The prevalence of Chlamydia trachomatis infection among infertile males and its association with abnormal semen characteristics in Delta State, Nigeria
Chlamydia trachomatis is the most common cause of sexually transmitted diseases that is not of viral origin and there is accumulating evidence of a significant role played by this pathogen in causing male factor infertility. This study thus aimed to determine the prevalence of C. trachomatis among i...
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| Veröffentlicht in: | Tanzania journal of health research 2014-03, Vol.15 (2) |
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| container_title | Tanzania journal of health research |
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| creator | OSAZUWA, FAVOUR AIGUOBARUEGHIAN, OSAMUDIAMEN I ALEKWE, LOUIS IMADE, PAUL E IBADIN, KENNEDY O ABERARE, LEWIS O |
| description | Chlamydia trachomatis is the most common cause of sexually
transmitted diseases that is not of viral origin and there is
accumulating evidence of a significant role played by this pathogen in
causing male factor infertility. This study thus aimed to determine the
prevalence of C. trachomatis among infertile males and to evaluate
their association with fertility status and abnormal semen
characteristics. This study included 215 infertile male subjects who
visited a major fertility clinic in Warri, Delta state, Nigeria. Forty
apparently healthy males without complaints of infertility were
enrolled as controls. Blood samples were collected from patients
aseptically using venous puncture and semen samples were obtained after
masturbation. C. trachomatis IgG antibodies were assayed for in blood
specimens using the Dot rapid Assay Kit flow through Ct cassette and
positive samples were further screened with an enzyme immunoassay
technique. Semen samples were analyzed following World Health
Organization guidelines. Forty-two (19.5%) out of 215 infertile male
subjects were found sero-positive for C. trachomatis. C. trachomatis
was significantly associated with male infertility when compared to
controls (P |
| format | Article |
| fullrecord | <record><control><sourceid>bioline</sourceid><recordid>TN_cdi_bioline_primary_cria_bioline_th_th13012</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>cria_bioline_th_th13012</sourcerecordid><originalsourceid>FETCH-bioline_primary_cria_bioline_th_th130123</originalsourceid><addsrcrecordid>eNqVjEtuAkEMRHtBpJDPHXwAiGaYySh7CGLFBvYj03hoR_1BbYuIk3BdGkQOEKmkUtmvamTG9desnnZt1T6bF5Gfquqarv0cm8vWERwzndBTtARpgLnzGM57RtCM1qWAygIcB7LKKQKGFA_3nJU9QShVAYx7YC0ukizjnfxldYC7mHJhQChQBOuwrCplFmV724UFeUXYKCpNYM2H8sM38zSgF3p_-Kv5WH5v56vpjpPnSP0xc8B87m2B-7-juqK6qepZ8-_CFeSrY9Q</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The prevalence of Chlamydia trachomatis infection among infertile males and its association with abnormal semen characteristics in Delta State, Nigeria</title><source>African Journals Online (Open Access)</source><source>Bioline International</source><source>Alma/SFX Local Collection</source><creator>OSAZUWA, FAVOUR ; AIGUOBARUEGHIAN, OSAMUDIAMEN I ; ALEKWE, LOUIS ; IMADE, PAUL E ; IBADIN, KENNEDY O ; ABERARE, LEWIS O</creator><creatorcontrib>OSAZUWA, FAVOUR ; AIGUOBARUEGHIAN, OSAMUDIAMEN I ; ALEKWE, LOUIS ; IMADE, PAUL E ; IBADIN, KENNEDY O ; ABERARE, LEWIS O</creatorcontrib><description>Chlamydia trachomatis is the most common cause of sexually
transmitted diseases that is not of viral origin and there is
accumulating evidence of a significant role played by this pathogen in
causing male factor infertility. This study thus aimed to determine the
prevalence of C. trachomatis among infertile males and to evaluate
their association with fertility status and abnormal semen
characteristics. This study included 215 infertile male subjects who
visited a major fertility clinic in Warri, Delta state, Nigeria. Forty
apparently healthy males without complaints of infertility were
enrolled as controls. Blood samples were collected from patients
aseptically using venous puncture and semen samples were obtained after
masturbation. C. trachomatis IgG antibodies were assayed for in blood
specimens using the Dot rapid Assay Kit flow through Ct cassette and
positive samples were further screened with an enzyme immunoassay
technique. Semen samples were analyzed following World Health
Organization guidelines. Forty-two (19.5%) out of 215 infertile male
subjects were found sero-positive for C. trachomatis. C. trachomatis
was significantly associated with male infertility when compared to
controls (P<0.001). Age groups 20-29 years (43.3%) and 30-39 years
(22.1%) significantly had higher prevalence of C. trachomatis
(P<0.001), as compared to age groups 40-49 (7.9%) and > 50 years
(3.7%). Sero-positivity for C. trachomatis antibodies was significantly
associated with oligozoospermia (22.5%) and azospermia (61.5%) than
with teratozoospermia (7.3%) and asthenozoospermia (6.3%) (P<0.001).
