CONSTRUCTION OF A BIVALENT ORAL VACCINE FOR PREVENTION OF TYPHOID FEVER AND CHOLERA DIARRHEA

CONSTRUCTION OF A BIVALENT ORAL VACCINE FOR PREVENTION OF TYPHOID FEVER AND CHOLERA DIARRHEA

A recombinant plasmid pMM-CTB containing the gene for production of the nontoxic B subunit of Vibrio cholera was transferred into a safe, effective and attenuated oral vaccine Ty21a strain of Salmonella typhi. The resulting Ty21a(pMM-CTB) could steadily produce CT-B subunit that was secreted extrace...

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Veröffentlicht in:中国科学：化学英文版 1990 (1), p.44-49
1. Verfasser: 马清钧 于秀琴 刘传暄 周建光 熊凌霜 黄翠芬
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cholera
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typhi
vaccine
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creator 马清钧 于秀琴 刘传暄 周建光 熊凌霜 黄翠芬
description A recombinant plasmid pMM-CTB containing the gene for production of the nontoxic B subunit of Vibrio cholera was transferred into a safe, effective and attenuated oral vaccine Ty21a strain of Salmonella typhi. The resulting Ty21a(pMM-CTB) could steadily produce CT-B subunit that was secreted extracellularly and had the same antigenicity as CT-B produced by V. cholera. Furthermore, the characteristics of the antigenicity, the persistance in mice and the galactose sensitivity possessed in the strain of Ty21a were also retained in Ty21a (pMM-CTB). A bivalent vaccine containing Ty21a (pMM-CTB) and the killed whole cell of V. cholera was then constructed which had good immunogenecity for typhoid fever and cholera diarrhea.
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subjects cholera
oral
typhi
vaccine
title CONSTRUCTION OF A BIVALENT ORAL VACCINE FOR PREVENTION OF TYPHOID FEVER AND CHOLERA DIARRHEA
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