NQ01 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia
Objective： To investigate the relationship between NAD（P）H：quinone oxidoreductase 1 （NQOI） C609T polymorphism and colon cancer risk in farmers from western region of Inner Mongolia. Methods： Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was performed to analyze NQO1 C...
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| Veröffentlicht in: | 中国癌症研究：英文版 2012, Vol.24 (4), p.317-322 |
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| creator | Xiu-Lan Su Mei-Rong Yan Ling Yang Qimuge-Suyila |
| description | Objective： To investigate the relationship between NAD（P）H：quinone oxidoreductase 1 （NQOI） C609T polymorphism and colon cancer risk in farmers from western region of Inner Mongolia. Methods： Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was performed to analyze NQO1 C609T polymorphism from 160 healthy controls and 76 colon cancer patients. Results： Among the colon cancer patients, the incidence of NQOI T allele （53.29%） was significantly higher than it in control group （33.75%, P〈0.001）. The individuals with NQO1 T allele had higher risk [2.239 （95% CI： 1.510-3.321） times] to develop colon cancer than individuals with NQO1 C allele. The incidence of NQO1 （TFI-） （34.21%） in colon cancer patients was higher than that in control group （15.62%, P〈0.001）. Odds ratios （OR） analysis suggested that NQO1 （T/F） and NQOI （T/C） genotype carriers had 3.813 （95% CI： 1.836-7.920） times and 2.080 （1.026-4.219） times risk compared with wild-type NQO1 （C/C） gene carriers in developing colon cancer. Individuals with NQO1 （T/I＇） genotype had 2.541 （95% CI： 0.990-6.552） times, 3.713 （95% CI： 1.542-8.935） times, and 3.471 （95% CI： 1.356-8.886） times risk than individuals with NQOI （T/C） or NQOI （C/C） genotype in well- differentiated, moderately-differentiated, and poorly-differentiated colon cancer patients, respectively. Conclusions： NQO1 gene C609T could be one of risk factors of colon cancer in farmers from western region of Inner Mongolia, |
| format | Article |
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Methods： Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was performed to analyze NQO1 C609T polymorphism from 160 healthy controls and 76 colon cancer patients. Results： Among the colon cancer patients, the incidence of NQOI T allele （53.29%） was significantly higher than it in control group （33.75%, P〈0.001）. The individuals with NQO1 T allele had higher risk [2.239 （95% CI： 1.510-3.321） times] to develop colon cancer than individuals with NQO1 C allele. The incidence of NQO1 （TFI-） （34.21%） in colon cancer patients was higher than that in control group （15.62%, P〈0.001）. Odds ratios （OR） analysis suggested that NQO1 （T/F） and NQOI （T/C） genotype carriers had 3.813 （95% CI： 1.836-7.920） times and 2.080 （1.026-4.219） times risk compared with wild-type NQO1 （C/C） gene carriers in developing colon cancer. Individuals with NQO1 （T/I＇） genotype had 2.541 （95% CI： 0.990-6.552） times, 3.713 （95% CI： 1.542-8.935） times, and 3.471 （95% CI： 1.356-8.886） times risk than individuals with NQOI （T/C） or NQOI （C/C） genotype in well- differentiated, moderately-differentiated, and poorly-differentiated colon cancer patients, respectively. Conclusions： NQO1 gene C609T could be one of risk factors of colon cancer in farmers from western region of Inner Mongolia,</description><identifier>ISSN: 1000-9604</identifier><identifier>EISSN: 1993-0631</identifier><language>eng</language><subject>PCR-RFLP ; 内蒙古西部地区 ; 农民 ; 危险因素 ; 等位基因 ; 结肠癌 ; 聚合酶链反应 ; 限制性片段长度多态性</subject><ispartof>中国癌症研究：英文版, 2012, Vol.24 (4), p.317-322</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85190X/85190X.jpg</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids></links><search><creatorcontrib>Xiu-Lan Su Mei-Rong Yan Ling Yang Qimuge-Suyila</creatorcontrib><title>NQ01 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia</title><title>中国癌症研究：英文版</title><addtitle>Chinese Journal of Cancer Research</addtitle><description>Objective： To investigate the relationship between NAD（P）H：quinone oxidoreductase 1 （NQOI） C609T polymorphism and colon cancer risk in farmers from western region of Inner Mongolia. Methods： Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was performed to analyze NQO1 C609T polymorphism from 160 healthy controls and 76 colon cancer patients. Results： Among the colon cancer patients, the incidence of NQOI T allele （53.29%） was significantly higher than it in control group （33.75%, P〈0.001）. The individuals with NQO1 T allele had higher risk [2.239 （95% CI： 