title>Identification of a novel HIV-1 intra-circulating recombinant form 01_AE in China: a descendant of the previously identified CRF01 AE transmission clusters I and 6</title><title>中国科学:生命科学英文版</title><description>Dear Editors, Here, we report a novel HIV-1 intra-circulating recombinant form 01_AE (intra-CRF01_AE: CRF01-1AE/CRF01-6AE) composed of CRF01_AE transmission clusters 1 and 6, which was identified in a heterosexual male from Fujian, with one breakpoint observed in the vif gene. The CRF01_AE region I (HXB2: 868-5184) of the recombinant clustered with CRF01_AE transmission cluster 1, which is mainly circulating among injection drug users (IDUs) and heterosexuals in southern and southwestern China, with the support of a 100% bootstrap value. The CRF01_AE region II (HXB2: 5185-9605) of the recombinant clustered with CRF01_AE transmission cluster 6, which mainly prevails among heterosexuals in southern China, with the support of a 100% bootstrap value. 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subjects HIV-1
传输集群
后代
识别
重组
title Identification of a novel HIV-1 intra-circulating recombinant form 01_AE in China: a descendant of the previously identified CRF01 AE transmission clusters I and 6
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