Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats
Ethanol-induced acute gastric ulceration (EIGU) is widely studied. ATP dependent potassium channel (KATP) modulators are thought to interfere with some physiologic functions of the stomach. We have studied the effects of different doses of KATP modulators (diazoxide as agonist and glibenclamide as a...
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| Veröffentlicht in: | Iranian journal of pharmacology & therapeutics 2005-11, Vol.1 (1) |
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| container_title | Iranian journal of pharmacology & therapeutics |
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| creator | Majid Rahgozar, Hamid Reza Pazoki Toroudi, azam Bakhtiarian, and Bijan Djahanguiri |
| description | Ethanol-induced acute gastric ulceration (EIGU) is widely studied. ATP
dependent potassium channel (KATP) modulators are thought to interfere
with some physiologic functions of the stomach. We have studied the
effects of different doses of KATP modulators (diazoxide as agonist and
glibenclamide as antagonist) on EIGU in rats. Gastric lesions were
quantified. Fasting blood glucose (FBS) levels were measured
enzymatically. EIGU was prevented by diazoxide and aggravated by
glibenclamide. Diazoxide increased and glibenclamide decreased FBS
respectively. The present study shows that KATP modulators are involved
in the production of EIGU with a mechanism which remains to be
elucidated. |
| format | Article |
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dependent potassium channel (KATP) modulators are thought to interfere
with some physiologic functions of the stomach. We have studied the
effects of different doses of KATP modulators (diazoxide as agonist and
glibenclamide as antagonist) on EIGU in rats. Gastric lesions were
quantified. Fasting blood glucose (FBS) levels were measured
enzymatically. EIGU was prevented by diazoxide and aggravated by
glibenclamide. Diazoxide increased and glibenclamide decreased FBS
respectively. The present study shows that KATP modulators are involved
in the production of EIGU with a mechanism which remains to be
elucidated.</description><identifier>ISSN: 1735-2657</identifier><identifier>EISSN: 1735-2657</identifier><language>eng</language><publisher>Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)</publisher><subject>ethanol, potassium channel modulators, rats, stomach ulceration</subject><ispartof>Iranian journal of pharmacology & therapeutics, 2005-11, Vol.1 (1)</ispartof><rights>Copyright 2002 - Razi Institute for Drug Research (RIDR)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,79169</link.rule.ids></links><search><creatorcontrib>Majid Rahgozar, Hamid Reza Pazoki Toroudi, azam Bakhtiarian, and Bijan Djahanguiri</creatorcontrib><title>Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats</title><title>Iranian journal of pharmacology & therapeutics</title><description>Ethanol-induced acute gastric ulceration (EIGU) is widely studied. ATP
dependent potassium channel (KATP) modulators are thought to interfere
with some physiologic functions of the stomach. We have studied the
effects of different doses of KATP modulators (diazoxide as agonist and
glibenclamide as antagonist) on EIGU in rats. Gastric lesions were
quantified. Fasting blood glucose (FBS) levels were measured
enzymatically. EIGU was prevented by diazoxide and aggravated by
glibenclamide. Diazoxide increased and glibenclamide decreased FBS
respectively. The present study shows that KATP modulators are involved
in the production of EIGU with a mechanism which remains to be
elucidated.</description><subject>ethanol, potassium channel modulators, rats, stomach ulceration</subject><issn>1735-2657</issn><issn>1735-2657</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNqVi80KwjAQhIMo-PsO-wBWYmvtWbT-4EGR6rWs7YorMS1JFPXp7UHEqzAw880wNdEaRkHo-eMwqv_kpmhbe5FyFPhh0BKHGeOreHBOfUBYT5ItTM-oNSnYlKTJ9GFr6E7aUQ6xq6ZCeSud37KKF2id4Qz2KiODjgsNrGGHznZF44TKUu_jHTGYx8l06R25UKwpLQ1f0TzTzDCm39JVkr6UfvD34Q3S7Uu5</recordid><startdate>20051121</startdate><enddate>20051121</enddate><creator>Majid Rahgozar, Hamid Reza Pazoki Toroudi, azam Bakhtiarian, and Bijan Djahanguiri</creator><general>Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)</general><scope>RBI</scope></search><sort><creationdate>20051121</creationdate><title>Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats</title><author>Majid Rahgozar, Hamid Reza Pazoki Toroudi, azam Bakhtiarian, and Bijan Djahanguiri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-bioline_primary_cria_bioline_pt_pt020023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>ethanol, potassium channel modulators, rats, stomach ulceration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Majid Rahgozar, Hamid Reza Pazoki Toroudi, azam Bakhtiarian, and Bijan Djahanguiri</creatorcontrib><collection>Bioline International</collection><jtitle>Iranian journal of pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Majid Rahgozar, Hamid Reza Pazoki Toroudi, azam Bakhtiarian, and Bijan Djahanguiri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats</atitle><jtitle>Iranian journal of pharmacology & therapeutics</jtitle><date>2005-11-21</date><risdate>2005</risdate><volume>1</volume><issue>1</issue><issn>1735-2657</issn><eissn>1735-2657</eissn><abstract>Ethanol-induced acute gastric ulceration (EIGU) is widely studied. ATP
dependent potassium channel (KATP) modulators are thought to interfere
with some physiologic functions of the stomach. We have studied the
effects of different doses of KATP modulators (diazoxide as agonist and
glibenclamide as antagonist) on EIGU in rats. Gastric lesions were
quantified. Fasting blood glucose (FBS) levels were measured
enzymatically. EIGU was prevented by diazoxide and aggravated by
glibenclamide. Diazoxide increased and glibenclamide decreased FBS
respectively. The present study shows that KATP modulators are involved
in the production of EIGU with a mechanism which remains to be
elucidated.</abstract><pub>Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)</pub></addata></record> |
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| ispartof | Iranian journal of pharmacology & therapeutics, 2005-11, Vol.1 (1) |
| issn | 1735-2657 1735-2657 |
| language | eng |
| recordid | cdi_bioline_primary_cria_bioline_pt_pt02002 |
| source | Bioline International; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | ethanol, potassium channel modulators, rats, stomach ulceration |
| title | Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats |
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