中枢注射孤啡肽通过孤儿受体可抑制去卵巢大鼠正中隆起GnRH释放(英文)
目的本文旨在研究孤啡肽(Orphanin FQ,OFQ)对下丘脑促性腺激素释放激素(gonadotropin-releasing hormone,GnRH)释放的调节机制。方法应用推挽灌流和放射性免疫测定方法观察侧脑室注射OFQ和/或孤儿受体(opioidreceptor-like1receptor,ORL1receptor)特异性拮抗剂NC13对清醒去卵巢(ovariectomized,OVX)大鼠下丘脑正中隆起(median eminence,ME)GnRH释放的影响。结果侧脑室给予20和200nmol孤啡肽,注射后40到80min可明显抑制OVX大鼠ME的GnRH释放(P...
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| creator | 安晓飞 贺明 冯异 冯昊 余江毅 |
| description | 目的本文旨在研究孤啡肽(Orphanin FQ,OFQ)对下丘脑促性腺激素释放激素(gonadotropin-releasing hormone,GnRH)释放的调节机制。方法应用推挽灌流和放射性免疫测定方法观察侧脑室注射OFQ和/或孤儿受体(opioidreceptor-like1receptor,ORL1receptor)特异性拮抗剂NC13对清醒去卵巢(ovariectomized,OVX)大鼠下丘脑正中隆起(median eminence,ME)GnRH释放的影响。结果侧脑室给予20和200nmol孤啡肽,注射后40到80min可明显抑制OVX大鼠ME的GnRH释放(P |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | 促性腺激素释放激素 孤啡肽 正中隆起 黄体生成素 |
| title | 中枢注射孤啡肽通过孤儿受体可抑制去卵巢大鼠正中隆起GnRH释放(英文) |
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