Ovarian stimulation medications and patients' responses as prognostic factors in IUI-treated infertile Saudi patients
Background: Intrauterine Insemination (IUI) remains the first thought of infertility treatment. Objective: To compare the stimulation effects and Pregnancy rate (PR) outcomes of two ovulation induction (OI) medications, human-derived menopausal gonadotrophins (hMGH), Merional (MER), and recombinant...
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Veröffentlicht in: | Iranian journal of reproductive medicine 2015-01, Vol.12 (7) |
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Zusammenfassung: | Background: Intrauterine Insemination (IUI) remains the first thought
of infertility treatment. Objective: To compare the stimulation effects
and Pregnancy rate (PR) outcomes of two ovulation induction (OI)
medications, human-derived menopausal gonadotrophins (hMGH), Merional
(MER), and recombinant follicular stimulating hormone (rFSH), Puregon
(PUR), in a cohort of Saudi infertile patients, for better
predictability of treatment results. Materials and Methods: During a
24-month period, 296 women underwent IUI single treatments. PR's
were correlated with the type of stimulation medication that were
prospectively and randomly assigned to each patient, and with the
number and size of maturing follicles detected on the hCG injection
day. Results: MER and PUR needed comparable number of days
(9.26±4.74 and 9.73±6.27 respectively) before follicles were
ready for IUI, although the average amount used from MER, 1199.90 IU,
was about double that was used from PUR, 621.08 IU. The overall PR in
case of PUR however was nearly double that of MER, 13.28% and 7.14%
respectively. The best PR, 16.22%, occurred when the follicles matured
within 12-13 days. Three follicles of at least 15-mm diameter on the
hCG day had better PR's than one or two, however when the
follicles' diameters were at least 18-mm, PR was significantly
higher, (p=0.013). Conclusion: MER and PUR had comparable stimulation
effects; however PUR had noticeably higher PR. The best PR occurred
when the follicles matured within 12-13 days. PR in case of three
maturing follicles on the hCG day was better than only one or two, and
significantly better when their diameters were at least 18 mm. |
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ISSN: | 1680-6433 |