The prevalence of C. trachomatis among infertile males was high; there
was an association between C. trachomatis infection and poor semen
characteristics and infertility. There is need for routine screening
for the pathogen in males with complaints of infertility so as to rule
out this potentially correctable/reversible cause of infertility.</description><identifier>ISSN: 1821-6404</identifier><language>eng</language><publisher>Health User's Trust Fund (HRUTF)</publisher><subject>Chlamydia trachomatis ; epididimytis ; infertility ; Nigeria ; oligozoospermia ; semen</subject><ispartof>Tanzania journal of health research, 2014-03, Vol.15 (2)</ispartof><rights>Copyright 2013 - Tanzania Journal of Health Research</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,79168</link.rule.ids></links><search><creatorcontrib>OSAZUWA, FAVOUR</creatorcontrib><creatorcontrib>AIGUOBARUEGHIAN, OSAMUDIAMEN I</creatorcontrib><creatorcontrib>ALEKWE, LOUIS</creatorcontrib><creatorcontrib>IMADE, PAUL E</creatorcontrib><creatorcontrib>IBADIN, KENNEDY O</creatorcontrib><creatorcontrib>ABERARE, LEWIS O</creatorcontrib><title>The prevalence of Chlamydia trachomatis infection among infertile males and its association with abnormal semen characteristics in Delta State, Nigeria</title><title>Tanzania journal of health research</title><description>Chlamydia trachomatis is the most common cause of sexually
transmitted diseases that is not of viral origin and there is
accumulating evidence of a significant role played by this pathogen in
causing male factor infertility. This study thus aimed to determine the
prevalence of C. trachomatis among infertile males and to evaluate
their association with fertility status and abnormal semen
characteristics. This study included 215 infertile male subjects who
visited a major fertility clinic in Warri, Delta state, Nigeria. Forty
apparently healthy males without complaints of infertility were
enrolled as controls. Blood samples were collected from patients
aseptically using venous puncture and semen samples were obtained after
masturbation. C. trachomatis IgG antibodies were assayed for in blood
specimens using the Dot rapid Assay Kit flow through Ct cassette and
positive samples were further screened with an enzyme immunoassay
technique. Semen samples were analyzed following World Health
Organization guidelines. Forty-two (19.5%) out of 215 infertile male
subjects were found sero-positive for C. trachomatis. C. trachomatis
was significantly associated with male infertility when compared to
controls (P<0.001). Age groups 20-29 years (43.3%) and 30-39 years
(22.1%) significantly had higher prevalence of C. trachomatis
(P<0.001), as compared to age groups 40-49 (7.9%) and > 50 years
(3.7%). Sero-positivity for C. trachomatis antibodies was significantly
associated with oligozoospermia (22.5%) and azospermia (61.5%) than
with teratozoospermia (7.3%) and asthenozoospermia (6.3%) (P<0.001).
