Immunohistochemical Studies on Anti-keratin Autoantibody

On the basis of the detection of IgG anti-keratin autoantibody (AK auto Ab)in human body fluids,it was shown that IgG AK auto Ab could hardly pass the blood-brain barrier,but it could easily penetrate the capillary walls into epithelial tissues.Un-der electron microscope,the interaction between AK a...

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Veröffentlicht in:中国人民解放军军医大学学报:英文版 1990 (2), p.165-167
1. Verfasser: 刘玉峰 刘彦仿 丁华野 车乃增 张泰山 丁丽清 樊平申
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container_title 中国人民解放军军医大学学报:英文版
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creator 刘玉峰 刘彦仿 丁华野 车乃增 张泰山 丁丽清 樊平申
description On the basis of the detection of IgG anti-keratin autoantibody (AK auto Ab)in human body fluids,it was shown that IgG AK auto Ab could hardly pass the blood-brain barrier,but it could easily penetrate the capillary walls into epithelial tissues.Un-der electron microscope,the interaction between AK auto Ab and keratinocyte is largelylocated in tonofilaments and desmosomes and is irrelevant to other organellae.Dynamicobservations of AK auto Ab suggest that the accumulation of AK auto Ab in keratinocy-te cytoplasm and transitory decrease of IgG AK auto Ab in serum of rabbits with sodiumsulfide dermatitis are related predominantly to keratinocytic injury.
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identifier ISSN: 2095-7467
ispartof 中国人民解放军军医大学学报:英文版, 1990 (2), p.165-167
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source Alma/SFX Local Collection
subjects autoantibody
keratin
title Immunohistochemical Studies on Anti-keratin Autoantibody
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