Silymarin: a potent hepatoprotective agent in poultry industry
Silymarin is composed of flavonolignans and derived from the dry seed of milk thistle (Silybummarianum) herb. It is used as a hepatoprotective treatment for different liver ailments, mainly cirrhosis, jaundice, growth promotant, alcoholic liver disease, chronic hepatitis C, chronic liver diseases an...
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| Veröffentlicht in: | World's Poultry Science Journal 2017-09, Vol.73 (3), p.483-492 |
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| creator | SAEED, M. BABAZADEH, D. ARIF, M. ARAIN, M.A. BHUTTO, Z.A. SHAR, A.H. KAKAR, M.U. MANZOOR, R. CHAO, S. |
| description | Silymarin is composed of flavonolignans and derived from the dry seed of milk thistle (Silybummarianum) herb. It is used as a hepatoprotective treatment for different liver ailments, mainly cirrhosis, jaundice, growth promotant, alcoholic liver disease, chronic hepatitis C, chronic liver diseases and hepatocellular carcinoma. Reported medicinal properties are anti-inflammatory, immunomodulating, anti-diabetic, antioxidant, low toxicity, promising pharmacokinetics, protective, preventive, regenerative and antifibrotic effects and has been shown to be extremely safe. The mode of action by which silymarin might protect liver cells includes stabilisation of membranes, free radical scavenging, stimulation of hepatocyte protein synthesis and modulation of the immune response. In addition, silymarin can be used to treat jaundice disorders by ameliorating the levels of various hepatic enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Moreover, silymarin is able to moderate the immune system, by boosting IL-4, IFN-γ, and IL-10. The hepatoprotective effect of silymarin in poultry farming is poorly understood, although it may be used as a cheap, non-toxic and safe feed additive to manage liver related disorders and to replace synthetic drugs in poultry diets. Hence, this review will allow scientists, veterinarians, researchers, poultry producers to gain a pragmatic edge as well as perspective usage of Silymarin. A main priority is in finding the effective level in poultry whereby it acts as a natural liver tonic in the poultry industry and could reduce veterinary expenses. |
| doi_str_mv | 10.1017/S0043933917000538 |
| format | Article |
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It is used as a hepatoprotective treatment for different liver ailments, mainly cirrhosis, jaundice, growth promotant, alcoholic liver disease, chronic hepatitis C, chronic liver diseases and hepatocellular carcinoma. Reported medicinal properties are anti-inflammatory, immunomodulating, anti-diabetic, antioxidant, low toxicity, promising pharmacokinetics, protective, preventive, regenerative and antifibrotic effects and has been shown to be extremely safe. The mode of action by which silymarin might protect liver cells includes stabilisation of membranes, free radical scavenging, stimulation of hepatocyte protein synthesis and modulation of the immune response. In addition, silymarin can be used to treat jaundice disorders by ameliorating the levels of various hepatic enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Moreover, silymarin is able to moderate the immune system, by boosting IL-4, IFN-γ, and IL-10. The hepatoprotective effect of silymarin in poultry farming is poorly understood, although it may be used as a cheap, non-toxic and safe feed additive to manage liver related disorders and to replace synthetic drugs in poultry diets. Hence, this review will allow scientists, veterinarians, researchers, poultry producers to gain a pragmatic edge as well as perspective usage of Silymarin. A main priority is in finding the effective level in poultry whereby it acts as a natural liver tonic in the poultry industry and could reduce veterinary expenses.