Possibility of Targeting Treatment for Ischemic Heart Disease With Liposome (Ⅱ)

Possibility of Targeting Treatment for Ischemic Heart Disease With Liposome (Ⅱ)

Studies on the isolated rat heart perfusion model have proved that perfusion with high Ca2+ （4.5 mmol/L）, high K+ （8.7 mmol/L） or tree radical generating system （FRGS） significantly increases myocardial uptake of liposomes. Intravenous injection of liposomes covalently combined with antibody of rat...

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Veröffentlicht in:中国科学：数学英文版 1993 (7), p.809-816
1. Verfasser: 唐朝枢 苏静怡 李兆萍 张灵芝 杨军 齐鸣 刘福安 汤健
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Sprache:eng
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heart
injury
ischemia
ischemia-reperfusion
liposome
myocardial
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container_title 中国科学：数学英文版
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creator 唐朝枢 苏静怡 李兆萍 张灵芝 杨军 齐鸣 刘福安 汤健
description Studies on the isolated rat heart perfusion model have proved that perfusion with high Ca2+ （4.5 mmol/L）, high K+ （8.7 mmol/L） or tree radical generating system （FRGS） significantly increases myocardial uptake of liposomes. Intravenous injection of liposomes covalently combined with antibody of rat myocardial cells obviously elevates the target action of liposomes to myocardium. Liposome-carried SOD for treatment of rat myocardial ischemia-reperfusion injury is much more effective than simple SOD. The results evidence that the liposome as drug carrier for treatment of ischemic heart diseases shows a broad prospect for its clinical use.
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ispartof 中国科学：数学英文版, 1993 (7), p.809-816
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1869-1862
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source Alma/SFX Local Collection
subjects heart
injury
ischemia
ischemia-reperfusion
liposome
myocardial
title Possibility of Targeting Treatment for Ischemic Heart Disease With Liposome (Ⅱ)
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