Laboratory animals as surrogate models of human ）besity

Laboratory animals as surrogate models of human ）besity

Obesity and obesity-related metabolic diseases represent a growing socioeconomic problem throughout the world. Great emphasis has been put on establishing treatments for this condition, including pharmacological intervention. However, there are many obsta- cles and pitfalls in the development proces...

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Veröffentlicht in:中国药理学报：英文版 2012, Vol.33 (2), p.173-181
1. Verfasser: Cecilia NILSSONt Kirsten RAUN Fei-fei YAN Marianne O LARSEN Mads TANG-CHRISTENSEN
Format: Artikel
Sprache:eng
Schlagworte:
临床观察
人类
代谢性疾病
多基因遗传
实验动物
模型
社会经济问题
转化模式
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container_end_page 181
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container_title 中国药理学报：英文版
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creator Cecilia NILSSONt Kirsten RAUN Fei-fei YAN Marianne O LARSEN Mads TANG-CHRISTENSEN
description Obesity and obesity-related metabolic diseases represent a growing socioeconomic problem throughout the world. Great emphasis has been put on establishing treatments for this condition, including pharmacological intervention. However, there are many obsta- cles and pitfalls in the development process from pre-clinical research to the pharmacy counter, and there is no certainty that what has been observed pre-clinically will translate into an improvement in human health. Hence, it is important to test potential new drugs in a valid translational model early in their development. In the current mini-review, a number of monogenetic and polygenic models of obesity will be discussed in view of their translational character.
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source PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry
subjects 临床观察
人类
代谢性疾病
多基因遗传
实验动物
模型
社会经济问题
转化模式
title Laboratory animals as surrogate models of human ）besity
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