</description><identifier>ISSN: 0043-9339</identifier><identifier>EISSN: 1743-4777</identifier><identifier>DOI: 10.1017/S0043933917000538</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press on behalf of World's Poultry Science Association</publisher><subject>Alanine ; Alanine transaminase ; Alkaline phosphatase ; Alzheimer's disease ; Animal sciences ; Antioxidants ; Aspartate aminotransferase ; Cirrhosis ; Costs ; Diabetes ; Diabetes mellitus ; Diet ; Disorders ; Enzymes ; Farming ; Feed additives ; Feeds ; Flavonoids ; Free radicals ; Gallbladder ; Gene expression ; hepatic enzymes ; Hepatitis C ; Hepatocellular carcinoma ; Hepatocytes ; hepatoprotective ; Immune response ; Immune system ; Immunomodulation ; Immunosuppressive agents ; Inflammation ; Interferon ; Interleukin 10 ; Interleukin 4 ; Jaundice ; Liver ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Lungs ; Membranes ; Metabolism ; milk thistle ; Mode of action ; Pharmacokinetics ; Pharmacology ; poultry ; Poultry farming ; Protein biosynthesis ; Protein synthesis ; Researchers ; Reviews ; Rodents ; Scavenging ; Seeds ; silymarin ; Stimulation ; Studies ; Toxicity ; Veterinary medicine</subject><ispartof>World's Poultry Science Journal, 2017-09, Vol.73 (3), p.483-492</ispartof><rights>Copyright © World's Poultry Science Association 2017</rights><rights>Copyright © World's Poultry Science Association 2017 2017</rights><rights>Copyright © World's Poultry Science Association 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-ff84535b810b0bb32eb06eeabcc98343d53fa3726ba3087537617511ee7de0a63</citedby><cites>FETCH-LOGICAL-c418t-ff84535b810b0bb32eb06eeabcc98343d53fa3726ba3087537617511ee7de0a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0043933917000538/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,313,314,776,780,788,27899,27901,27902,55603</link.rule.ids></links><search><creatorcontrib>SAEED, M.</creatorcontrib><creatorcontrib>BABAZADEH, D.</creatorcontrib><creatorcontrib>ARIF, M.</creatorcontrib><creatorcontrib>ARAIN, M.A.</creatorcontrib><creatorcontrib>BHUTTO, Z.A.</creatorcontrib><creatorcontrib>SHAR, A.H.</creatorcontrib><creatorcontrib>KAKAR, M.U.</creatorcontrib><creatorcontrib>MANZOOR, R.</creatorcontrib><creatorcontrib>CHAO, S.</creatorcontrib><title>Silymarin: a potent hepatoprotective agent in poultry industry</title><title>World's Poultry Science Journal</title><addtitle>Worlds Poult. Sci. J</addtitle><description>Silymarin is composed of flavonolignans and derived from the dry seed of milk thistle (Silybummarianum) herb. It is used as a hepatoprotective treatment for different liver ailments, mainly cirrhosis, jaundice, growth promotant, alcoholic liver disease, chronic hepatitis C, chronic liver diseases and hepatocellular carcinoma. Reported medicinal properties are anti-inflammatory, immunomodulating, anti-diabetic, antioxidant, low toxicity, promising pharmacokinetics, protective, preventive, regenerative and antifibrotic effects and has been shown to be extremely safe. The mode of action by which silymarin might protect liver cells includes stabilisation of membranes, free radical scavenging, stimulation of hepatocyte protein synthesis and modulation of the immune response. In addition, silymarin can be used to treat jaundice disorders by ameliorating the levels of various hepatic enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Moreover, silymarin is able to moderate the immune system, by boosting IL-4, IFN-γ, and IL-10. The hepatoprotective effect of silymarin in poultry farming is poorly understood, although it may be used as a cheap, non-toxic and safe feed additive to manage liver related disorders and to replace synthetic drugs in poultry diets. Hence, this review will allow scientists, veterinarians, researchers, poultry producers to gain a pragmatic edge as well as perspective usage of Silymarin. A main priority is in finding the effective level in poultry whereby it acts as a natural liver tonic in the poultry industry and could reduce veterinary expenses.