Repressing malic enzyme 1 unbalances the redox state, redirects glucose metabolism, and attenuates migratory and invasive abilities in nasopharyngeal carcinoma cell lines
A large amount of nicotinamide adenine dinucleotide phosphate (NADPH) is required for fatty acid synthesis and maintenance of the redox state in cancer cells. Malic enzyme 1 (ME1)-dependent NADPH production is one of the three pathways that contribute to the formation of the cytosolic NADPH pool. ME...
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Veröffentlicht in: | 癌症:英文版 2012, Vol.31 (11), p.519-531 |
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