Platinum-(IV)-derivative satraplatin induced G2/M cell cycle perturbation via p53-p21Waf1/xlp1-independent pathway in human colorectal cancer cells

Aim: Platinum-(IV)-derivative satraplatin represents a new generation of orally available anti-cancer drugs that are under development for the treatment of several cancers. Understanding the mechanisms of cell cycle modulation and apoptosis is necessary to define the mode of action of satraplatin. I...

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Veröffentlicht in:中国药理学报:英文版 2011, Vol.32 (11), p.1387-1396
1. Verfasser: Murugan KALIMUTHO Antonella MINUTOLO Sandro GRELLI Giorgio FEDERICI Sergio BERNARDINI
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Sprache:eng
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