The prevalence of C. trachomatis among infertile males was high; there
was an association between C. trachomatis infection and poor semen
characteristics and infertility. There is need for routine screening
for the pathogen in males with complaints of infertility so as to rule
out this potentially correctable/reversible cause of infertility.</description><subject>Chlamydia trachomatis</subject><subject>epididimytis</subject><subject>infertility</subject><subject>Nigeria</subject><subject>oligozoospermia</subject><subject>semen</subject><issn>1821-6404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNqVjEtuAkEMRHtBpJDPHXwAiGaYySh7CGLFBvYj03hoR_1BbYuIk3BdGkQOEKmkUtmvamTG9desnnZt1T6bF5Gfquqarv0cm8vWERwzndBTtARpgLnzGM57RtCM1qWAygIcB7LKKQKGFA_3nJU9QShVAYx7YC0ukizjnfxldYC7mHJhQChQBOuwrCplFmV724UFeUXYKCpNYM2H8sM38zSgF3p_-Kv5WH5v56vpjpPnSP0xc8B87m2B-7-juqK6qepZ8-_CFeSrY9Q</recordid><startdate>20140311</startdate><enddate>20140311</enddate><creator>OSAZUWA, FAVOUR</creator><creator>AIGUOBARUEGHIAN, OSAMUDIAMEN I</creator><creator>ALEKWE, LOUIS</creator><creator>IMADE, PAUL E</creator><creator>IBADIN, KENNEDY O</creator><creator>ABERARE, LEWIS O</creator><general>Health User's Trust Fund (HRUTF)</general><scope>RBI</scope></search><sort><creationdate>20140311</creationdate><title>The prevalence of Chlamydia trachomatis infection among infertile males and its association with abnormal semen characteristics in Delta State, Nigeria</title><author>OSAZUWA, FAVOUR ; AIGUOBARUEGHIAN, OSAMUDIAMEN I ; ALEKWE, LOUIS ; IMADE, PAUL E ; IBADIN, KENNEDY O ; ABERARE, LEWIS O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-bioline_primary_cria_bioline_th_th130123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Chlamydia trachomatis</topic><topic>epididimytis</topic><topic>infertility</topic><topic>Nigeria</topic><topic>oligozoospermia</topic><topic>semen</topic><toplevel>online_resources</toplevel><creatorcontrib>OSAZUWA, FAVOUR</creatorcontrib><creatorcontrib>AIGUOBARUEGHIAN, OSAMUDIAMEN I</creatorcontrib><creatorcontrib>ALEKWE, LOUIS</creatorcontrib><creatorcontrib>IMADE, PAUL E</creatorcontrib><creatorcontrib>IBADIN, KENNEDY O</creatorcontrib><creatorcontrib>ABERARE, LEWIS O</creatorcontrib><collection>Bioline International</collection><jtitle>Tanzania journal of health research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OSAZUWA, FAVOUR</au><au>AIGUOBARUEGHIAN, OSAMUDIAMEN I</au><au>ALEKWE, LOUIS</au><au>IMADE, PAUL E</au><au>IBADIN, KENNEDY O</au><au>ABERARE, LEWIS O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prevalence of Chlamydia trachomatis infection among infertile males and its association with abnormal semen characteristics in Delta State, Nigeria</atitle><jtitle>Tanzania journal of health research</jtitle><date>2014-03-11</date><risdate>2014</risdate><volume>15</volume><issue>2</issue><issn>1821-6404</issn><abstract>Chlamydia trachomatis is the most common cause of sexually
transmitted diseases that is not of viral origin and there is
accumulating evidence of a significant role played by this pathogen in
causing male factor infertility. This study thus aimed to determine the
prevalence of C. trachomatis among infertile males and to evaluate
their association with fertility status and abnormal semen
characteristics. This study included 215 infertile male subjects who
visited a major fertility clinic in Warri, Delta state, Nigeria. Forty
apparently healthy males without complaints of infertility were
enrolled as controls. Blood samples were collected from patients
aseptically using venous puncture and semen samples were obtained after
masturbation. C. trachomatis IgG antibodies were assayed for in blood
specimens using the Dot rapid Assay Kit flow through Ct cassette and
positive samples were further screened with an enzyme immunoassay
technique. Semen samples were analyzed following World Health
Organization guidelines. Forty-two (19.5%) out of 215 infertile male
subjects were found sero-positive for C. trachomatis. C. trachomatis
was significantly associated with male infertility when compared to
controls (P<0.001). Age groups 20-29 years (43.3%) and 30-39 years
(22.1%) significantly had higher prevalence of C. trachomatis
(P<0.001), as compared to age groups 40-49 (7.9%) and > 50 years
(3.7%). Sero-positivity for C. trachomatis antibodies was significantly
associated with oligozoospermia (22.5%) and azospermia (61.5%) than
with teratozoospermia (7.3%) and asthenozoospermia (6.3%) (P<0.001).
The prevalence of C. trachomatis among infertile males was high; there
was an association between C. trachomatis infection and poor semen
characteristics and infertility. There is need for routine screening
for the pathogen in males with complaints of infertility so as to rule
out this potentially correctable/reversible cause of infertility.</abstract><pub>Health User's Trust Fund (HRUTF)</pub></addata></record> |
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| identifier | ISSN: 1821-6404 |
| ispartof | Tanzania journal of health research, 2014-03, Vol.15 (2) |
| issn | 1821-6404 |
| language | eng |
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| source | African Journals Online (Open Access); Bioline International; Alma/SFX Local Collection |
| subjects | Chlamydia trachomatis epididimytis infertility Nigeria oligozoospermia semen |
| title | The prevalence of Chlamydia trachomatis infection among infertile males and its association with abnormal semen characteristics in Delta State, Nigeria |
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