1.510-3.321） times] to develop colon cancer than individuals with NQO1 C allele. The incidence of NQO1 （TFI-） （34.21%） in colon cancer patients was higher than that in control group （15.62%, P〈0.001）. Odds ratios （OR） analysis suggested that NQO1 （T/F） and NQOI （T/C） genotype carriers had 3.813 （95% CI： 1.836-7.920） times and 2.080 （1.026-4.219） times risk compared with wild-type NQO1 （C/C） gene carriers in developing colon cancer. Individuals with NQO1 （T/I＇） genotype had 2.541 （95% CI： 0.990-6.552） times, 3.713 （95% CI： 1.542-8.935） times, and 3.471 （95% CI： 1.356-8.886） times risk than individuals with NQOI （T/C） or NQOI （C/C） genotype in well- differentiated, moderately-differentiated, and poorly-differentiated colon cancer patients, respectively. Conclusions： NQO1 gene C609T could be one of risk factors of colon cancer in farmers from western region of Inner Mongolia,</description><subject>PCR-RFLP</subject><subject>内蒙古西部地区</subject><subject>农民</subject><subject>危险因素</subject><subject>等位基因</subject><subject>结肠癌</subject><subject>聚合酶链反应</subject><subject>限制性片段长度多态性</subject><issn>1000-9604</issn><issn>1993-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNyk0KwjAQhuEgCv7eYTxAYWprNWtRdKEgdC-hpm00ydRJQby9WXgAV9_7wTMQk1TKLMEiS4exETGRBeZjMQ3hgbjerDGdiPZyxRR2BcoSOrIfR9y1JjioiFlb1es79BSfJQ-V8pVmYBOeYDzUip3mADWTg7cOvWYPrBsTKdVw8j7iM_mGrFFzMaqVDXrx25lYHvbl7phUbRQv45tbx8Yp_tzyHAvcrmT2j_kCiSFG4g</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Xiu-Lan Su Mei-Rong Yan Ling Yang Qimuge-Suyila</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope></search><sort><creationdate>2012</creationdate><title>NQ01 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia</title><author>Xiu-Lan Su Mei-Rong Yan Ling Yang Qimuge-Suyila</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-chongqing_primary_440608293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>PCR-RFLP</topic><topic>内蒙古西部地区</topic><topic>农民</topic><topic>危险因素</topic><topic>等位基因</topic><topic>结肠癌</topic><topic>聚合酶链反应</topic><topic>限制性片段长度多态性</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiu-Lan Su Mei-Rong Yan Ling Yang Qimuge-Suyila</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><jtitle>中国癌症研究：英文版</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiu-Lan Su Mei-Rong Yan Ling Yang Qimuge-Suyila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NQ01 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia</atitle><jtitle>中国癌症研究：英文版</jtitle><addtitle>Chinese Journal of Cancer Research</addtitle><date>2012</date><risdate>2012</risdate><volume>24</volume><issue>4</issue><spage>317</spage><epage>322</epage><pages>317-322</pages><issn>1000-9604</issn><eissn>1993-0631</eissn><abstract>Objective： To investigate the relationship between NAD（P）H：quinone oxidoreductase 1 （NQOI） C609T polymorphism and colon cancer risk in farmers from western region of Inner Mongolia. Methods： Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was performed to analyze NQO1 C609T polymorphism from 160 healthy controls and 76 colon cancer patients. Results： Among the colon cancer patients, the incidence of NQOI T allele （53.29%） was significantly higher than it in control group （33.75%, P〈0.001）. The individuals with NQO1 T allele had higher risk [2.239 （95% CI： 1.510-3.321） times] to develop colon cancer than individuals with NQO1 C allele. The incidence of NQO1 （TFI-） （34.21%） in colon cancer patients was higher than that in control group （15.62%, P〈0.001）. Odds ratios （OR） analysis suggested that NQO1 （T/F） and NQOI （T/C） genotype carriers had 3.813 （95% CI： 1.836-7.920） times and 2.080 （1.026-4.219） times risk compared with wild-type NQO1 （C/C） gene carriers in developing colon cancer. Individuals with NQO1 （T/I＇） genotype had 2.541 （95% CI： 0.990-6.552） times, 3.713 （95% CI： 1.542-8.935） times, and 3.471 （95% CI： 1.356-8.886） times risk than individuals with NQOI （T/C） or NQOI （C/C） genotype in well- differentiated, moderately-differentiated, and poorly-differentiated colon cancer patients, respectively. Conclusions： NQO1 gene C609T could be one of risk factors of colon cancer in farmers from western region of Inner Mongolia,</abstract></addata></record> |
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| identifier | ISSN: 1000-9604 |
| ispartof | 中国癌症研究：英文版, 2012, Vol.24 (4), p.317-322 |
| issn | 1000-9604 1993-0631 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | PCR-RFLP 内蒙古西部地区 农民 危险因素 等位基因 结肠癌 聚合酶链反应 限制性片段长度多态性 |
| title | NQ01 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia |
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