Ototoxicity induced by kanamycin in iron-deficient young rats
Using auditory electrophysiological,histopathological,enzymehistochemical and scanning electron microscopic techniques,we observed thechanges of function and structure of cochlea in iron-deficient growing rats receiv-ing kanamycin intramuscularly.The results showed that at an equal dose ofkanamycin,...
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| Veröffentlicht in: | 中国人民解放军军医大学学报：英文版 1991 (1), p.78-83 |
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| container_title | 中国人民解放军军医大学学报：英文版 |
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| creator | 迟放鲁 萧轼之 李兆基 江德胜 孙爱华 |
| description | Using auditory electrophysiological,histopathological,enzymehistochemical and scanning electron microscopic techniques,we observed thechanges of function and structure of cochlea in iron-deficient growing rats receiv-ing kanamycin intramuscularly.The results showed that at an equal dose ofkanamycin,hearing loss and hair cell damage were more serious,and incidence ofhearing loss was much higher in iron-deficient rats than in normal rats.Theinhibition of succinate dehydrogenase activity of cochlea induced by interaction ofkanamycin and iron deficiency was more obvious than that by either one of them.Iron deficiency can increase the sensitivity of cochlea to kanamycin.The resultsindicated that iron deficiency may be one of the reasons for high incidence ofototoxic deafness in children,and it should be cautious when using such drugs inchildren with iron-deficient anemia. |
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| ispartof | 中国人民解放军军医大学学报：英文版, 1991 (1), p.78-83 |
| issn | 2095-7467 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | cochlea deficiency hearing iron kanamycin loss ototoxicity |
| title | Ototoxicity induced by kanamycin in iron-deficient young rats |
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