Anti-inflammatory and Anti-ulcerogenic Effect of Crotalaria juncea Linn. in Albino Rats
The aim of this study was to evaluate the antiarthritic activity of ethanolic extract of the leaves of Crotalaria juncea (CJE) in Complete Freund's Adjuvant (CFA) induced arthritis model in rats, and also to evaluate anti-ulcerogenic activity of CJE.Arthritis was induced in male albino Wistar...
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| Veröffentlicht in: | Iranian journal of pharmacology & therapeutics 2007-08, Vol.5 (2) |
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| container_title | Iranian journal of pharmacology & therapeutics |
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| creator | Ashok, Purnima Rajani, G.P Arulmozhi, S Hulkoti, Basavaraj Desai, B.G Rajendran, R |
| description | The aim of this study was to evaluate the antiarthritic activity of
ethanolic extract of the leaves of Crotalaria juncea (CJE) in
Complete Freund's Adjuvant (CFA) induced arthritis model in rats, and
also to evaluate anti-ulcerogenic activity of CJE.Arthritis was induced
in male albino Wistar rats by injection of CFA (0.1 mL) into the left
foot pad of the animals. Treatment with CJE at 200 and 400 mg/kg and
standard indomethacin (0.3 mg/kg) was started on the same day and
continued up to day 12. The paw volume was measured on day 1, 5, 12 and
21 for both the paws and antiarthritic activity was evaluated.
Anti-ulcerogenic potential of CJE was also evaluated. For possible
mechanism of anti-ulcerogenic potential, appetite suppressant activity
was recorded. The drug CJE produced reduction in the inflammation of
the paw produced due to CFA. The antiarthritic action started on the
day 5 and continued till day 12 and the activity was comparable to that
of the standard on both days. In indomethacin treated animals ulcer was
observed, where as CJE was found to protect the animals from ulcer
formation which may be due to appetite suppressant activity.CJE
significantly inhibited adjuvant induced arthritis and has significant
anti-inflammatory effect (p |
| format | Article |
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ethanolic extract of the leaves of Crotalaria juncea (CJE) in
Complete Freund's Adjuvant (CFA) induced arthritis model in rats, and
also to evaluate anti-ulcerogenic activity of CJE.Arthritis was induced
in male albino Wistar rats by injection of CFA (0.1 mL) into the left
foot pad of the animals. Treatment with CJE at 200 and 400 mg/kg and
standard indomethacin (0.3 mg/kg) was started on the same day and
continued up to day 12. The paw volume was measured on day 1, 5, 12 and
21 for both the paws and antiarthritic activity was evaluated.
Anti-ulcerogenic potential of CJE was also evaluated. For possible
mechanism of anti-ulcerogenic potential, appetite suppressant activity
was recorded. The drug CJE produced reduction in the inflammation of
the paw produced due to CFA. The antiarthritic action started on the
day 5 and continued till day 12 and the activity was comparable to that
of the standard on both days. In indomethacin treated animals ulcer was
observed, where as CJE was found to protect the animals from ulcer
formation which may be due to appetite suppressant activity.CJE
significantly inhibited adjuvant induced arthritis and has significant
anti-inflammatory effect (p<0.001). It has anti-ulcerogenic property
compared to indomethacin, which may be due to appetite suppressant
activity.</description><identifier>ISSN: 1735-2657</identifier><identifier>EISSN: 1735-2657</identifier><language>eng</language><publisher>Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)</publisher><subject>Crotalaria juncea, Antiarthritic, CFA</subject><ispartof>Iranian journal of pharmacology & therapeutics, 2007-08, Vol.5 (2)</ispartof><rights>Copyright 2006 - Razi Institute for Drug Research (RIDR)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Ashok, Purnima</creatorcontrib><creatorcontrib>Rajani, G.P</creatorcontrib><creatorcontrib>Arulmozhi, S</creatorcontrib><creatorcontrib>Hulkoti, Basavaraj</creatorcontrib><creatorcontrib>Desai, B.G</creatorcontrib><creatorcontrib>Rajendran, R</creatorcontrib><title>Anti-inflammatory and Anti-ulcerogenic Effect of Crotalaria juncea Linn. in Albino Rats</title><title>Iranian journal of pharmacology & therapeutics</title><description>The aim of this study was to evaluate the antiarthritic activity of
ethanolic extract of the leaves of Crotalaria juncea (CJE) in
Complete Freund's Adjuvant (CFA) induced arthritis model in rats, and
also to evaluate anti-ulcerogenic activity of CJE.Arthritis was induced
in male albino Wistar rats by injection of CFA (0.1 mL) into the left
foot pad of the animals. Treatment with CJE at 200 and 400 mg/kg and
standard indomethacin (0.3 mg/kg) was started on the same day and
continued up to day 12. The paw volume was measured on day 1, 5, 12 and
21 for both the paws and antiarthritic activity was evaluated.
