EVALUATION OF ANTITRYPANOSOMAL AND ANTI INFLAMMATORY ACTIVITIES OF SELECTED NIGERIAN MEDICINAL PLANTS IN MICE
The extracts of nine selected Nigerian medicinal plants were investigated on Trypanosoma brucei brucei infected mice. The anti-inflammatory properties of hexane fraction of the most promising U. chamae extract was assessed by acute oedema of the mice paw model while the modulatory effect of the extr...
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| Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2014-07, Vol.10 (6) |
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| container_title | African journal of traditional, complementary, and alternative medicines |
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| creator | Adelodun, Victoria O Elusiyan, C. A Olorunmola, F. O Adewoyin, F. B Omisore, N. O Adepiti, A. O Agbedahunsi, J. M Adewunmi, C. O |
| description | The extracts of nine selected Nigerian medicinal plants were
investigated on Trypanosoma brucei brucei infected mice. The
anti-inflammatory properties of hexane fraction of the most promising
U. chamae extract was assessed by acute oedema of the mice paw model
while the modulatory effect of the extract on Delayed-Type
Hypersensitivity (DTH) response on in vivo leucocytes mobilization was
evaluated. 'Dose- probing acute toxicity tests' established
an oral and intraperitoneal LD50 for T. ivorensis stem bark as
>1600 < 5000 mg/kg and 100 mg/kg respectively, while the oral
LD50 of Uvaria. chamae was >5000 mg/kg. Extracts of Khaya
senegalensis , Harungana madagascariensis , Terminalia ivorensis,
Curcuma longa , Ocimum gratissimum and Alcornea cordifolia showed
weak anti-trypanosomal effect and did not exhibit significant clearance
in parasitemia at the test dose administered compared with the positive
control (Diminal®). However, the leaf extract of U. chamae and its
hexane fraction demonstrated a significant response (P < 0.01). The
fraction at 1000 mg/kg inhibited oedema by 107%. Uvaria. chamae
demonstrated both anti- trypanosomal and anti-inflammatory properties
by increasing the survival time of infected mice due to reduction in
parasitemia caused by T. brucei brucei. |
| format | Article |
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investigated on Trypanosoma brucei brucei infected mice. The
anti-inflammatory properties of hexane fraction of the most promising
U. chamae extract was assessed by acute oedema of the mice paw model
while the modulatory effect of the extract on Delayed-Type
Hypersensitivity (DTH) response on in vivo leucocytes mobilization was
evaluated. 'Dose- probing acute toxicity tests' established
an oral and intraperitoneal LD50 for T. ivorensis stem bark as
>1600 < 5000 mg/kg and 100 mg/kg respectively, while the oral
LD50 of Uvaria. chamae was >5000 mg/kg. Extracts of Khaya
senegalensis , Harungana madagascariensis , Terminalia ivorensis,
Curcuma longa , Ocimum gratissimum and Alcornea cordifolia showed
weak anti-trypanosomal effect and did not exhibit significant clearance
in parasitemia at the test dose administered compared with the positive
control (Diminal®). However, the leaf extract of U. chamae and its
hexane fraction demonstrated a significant response (P < 0.01). The
fraction at 1000 mg/kg inhibited oedema by 107%. Uvaria. chamae
demonstrated both anti- trypanosomal and anti-inflammatory properties
by increasing the survival time of infected mice due to reduction in
parasitemia caused by T. brucei brucei.</description><identifier>ISSN: 0189-6016</identifier><language>eng</language><publisher>African Ethnomedicines Network</publisher><subject>acute toxicity ; anti-inflammatory ; antitrypanosomiasis ; medicinal plants ; screening</subject><ispartof>African journal of traditional, complementary, and alternative medicines, 2014-07, Vol.10 (6)</ispartof><rights>Copyright [2013] - African Journal of Traditional, Complementary and Alternative Medicines</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,79187</link.rule.ids></links><search><creatorcontrib>Adelodun, Victoria O</creatorcontrib><creatorcontrib>Elusiyan, C. A</creatorcontrib><creatorcontrib>Olorunmola, F. O</creatorcontrib><creatorcontrib>Adewoyin, F. B</creatorcontrib><creatorcontrib>Omisore, N. O</creatorcontrib><creatorcontrib>Adepiti, A. O</creatorcontrib><creatorcontrib>Agbedahunsi, J. M</creatorcontrib><creatorcontrib>Adewunmi, C. O</creatorcontrib><title>EVALUATION OF ANTITRYPANOSOMAL AND ANTI INFLAMMATORY ACTIVITIES OF SELECTED NIGERIAN MEDICINAL PLANTS IN MICE</title><title>African journal of traditional, complementary, and alternative medicines</title><description>The extracts of nine selected Nigerian medicinal plants were
investigated on Trypanosoma brucei brucei infected mice. The
anti-inflammatory properties of hexane fraction of the most promising
U. chamae extract was assessed by acute oedema of the mice paw model
while the modulatory effect of the extract on Delayed-Type
Hypersensitivity (DTH) response on in vivo leucocytes mobilization was
evaluated. 'Dose- probing acute toxicity tests' established
