Autoimmune thyroid diseases and Helicobacterpylori： The correlation is present only in Graves＇s disease
AIM： To investigate the correlation between autoimmune thyroid diseases （ATDs） and the prevalence of Cag-A positive strains of Helicobacter pylori （H. pylori） in stool samples. METHODS： We investigated 112 consecutive Caucasian patients （48 females and 4 males with Graves＇ disease and 54 females and...
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| Veröffentlicht in: | 世界胃肠病学杂志：英文版 2012, Vol.18 (10), p.1093-1097 |
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| container_title | 世界胃肠病学杂志：英文版 |
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| creator | Vincenzo Bassi Gennaro Marino Alba Iengo Olimpia Fattoruso Crescenzo Santinelli |
| description | AIM： To investigate the correlation between autoimmune thyroid diseases （ATDs） and the prevalence of Cag-A positive strains of Helicobacter pylori （H. pylori） in stool samples. METHODS： We investigated 112 consecutive Caucasian patients （48 females and 4 males with Graves＇ disease and 54 females and 6 males with Hashimoto＇ s thyroiditis HT）, at their first diagnosis of ATDs. We tested for H. pylori in stool samples using an amplified enzyme immunoassay and Cag-A in serum samples using an enzyme-linked immunoassay method （ELISA）. The results were analyzed using the two-sided Fisher＇ s exact test and the respective odds ratio （OR） was calculated. RESULTS： A marked correlation was found between the presence of H. pylori （P ≤ 0.0001, OR 6.3） and, in particular, Cag-A positive strains （P ≤ 0.005, OR 5.3）in Graves＇ disease, but not in Hashimoto＇s thyroiditis, where we found only a correlation with Cag-A strains （P ≤ 0.005, OR 8.73） but not when H. pylori was present. CONCLUSION： The marked correlation between H. pylori and Cag-A, found in ATDs, could be dependent on the different expression of adhesion molecules in the gastric mucosa. |
| format | Article |
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METHODS： We investigated 112 consecutive Caucasian patients （48 females and 4 males with Graves＇ disease and 54 females and 6 males with Hashimoto＇ s thyroiditis HT）, at their first diagnosis of ATDs. We tested for H. pylori in stool samples using an amplified enzyme immunoassay and Cag-A in serum samples using an enzyme-linked immunoassay method （ELISA）. The results were analyzed using the two-sided Fisher＇ s exact test and the respective odds ratio （OR） was calculated. RESULTS： A marked correlation was found between the presence of H. pylori （P ≤ 0.0001, OR 6.3） and, in particular, Cag-A positive strains （P ≤ 0.005, OR 5.3）in Graves＇ disease, but not in Hashimoto＇s thyroiditis, where we found only a correlation with Cag-A strains （P ≤ 0.005, OR 8.73） but not when H. pylori was present. CONCLUSION： The marked correlation between H. pylori and Cag-A, found in ATDs, could be dependent on the different expression of adhesion molecules in the gastric mucosa.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><language>eng</language><subject>ELISA ; Fisher ; 幽门螺旋杆菌 ; 幽门螺杆菌 ; 甲状腺疾病 ; 精确测试 ; 自身免疫性 ; 酶联免疫法</subject><ispartof>世界胃肠病学杂志：英文版, 2012, Vol.18 (10), p.1093-1097</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><link.rule.ids>314,780,784,4022</link.rule.ids></links><search><creatorcontrib>Vincenzo Bassi Gennaro Marino Alba Iengo Olimpia Fattoruso Crescenzo Santinelli</creatorcontrib><title>Autoimmune thyroid diseases and Helicobacterpylori： The correlation is present only in Graves＇s disease</title><title>世界胃肠病学杂志：英文版</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM： To investigate the correlation between autoimmune thyroid diseases （ATDs） and the prevalence of Cag-A positive strains of Helicobacter pylori （H. pylori） in stool samples. 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METHODS： We investigated 112 consecutive Caucasian patients （48 females and 4 males with Graves＇ disease and 54 females and 6 males with Hashimoto＇ s thyroiditis HT）, at their first diagnosis of ATDs. We tested for H. pylori in stool samples using an amplified enzyme immunoassay and Cag-A in serum samples using an enzyme-linked immunoassay method （ELISA）. The results were analyzed using the two-sided Fisher＇ s exact test and the respective odds ratio （OR） was calculated. RESULTS： A marked correlation was found between the presence of H. pylori （P ≤ 0.0001, OR 6.3） and, in particular, Cag-A positive strains （P ≤ 0.005, OR 5.3）in Graves＇ disease, but not in Hashimoto＇s thyroiditis, where we found only a correlation with Cag-A strains （P ≤ 0.005, OR 8.73） but not when H. pylori was present. CONCLUSION： The marked correlation between H. pylori and Cag-A, found in ATDs, could be dependent on the different expression of adhesion molecules in the gastric mucosa.</abstract></addata></record> |
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| identifier | ISSN: 1007-9327 |
| ispartof | 世界胃肠病学杂志：英文版, 2012, Vol.18 (10), p.1093-1097 |
| issn | 1007-9327 2219-2840 |
| language | eng |
| recordid | cdi_chongqing_primary_41630196 |
| source | Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | ELISA Fisher 幽门螺旋杆菌 幽门螺杆菌 甲状腺疾病 精确测试 自身免疫性 酶联免疫法 |
| title | Autoimmune thyroid diseases and Helicobacterpylori： The correlation is present only in Graves＇s disease |
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