Anti-ulcerogenic potential of CJE was also evaluated. For possible
mechanism of anti-ulcerogenic potential, appetite suppressant activity
was recorded. The drug CJE produced reduction in the inflammation of
the paw produced due to CFA. The antiarthritic action started on the
day 5 and continued till day 12 and the activity was comparable to that
of the standard on both days. In indomethacin treated animals ulcer was
observed, where as CJE was found to protect the animals from ulcer
formation which may be due to appetite suppressant activity.CJE
significantly inhibited adjuvant induced arthritis and has significant
anti-inflammatory effect (p<0.001). It has anti-ulcerogenic property
compared to indomethacin, which may be due to appetite suppressant
activity.</description><subject>Crotalaria juncea, Antiarthritic, CFA</subject><issn>1735-2657</issn><issn>1735-2657</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNqVjEsKwkAQRAdRMH7u0BdIiPmYdRDFhStx5SZ0xhlpmfTIZLLIbTyLJzOIiFuh4BUPqkYiWBVpHibrvBj_9KmYte0tjrM0ydNAnEv2FBJrg02D3roekC_wtp2RytmrYpKw1VpJD1bDxlmPBh0h3DqWCuFAzBE8H0AMpamJLRzRtwsx0WhatfxwLqLd9rTZhzVZQ6yqu6MGXV_J4av6Sj8kXsdJlv49eAHtCU5V</recordid><startdate>20070810</startdate><enddate>20070810</enddate><creator>Ashok, Purnima</creator><creator>Rajani, G.P</creator><creator>Arulmozhi, S</creator><creator>Hulkoti, Basavaraj</creator><creator>Desai, B.G</creator><creator>Rajendran, R</creator><general>Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)</general><scope>RBI</scope></search><sort><creationdate>20070810</creationdate><title>Anti-inflammatory and Anti-ulcerogenic Effect of Crotalaria juncea Linn. in Albino Rats</title><author>Ashok, Purnima ; Rajani, G.P ; Arulmozhi, S ; Hulkoti, Basavaraj ; Desai, B.G ; Rajendran, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-bioline_primary_cria_bioline_pt_pt060243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Crotalaria juncea, Antiarthritic, CFA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ashok, Purnima</creatorcontrib><creatorcontrib>Rajani, G.P</creatorcontrib><creatorcontrib>Arulmozhi, S</creatorcontrib><creatorcontrib>Hulkoti, Basavaraj</creatorcontrib><creatorcontrib>Desai, B.G</creatorcontrib><creatorcontrib>Rajendran, R</creatorcontrib><collection>Bioline International</collection><jtitle>Iranian journal of pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ashok, Purnima</au><au>Rajani, G.P</au><au>Arulmozhi, S</au><au>Hulkoti, Basavaraj</au><au>Desai, B.G</au><au>Rajendran, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory and Anti-ulcerogenic Effect of Crotalaria juncea Linn. in Albino Rats</atitle><jtitle>Iranian journal of pharmacology & therapeutics</jtitle><date>2007-08-10</date><risdate>2007</risdate><volume>5</volume><issue>2</issue><issn>1735-2657</issn><eissn>1735-2657</eissn><abstract>The aim of this study was to evaluate the antiarthritic activity of
ethanolic extract of the leaves of Crotalaria juncea (CJE) in
Complete Freund's Adjuvant (CFA) induced arthritis model in rats, and
also to evaluate anti-ulcerogenic activity of CJE.Arthritis was induced
in male albino Wistar rats by injection of CFA (0.1 mL) into the left
foot pad of the animals. Treatment with CJE at 200 and 400 mg/kg and
standard indomethacin (0.3 mg/kg) was started on the same day and
continued up to day 12. The paw volume was measured on day 1, 5, 12 and
21 for both the paws and antiarthritic activity was evaluated.
Anti-ulcerogenic potential of CJE was also evaluated. For possible
mechanism of anti-ulcerogenic potential, appetite suppressant activity
was recorded. The drug CJE produced reduction in the inflammation of
the paw produced due to CFA. The antiarthritic action started on the
day 5 and continued till day 12 and the activity was comparable to that
of the standard on both days. In indomethacin treated animals ulcer was
observed, where as CJE was found to protect the animals from ulcer
formation which may be due to appetite suppressant activity.CJE
significantly inhibited adjuvant induced arthritis and has significant
anti-inflammatory effect (p<0.001). It has anti-ulcerogenic property
compared to indomethacin, which may be due to appetite suppressant
activity.</abstract><pub>Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1735-2657 |
| ispartof | Iranian journal of pharmacology & therapeutics, 2007-08, Vol.5 (2) |
| issn | 1735-2657 1735-2657 |
| language | eng |
| recordid | cdi_bioline_primary_cria_bioline_pt_pt06024 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Crotalaria juncea, Antiarthritic, CFA |
| title | Anti-inflammatory and Anti-ulcerogenic Effect of Crotalaria juncea Linn. in Albino Rats |
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