HIGH EFFICIENT TRANSFER AND EXPRESSION OF HUMAN CLOTTING FACTOR Ⅸ cDNA IN CULTURED HUMAN PRIMARY SKIN FIBROBLASTS FROM HEMOPHILIA B PATIENT BY RETROVIRAL VECTORS

To study the possibility of somatic gene therapy for hemophilia B via gene transfer to primary factor Ⅸ-deficient skin fibroblasts, we constructed four retroviral vectors containing factor Ⅸ cDNA driven by retroviral LTR promoter, SV40 early promoter and mouse MT-I promoter, respectively. These retr...

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Veröffentlicht in:	中国科学：化学英文版 1992 (2), p.183-193
1. Verfasser:	戴一凡 邱信芳 薛京伦 刘祖洞
Format:	Artikel
Sprache:	eng
Schlagworte:	clotting factor gene retroviral therapy vector
Online-Zugang:	Volltext
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