an oral and intraperitoneal LD50 for T. ivorensis stem bark as
>1600 < 5000 mg/kg and 100 mg/kg respectively, while the oral
LD50 of Uvaria. chamae was >5000 mg/kg. Extracts of Khaya
senegalensis , Harungana madagascariensis , Terminalia ivorensis,
Curcuma longa , Ocimum gratissimum and Alcornea cordifolia showed
weak anti-trypanosomal effect and did not exhibit significant clearance
in parasitemia at the test dose administered compared with the positive
control (Diminal®). However, the leaf extract of U. chamae and its
hexane fraction demonstrated a significant response (P < 0.01). The
fraction at 1000 mg/kg inhibited oedema by 107%. Uvaria. chamae
demonstrated both anti- trypanosomal and anti-inflammatory properties
by increasing the survival time of infected mice due to reduction in
parasitemia caused by T. brucei brucei.</description><subject>acute toxicity</subject><subject>anti-inflammatory</subject><subject>antitrypanosomiasis</subject><subject>medicinal plants</subject><subject>screening</subject><issn>0189-6016</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNqVy0sKwjAUheEMFHzuIRtQGotah5f0Vi_kIW0UHJVaFCq-aJ24e6PoAoQDB374WqwbiGgxmgVi1mG9pjkFQRiJybzLLrgFtQFH1nCbcDCOXLpbg7GZ1aB8iD-Rk0kUaA3OpjsO0tGWHGH2RhkqlA5jbmiJKYHhGmOSZLxfK68zr7kmiQPWPhbn5jD8fp-NE3RyNdpXt3N1PeT3uroU9TMv66rIf_FR-olQTEX4N3gBn5tI7Q</recordid><startdate>20140716</startdate><enddate>20140716</enddate><creator>Adelodun, Victoria O</creator><creator>Elusiyan, C. A</creator><creator>Olorunmola, F. O</creator><creator>Adewoyin, F. B</creator><creator>Omisore, N. O</creator><creator>Adepiti, A. O</creator><creator>Agbedahunsi, J. M</creator><creator>Adewunmi, C. O</creator><general>African Ethnomedicines Network</general><scope>RBI</scope></search><sort><creationdate>20140716</creationdate><title>EVALUATION OF ANTITRYPANOSOMAL AND ANTI INFLAMMATORY ACTIVITIES OF SELECTED NIGERIAN MEDICINAL PLANTS IN MICE</title><author>Adelodun, Victoria O ; Elusiyan, C. A ; Olorunmola, F. O ; Adewoyin, F. B ; Omisore, N. O ; Adepiti, A. O ; Agbedahunsi, J. M ; Adewunmi, C. O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-bioline_primary_cria_bioline_tc_tc131513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>acute toxicity</topic><topic>anti-inflammatory</topic><topic>antitrypanosomiasis</topic><topic>medicinal plants</topic><topic>screening</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adelodun, Victoria O</creatorcontrib><creatorcontrib>Elusiyan, C. A</creatorcontrib><creatorcontrib>Olorunmola, F. O</creatorcontrib><creatorcontrib>Adewoyin, F. B</creatorcontrib><creatorcontrib>Omisore, N. O</creatorcontrib><creatorcontrib>Adepiti, A. O</creatorcontrib><creatorcontrib>Agbedahunsi, J. M</creatorcontrib><creatorcontrib>Adewunmi, C. O</creatorcontrib><collection>Bioline International</collection><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adelodun, Victoria O</au><au>Elusiyan, C. A</au><au>Olorunmola, F. O</au><au>Adewoyin, F. B</au><au>Omisore, N. O</au><au>Adepiti, A. O</au><au>Agbedahunsi, J. M</au><au>Adewunmi, C. O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EVALUATION OF ANTITRYPANOSOMAL AND ANTI INFLAMMATORY ACTIVITIES OF SELECTED NIGERIAN MEDICINAL PLANTS IN MICE</atitle><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle><date>2014-07-16</date><risdate>2014</risdate><volume>10</volume><issue>6</issue><issn>0189-6016</issn><abstract>The extracts of nine selected Nigerian medicinal plants were
investigated on Trypanosoma brucei brucei infected mice. The
anti-inflammatory properties of hexane fraction of the most promising
U. chamae extract was assessed by acute oedema of the mice paw model
while the modulatory effect of the extract on Delayed-Type
Hypersensitivity (DTH) response on in vivo leucocytes mobilization was
evaluated. 'Dose- probing acute toxicity tests' established
an oral and intraperitoneal LD50 for T. ivorensis stem bark as
>1600 < 5000 mg/kg and 100 mg/kg respectively, while the oral
LD50 of Uvaria. chamae was >5000 mg/kg. Extracts of Khaya
senegalensis , Harungana madagascariensis , Terminalia ivorensis,
Curcuma longa , Ocimum gratissimum and Alcornea cordifolia showed
weak anti-trypanosomal effect and did not exhibit significant clearance
in parasitemia at the test dose administered compared with the positive
control (Diminal®). However, the leaf extract of U. chamae and its
hexane fraction demonstrated a significant response (P < 0.01). The
fraction at 1000 mg/kg inhibited oedema by 107%. Uvaria. chamae
demonstrated both anti- trypanosomal and anti-inflammatory properties
by increasing the survival time of infected mice due to reduction in
parasitemia caused by T. brucei brucei.</abstract><pub>African Ethnomedicines Network</pub></addata></record> |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Bioline International; PubMed Central |
| subjects | acute toxicity anti-inflammatory antitrypanosomiasis medicinal plants screening |
| title | EVALUATION OF ANTITRYPANOSOMAL AND ANTI INFLAMMATORY ACTIVITIES OF SELECTED NIGERIAN MEDICINAL PLANTS IN MICE |
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