</description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Alkaline phosphatase</subject><subject>Alzheimer's disease</subject><subject>Animal sciences</subject><subject>Antioxidants</subject><subject>Aspartate aminotransferase</subject><subject>Cirrhosis</subject><subject>Costs</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diet</subject><subject>Disorders</subject><subject>Enzymes</subject><subject>Farming</subject><subject>Feed additives</subject><subject>Feeds</subject><subject>Flavonoids</subject><subject>Free radicals</subject><subject>Gallbladder</subject><subject>Gene expression</subject><subject>hepatic enzymes</subject><subject>Hepatitis C</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatocytes</subject><subject>hepatoprotective</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunomodulation</subject><subject>Immunosuppressive agents</subject><subject>Inflammation</subject><subject>Interferon</subject><subject>Interleukin 10</subject><subject>Interleukin 4</subject><subject>Jaundice</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Lungs</subject><subject>Membranes</subject><subject>Metabolism</subject><subject>milk thistle</subject><subject>Mode of action</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>poultry</subject><subject>Poultry farming</subject><subject>Protein biosynthesis</subject><subject>Protein synthesis</subject><subject>Researchers</subject><subject>Reviews</subject><subject>Rodents</subject><subject>Scavenging</subject><subject>Seeds</subject><subject>silymarin</subject><subject>Stimulation</subject><subject>Studies</subject><subject>Toxicity</subject><subject>Veterinary medicine</subject><issn>0043-9339</issn><issn>1743-4777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9UE1LxDAQDaLguvoDvBU8VyedtmlFBFn8ggUPq-eQtOmapdvUJFX6703ZPQiip3kz8968mSHknMIlBcquVgAploglZQCQYXFAZpSlGKeMsUMym9rx1D8mJ85tAJKyAJyR25Vux62wuruORNQbrzofvateeNPbkFVef6pIrKey7gJhaL0dA6wHF8ApOWpE69TZPs7J28P96-IpXr48Pi_ulnGV0sLHTVOkGWayoCBBSkyUhFwpIauqLDDFOsNGIEtyKRAKliHLKcsoVYrVCkSOc3KxmxuW-hiU83xjBtsFS07LpGRJCTQJLLpjVdY4Z1XDe6vDcSOnwKc38V9vCpqbnUZ3jbFb8WVsW3MvxtbYxoqu0o7jf3LcW4qttLpeqx-b_an6BmrZfE0</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>SAEED, M.</creator><creator>BABAZADEH, D.</creator><creator>ARIF, M.</creator><creator>ARAIN, M.A.</creator><creator>BHUTTO, Z.A.</creator><creator>SHAR, A.H.</creator><creator>KAKAR, M.U.</creator><creator>MANZOOR, R.</creator><creator>CHAO, S.</creator><general>Cambridge University Press on behalf of World's Poultry Science Association</general><general>Taylor & Francis</general><general>Taylor & Francis 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potent hepatoprotective agent in poultry industry</title><author>SAEED, M. ; BABAZADEH, D. ; ARIF, M. ; ARAIN, M.A. ; BHUTTO, Z.A. ; SHAR, A.H. ; KAKAR, M.U. ; MANZOOR, R. ; CHAO, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-ff84535b810b0bb32eb06eeabcc98343d53fa3726ba3087537617511ee7de0a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Alkaline phosphatase</topic><topic>Alzheimer's disease</topic><topic>Animal sciences</topic><topic>Antioxidants</topic><topic>Aspartate aminotransferase</topic><topic>Cirrhosis</topic><topic>Costs</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diet</topic><topic>Disorders</topic><topic>Enzymes</topic><topic>Farming</topic><topic>Feed additives</topic><topic>Feeds</topic><topic>Flavonoids</topic><topic>Free radicals</topic><topic>Gallbladder</topic><topic>Gene expression</topic><topic>hepatic enzymes</topic><topic>Hepatitis C</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatocytes</topic><topic>hepatoprotective</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunomodulation</topic><topic>Immunosuppressive agents</topic><topic>Inflammation</topic><topic>Interferon</topic><topic>Interleukin 10</topic><topic>Interleukin 4</topic><topic>Jaundice</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Lungs</topic><topic>Membranes</topic><topic>Metabolism</topic><topic>milk thistle</topic><topic>Mode of action</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><topic>poultry</topic><topic>Poultry farming</topic><topic>Protein biosynthesis</topic><topic>Protein synthesis</topic><topic>Researchers</topic><topic>Reviews</topic><topic>Rodents</topic><topic>Scavenging</topic><topic>Seeds</topic><topic>silymarin</topic><topic>Stimulation</topic><topic>Studies</topic><topic>Toxicity</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAEED, M.