5-hydroxytryptamlne-mediated apnea caused by the habenular nucleus

5-hydroxytryptamlne-mediated apnea caused by the habenular nucleus

5-hydroxytryptamine contributes to the control of activities of the dilator muscle in the upper respiratory tract, and is derived from the raphe nuclei, in which the habenular nucleus exerts a sustaJned inhibitory effect. In the present study, respiratory motion curve of the genJoglossus muscle and...

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Veröffentlicht in:中国神经再生研究：英文版 2011, Vol.6 (20), p.1554-1558
1. Verfasser: Min Wang Weihong Lin Jinghua Wang Min Huang Chunyong Wang Mingxian Li Shao Wang
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Sprache:eng
Schlagworte:
Wistar大鼠
上呼吸道
介导
睡眠呼吸暂停
综合征
缰核
羟色胺
肌电活动
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creator Min Wang Weihong Lin Jinghua Wang Min Huang Chunyong Wang Mingxian Li Shao Wang
description 5-hydroxytryptamine contributes to the control of activities of the dilator muscle in the upper respiratory tract, and is derived from the raphe nuclei, in which the habenular nucleus exerts a sustaJned inhibitory effect. In the present study, respiratory motion curve of the genJoglossus muscle and peripheral 5-hydroxytryptamine changes were observed following L-glutamate stimulation of the habenular nucleus of adult Wistar rats. Results showed that the rats had apnea and decreased plasma 5-hydroxytryptamine content after the neurons in habenular nucleus were excited. Genioglossus muscle electromyogram amplitude and integral were significantly reduced. The genioglossus myoelectric activity and respiratory motion curve were similar to obstructive sleep apnea syndrome, thus confirming that the habenular nucleus is the key nucleus involved in the pathogenesis of obstructive sleep apnea syndrome, and is the primary regulated center in the raphe nuclei. Stimulation of the habenular nucleus may suppress 5-hydroxytryptamine release and result in apnea, which is similar to obstructive sleep apnea syndrome.
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subjects Wistar大鼠
上呼吸道
介导
睡眠呼吸暂停
综合征
缰核
羟色胺
肌电活动
title 5-hydroxytryptamlne-mediated apnea caused by the habenular nucleus
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