Synthesis and antitumor evaluation of fluoroquinolone C3 fused heterocycles （II）： From triazolothiadiazines to pyrazolotriazoles

Synthesis and antitumor evaluation of fluoroquinolone C3 fused heterocycles （II）： From triazolothiadiazines to pyrazolotriazoles

To further expand an effective modified route for the shift from an antibacterial fluoroquinolone （FQ） to an antitumor FQ, two series of title compounds based on an isostere of the FQ C3 carboxylic group with two fused heterocyclic rings, [ 1,2,4]triazolo[3,4- b][1,3,4]thiadiazine and pyrazolo[5,1-c...

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Veröffentlicht in:中国化学快报：英文版 2011, Vol.22 (7), p.804-806
1. Verfasser: Guo Qiang Hu Li Li Hou Yong Yang Lei Yi Song Qiang Xie Guo Qiang Wang Nan Nan Duan Tie Yao Chao Xiao Yi Wen Wen Long Huang
Format: Artikel
Sprache:eng
Schlagworte:
IC50
三唑并
体外抗肿瘤活性
化合物
合成
杂环
氟喹诺酮类药物
评价
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description To further expand an effective modified route for the shift from an antibacterial fluoroquinolone （FQ） to an antitumor FQ, two series of title compounds based on an isostere of the FQ C3 carboxylic group with two fused heterocyclic rings, [ 1,2,4]triazolo[3,4- b][1,3,4]thiadiazine and pyrazolo[5,1-c][1,2,4]triazole, respectively, were designed and synthesized starting from the current antibacterial FQs, and their in vitro antitumor activity against L1210, CHO cell lines were evaluated via their respective IC50 values.
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source Access via ScienceDirect (Elsevier); Alma/SFX Local Collection
subjects IC50
三唑并
体外抗肿瘤活性
化合物
合成
杂环
氟喹诺酮类药物
评价
title Synthesis and antitumor evaluation of fluoroquinolone C3 fused heterocycles （II）： From triazolothiadiazines to pyrazolotriazoles
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