The Effects of Human Fetal Liver Cells on Experimental Fulminant Hepatic Failure in Rats
The beneficial dffects of human fetal liver cells on the D-galactosamine-inducedfulminant hepatic failure were observed in rats and the mechanisms of the effects investi-gated.The survival rate of the rats intraperitoneally injected with liver cell suspensionand cytosol was 47.37% and 42.11% respect...
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| Veröffentlicht in: | 中国人民解放军军医大学学报：英文版 1990 (3), p.246-250 |
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| container_title | 中国人民解放军军医大学学报：英文版 |
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| creator | 郝飞 向居正 李奇芬 余曼英 |
| description | The beneficial dffects of human fetal liver cells on the D-galactosamine-inducedfulminant hepatic failure were observed in rats and the mechanisms of the effects investi-gated.The survival rate of the rats intraperitoneally injected with liver cell suspensionand cytosol was 47.37% and 42.11% respectively which was significantly higher than5.26% of the controls（P<0.05）.There was no statistical significance between the differ-ence of the survival rates due to two preparations.The administration of cytosol two hours before the intoduction of D-galactosamine re-sulted in a significant lowering of the plasma level of endotoxin and hepaticmalondialdehyde in rats and a marked increase of 3H-thymindinc incorporation intohepatic DNA(DPM/OD260)as compared with the parameters of the controls.These re-sults suggest that there might be some biological active substance in human fetal liver cellswhich is responsible for thc effects to increase the survival rate. |
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D-galactosamine-inducedfulminant hepatic failure were observed in rats and the mechanisms of the effects investi-gated.The survival rate of the rats intraperitoneally injected with liver cell suspensionand cytosol was 47.37% and 42.11% respectively which was significantly higher than5.26% of the controls（P&lt;0.05）.There was no statistical significance between the differ-ence of the survival rates due to two preparations.The administration of cytosol two hours before the intoduction of D-galactosamine re-sulted in a significant lowering of the plasma level of endotoxin and hepaticmalondialdehyde in rats and a marked increase of 3H-thymindinc incorporation intohepatic DNA(DPM/OD260)as compared with the parameters of the controls.These re-sults suggest that there might be some biological active substance in human fetal liver cellswhich is responsible for thc effects to increase the survival rate.</description><identifier>ISSN: 2095-7467</identifier><language>eng</language><subject>3H-thymidine ; cytosol ; diseases ; endotoxin ; failure ; galactosamine ; hepatic ; liver ; malondialdehyde</subject><ispartof>中国人民解放军军医大学学报：英文版, 1990 (3), p.246-250</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84233X/84233X.jpg</thumbnail><link.rule.ids>314,780,784,4022</link.rule.ids></links><search><creatorcontrib>郝飞 向居正 李奇芬 余曼英</creatorcontrib><title>The Effects of Human Fetal Liver Cells on Experimental Fulminant Hepatic Failure in Rats</title><title>中国人民解放军军医大学学报：英文版</title><addtitle>Journal of Medical Colleges of PLA(China)</addtitle><description>The beneficial dffects of human fetal liver cells on the D-galactosamine-inducedfulminant hepatic failure were observed in rats and the mechanisms of the effects investi-gated.The survival rate of the rats intraperitoneally injected with liver cell suspensionand cytosol was 47.37% and 42.11% respectively which was significantly higher than5.26% of the controls（P&lt;0.05）.There was no statistical significance between the differ-ence of the survival rates due to two preparations.The administration of cytosol two hours before the intoduction of D-galactosamine re-sulted in a significant lowering of the plasma level of endotoxin and hepaticmalondialdehyde in rats and a marked increase of 3H-thymindinc incorporation intohepatic DNA(DPM/OD260)as compared with the parameters of the controls.These re-sults suggest that there might be some biological active substance in human fetal liver cellswhich is responsible for thc effects to increase the survival rate.</description><subject>3H-thymidine</subject><subject>cytosol</subject><subject>diseases</subject><subject>endotoxin</subject><subject>failure</subject><subject>galactosamine</subject><subject>hepatic</subject><subject>liver</subject><subject>malondialdehyde</subject><issn>2095-7467</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNqNjL0KgzAYADO0UGl9hw86C_5EJbMYHDoVh26SyhcNxGiTWNq3r4U-QKcb7rgdCdKY5VFJi_JAQufUPaa0zLOEsYDc2hGhlhJ772CW0KyTMMDRCw0X9UQLFWq9KQP1a0GrJjRfx1c9KSOMhwYX4VUPXCi9WgRl4Cq8O5G9FNph-OORnHndVk3Uj7MZHsoM3bLdhH13NI6TImU0Y9l_1QccD0C5</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>郝飞 向居正 李奇芬 余曼英</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope></search><sort><creationdate>1990</creationdate><title>The Effects of Human Fetal Liver Cells on Experimental Fulminant Hepatic Failure in Rats</title><author>郝飞 向居正 李奇芬 余曼英</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-chongqing_primary_40016294393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>3H-thymidine</topic><topic>cytosol</topic><topic>diseases</topic><topic>endotoxin</topic><topic>failure</topic><topic>galactosamine</topic><topic>hepatic</topic><topic>liver</topic><topic>malondialdehyde</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>郝飞 向居正 李奇芬 余曼英</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><jtitle>中国人民解放军军医大学学报：英文版</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>郝飞 向居正 李奇芬 余曼英</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Human Fetal Liver Cells on Experimental Fulminant Hepatic Failure in Rats</atitle><jtitle>中国人民解放军军医大学学报：英文版</jtitle><addtitle>Journal of Medical Colleges of PLA(China)</addtitle><date>1990</date><risdate>1990</risdate><issue>3</issue><spage>246</spage><epage>250</epage><pages>246-250</pages><issn>2095-7467</issn><abstract>The beneficial dffects of human fetal liver cells on the D-galactosamine-inducedfulminant hepatic failure were observed in rats and the mechanisms of the effects investi-gated.The survival rate of the rats intraperitoneally injected with liver cell suspensionand cytosol was 47.37% and 42.11% respectively which was significantly higher than5.26% of the controls（P&lt;0.05）.There was no statistical significance between the differ-ence of the survival rates due to two preparations.The administration of cytosol two hours before the intoduction of D-galactosamine re-sulted in a significant lowering of the plasma level of endotoxin and hepaticmalondialdehyde in rats and a marked increase of 3H-thymindinc incorporation intohepatic DNA(DPM/OD260)as compared with the parameters of the controls.These re-sults suggest that there might be some biological active substance in human fetal liver cellswhich is responsible for thc effects to increase the survival rate.</abstract></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2095-7467 |
| ispartof | 中国人民解放军军医大学学报：英文版, 1990 (3), p.246-250 |
| issn | 2095-7467 |
| language | eng |
| recordid | cdi_chongqing_primary_4001629439 |
| source | Alma/SFX Local Collection |
| subjects | 3H-thymidine cytosol diseases endotoxin failure galactosamine hepatic liver malondialdehyde |
| title | The Effects of Human Fetal Liver Cells on Experimental Fulminant Hepatic Failure in Rats |
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