Design, synthesis and bioactivity of novel ALS enzyme inhibitors (II)——Molecular mechanics, quantum chemistry and structure-activity relationship studies on the herbicidal heterocyclic sulfonamide
In view of quantum pharmacology, the structure-activity relationships of different kinds of fused heterocydic sulfonamides with the same mode of action were first investigated using molecular mechanics, quantum chemistry and discriminatory analysis. It has been found that the process of the interact...
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| Veröffentlicht in: | 中国科学：化学英文版 1996 (1), p.78-85 |
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| container_title | 中国科学：化学英文版 |
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| creator | 陆荣健 杨华铮 尚贞锋 汪惟为 潘荫明 赵学庄 |
| description | In view of quantum pharmacology, the structure-activity relationships of different kinds of fused heterocydic sulfonamides with the same mode of action were first investigated using molecular mechanics, quantum chemistry and discriminatory analysis. It has been found that the process of the interaction of the fused heterocydic sulfonamide with ALS enzyme involves the electropositive region of the sulfonyl bridge chain and the electronegative region of the heterocydic moiety. The herbicidal activity is related to the potency of electric charge translocation of the related regions. |
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It has been found that the process of the interaction of the fused heterocydic sulfonamide with ALS enzyme involves the electropositive region of the sulfonyl bridge chain and the electronegative region of the heterocydic moiety. The herbicidal activity is related to the potency of electric charge translocation of the related regions.</description><identifier>ISSN: 1674-7291</identifier><identifier>EISSN: 1869-1870</identifier><language>eng</language><subject>ALS ; enzyme ; fused ; heterocyclic ; inhibitor ; pharmacology ; quantum ; relationship ; structure-activity ; sulfonamide ; sulfonylurea</subject><ispartof>中国科学：化学英文版, 1996 (1), p.78-85</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/60113X/60113X.jpg</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids></links><search><creatorcontrib>陆荣健 杨华铮 尚贞锋 汪惟为 潘荫明 赵学庄</creatorcontrib><title>Design, synthesis and bioactivity of novel ALS enzyme inhibitors (II)——Molecular mechanics, quantum chemistry and structure-activity relationship studies on the herbicidal heterocyclic sulfonamide</title><title>中国科学：化学英文版</title><addtitle>SCIENCE CHINA Chemistry</addtitle><description>In view of quantum pharmacology, the structure-activity relationships of different kinds of fused heterocydic sulfonamides with the same mode of action were first investigated using molecular mechanics, quantum chemistry and discriminatory analysis. 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| fulltext | fulltext |
| identifier | ISSN: 1674-7291 |
| ispartof | 中国科学：化学英文版, 1996 (1), p.78-85 |
| issn | 1674-7291 1869-1870 |
| language | eng |
| recordid | cdi_chongqing_primary_4001140077 |
| source | Alma/SFX Local Collection |
| subjects | ALS enzyme fused heterocyclic inhibitor pharmacology quantum relationship structure-activity sulfonamide sulfonylurea |
| title | Design, synthesis and bioactivity of novel ALS enzyme inhibitors (II)——Molecular mechanics, quantum chemistry and structure-activity relationship studies on the herbicidal heterocyclic sulfonamide |
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