</creatorcontrib><creatorcontrib>BABAZADEH, D.</creatorcontrib><creatorcontrib>ARIF, M.</creatorcontrib><creatorcontrib>ARAIN, M.A.</creatorcontrib><creatorcontrib>BHUTTO, Z.A.</creatorcontrib><creatorcontrib>SHAR, A.H.</creatorcontrib><creatorcontrib>KAKAR, M.U.</creatorcontrib><creatorcontrib>MANZOOR, R.</creatorcontrib><creatorcontrib>CHAO, S.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical 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Sci. J</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>73</volume><issue>3</issue><spage>483</spage><epage>492</epage><pages>483-492</pages><issn>0043-9339</issn><eissn>1743-4777</eissn><abstract>Silymarin is composed of flavonolignans and derived from the dry seed of milk thistle (Silybummarianum) herb. It is used as a hepatoprotective treatment for different liver ailments, mainly cirrhosis, jaundice, growth promotant, alcoholic liver disease, chronic hepatitis C, chronic liver diseases and hepatocellular carcinoma. Reported medicinal properties are anti-inflammatory, immunomodulating, anti-diabetic, antioxidant, low toxicity, promising pharmacokinetics, protective, preventive, regenerative and antifibrotic effects and has been shown to be extremely safe. The mode of action by which silymarin might protect liver cells includes stabilisation of membranes, free radical scavenging, stimulation of hepatocyte protein synthesis and modulation of the immune response. In addition, silymarin can be used to treat jaundice disorders by ameliorating the levels of various hepatic enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Moreover, silymarin is able to moderate the immune system, by boosting IL-4, IFN-γ, and IL-10. The hepatoprotective effect of silymarin in poultry farming is poorly understood, although it may be used as a cheap, non-toxic and safe feed additive to manage liver related disorders and to replace synthetic drugs in poultry diets. Hence, this review will allow scientists, veterinarians, researchers, poultry producers to gain a pragmatic edge as well as perspective usage of Silymarin. A main priority is in finding the effective level in poultry whereby it acts as a natural liver tonic in the poultry industry and could reduce veterinary expenses.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press on behalf of World's Poultry Science Association</pub><doi>10.1017/S0043933917000538</doi><tpages>10</tpages></addata></record> |
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| source | Cambridge Journals Online |
| subjects | Alanine Alanine transaminase Alkaline phosphatase Alzheimer's disease Animal sciences Antioxidants Aspartate aminotransferase Cirrhosis Costs Diabetes Diabetes mellitus Diet Disorders Enzymes Farming Feed additives Feeds Flavonoids Free radicals Gallbladder Gene expression hepatic enzymes Hepatitis C Hepatocellular carcinoma Hepatocytes hepatoprotective Immune response Immune system Immunomodulation Immunosuppressive agents Inflammation Interferon Interleukin 10 Interleukin 4 Jaundice Liver Liver cancer Liver cirrhosis Liver diseases Lungs Membranes Metabolism milk thistle Mode of action Pharmacokinetics Pharmacology poultry Poultry farming Protein biosynthesis Protein synthesis Researchers Reviews Rodents Scavenging Seeds silymarin Stimulation Studies Toxicity Veterinary medicine |
| title | Silymarin: a potent hepatoprotective agent in poultry industry |
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