Sinomenine derivatives with embedment of nitrogen-containing heterocycles exhibiting potent TNF-a inhibitory activity

Inhibitory effect on tumor necrosis factor-c~ （TNF-c0 production by sinomenine derivatives with embedment of small drug-like nitrogen hetereocyclic moieties has been studied in this work. Several new sinomenine derivatives having chlorophenyl sub- stituent have been found to exhibit much more potent...

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Veröffentlicht in:	中国科学：化学英文版 2012, Vol.55 (12), p.2537-2547
1. Verfasser:	WANG Meng MA LiYan LOU YangTong BIAN Chao ZHOU TingTing ZHOU HaiBin LIAO HongZe MA Zhao YIN DongSheng CHEN AiZhong WANG ShaoZhong YANG ZhenYu SUN Bing YAO ZhuJun
Format:	Artikel
Sprache:	eng
Schlagworte:	TNF-α 含氮杂环 埋置 抑制作用 抑制活性 肿瘤坏死因子 衍生物 青藤碱
Online-Zugang:	Volltext
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