Evolutionary implications of Avian Infectious Bronchitis Virus （AIBV） analysis

Evolutionary implications of Avian Infectious Bronchitis Virus （AIBV） analysis

For developing efficient vaccines, it is essential to identify which amino acid changes are most important to the survival of the virus. We investigate the amino acid substitution features in the Avian Infectious Bronchitis Virus （AIBV） antigenic domain of a vaccine serotype （DE072） and a virulent v...

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Veröffentlicht in:Cell research 2006, Vol.16 (3), p.323-327
1. Verfasser: Peng Shi LI YU Yun-xin Fu Jing-Fei Huang Ke-Qin Zhang Ya-ping Zhang
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传染病
冠状病毒
支气管病毒
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description For developing efficient vaccines, it is essential to identify which amino acid changes are most important to the survival of the virus. We investigate the amino acid substitution features in the Avian Infectious Bronchitis Virus （AIBV） antigenic domain of a vaccine serotype （DE072） and a virulent viral strain （GA98） to better understand adaptive evolution of AIBV. In addition, the SARS Coronavirus （SARS-CoV） was also analyzed in the same way. It is interesting to find that extreme comparability exists between AIBV and SARS in amino acid substitution pattern. It suggests that amino acid changes that result in overall shift of residue charge and polarity should be paid special attention to during the development of vaccines.
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subjects 传染病
冠状病毒
支气管病毒
title Evolutionary implications of Avian Infectious Bronchitis Virus （AIBV） analysis
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