Effect of losartan on albuminuria, peripheral and autonomic neuropathy in normotensive microalbuminuric type 2 diabetics
Background: Angiotensin converting enzyme (ACE) inhibitors are emerging as effective agents for preventing microvascular complications of diabetes. Losartan (angiotensin II antagonist) has an antihypertensive efficacy equivalent to ACE inhibitors, however its role in microvascular complications is n...
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| Veröffentlicht in: | Neurology India 2004-02, Vol.51 (3) |
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| creator | Kubba S, Agarwal SKK, Prakash A, Puri V, Babbar R, Anuradha S |
| description | Background: Angiotensin converting enzyme (ACE) inhibitors are emerging
as effective agents for preventing microvascular complications of
diabetes. Losartan (angiotensin II antagonist) has an antihypertensive
efficacy equivalent to ACE inhibitors, however its role in
microvascular complications is not yet known. Material and Methods: We
studied the efficacy of losartan (50 mg once daily for 12 weeks) on
albuminuria, peripheral and autonomic neuropathy in 25 normotensive
microalbuminuric type 2 diabetics who were asymptomatic for neuropathy.
Results: Mean age was 46.6 ± 4.34 years with the average duration
of diabetes being 8.1 ± 1.54 years. Albuminuria improved
significantly from 54 ± 9.35 mg/L to 32.8 ± 25 mg/L (Paired
student's t-test, P=0.0005) after therapy. Autonomic neuropathy was
observed in 64% while 76% had peripheral neuropathy; but there was no
improvement with losartan. The duration of diabetes had a negative
correlation with autonomic neuropathy. It also had a similar negative
correlation with median and common peroneal nerve motor conduction
velocities (Pearson's correlation coefficient, r = -0.53, P |
| format | Article |
| fullrecord | <record><control><sourceid>bioline</sourceid><recordid>TN_cdi_bioline_primary_cria_bioline_ni_ni03115</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>cria_bioline_ni_ni03115</sourcerecordid><originalsourceid>FETCH-bioline_primary_cria_bioline_ni_ni031153</originalsourceid><addsrcrecordid>eNqVTkFqw0AQ20MLSdr8YR7QBNtLg-8hpQ_I3Yw3YzJhPbPMrkP8-_rQ0HNBICQhoRe3rqqm3fm2PazcJufbIr2vm7V7nIaBQgEdIGpGKyigAhj7aWSZjPEDEhmnKxlGQLkATkVFRw4gNJkmLNcZWEDURi0kme8ES2z6txKgzImggQtjT4VDfnevA8ZM219-c_uv0_n4vetZIwt1yXhEm7uwfOiepvCCytf1p_934Qc3DVjl</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effect of losartan on albuminuria, peripheral and autonomic neuropathy in normotensive microalbuminuric type 2 diabetics</title><source>Bioline International</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Kubba S, Agarwal SKK, Prakash A, Puri V, Babbar R, Anuradha S</creator><creatorcontrib>Kubba S, Agarwal SKK, Prakash A, Puri V, Babbar R, Anuradha S</creatorcontrib><description>Background: Angiotensin converting enzyme (ACE) inhibitors are emerging
as effective agents for preventing microvascular complications of
diabetes. Losartan (angiotensin II antagonist) has an antihypertensive
efficacy equivalent to ACE inhibitors, however its role in
microvascular complications is not yet known. Material and Methods: We
studied the efficacy of losartan (50 mg once daily for 12 weeks) on
albuminuria, peripheral and autonomic neuropathy in 25 normotensive
microalbuminuric type 2 diabetics who were asymptomatic for neuropathy.
Results: Mean age was 46.6 ± 4.34 years with the average duration
of diabetes being 8.1 ± 1.54 years. Albuminuria improved
significantly from 54 ± 9.35 mg/L to 32.8 ± 25 mg/L (Paired
student's t-test, P=0.0005) after therapy. Autonomic neuropathy was
observed in 64% while 76% had peripheral neuropathy; but there was no
improvement with losartan. The duration of diabetes had a negative
correlation with autonomic neuropathy. It also had a similar negative
correlation with median and common peroneal nerve motor conduction
velocities (Pearson's correlation coefficient, r = -0.53, P<0.01 and
r = -0.56, P<0.01 respectively) implying that autonomic and
peripheral neuropathy worsen as a diabetic ages. However, no
correlation existed between albuminuria and autonomic or peripheral
nerve function. Conclusion: Autonomic and peripheral neuropathy are
highly prevalent in normotensive microalbuminuric diabetic patients.
Losartan remarkably improves albuminuria but a similar benefit in
autonomic or peripheral neuropathy is not seen over 12 weeks. The
future may see a defining role for losartan in microvascular
complications in normotensive diabetics.</description><identifier>ISSN: 0028-3886</identifier><language>eng</language><publisher>Medknow Publications on behalf of the Neurological Society of India</publisher><ispartof>Neurology India, 2004-02, Vol.51 (3)</ispartof><rights>Copyright 2003 Neurology India. Online full text also at http://www.neurologyindia.com</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,79168</link.rule.ids></links><search><creatorcontrib>Kubba S, Agarwal SKK, Prakash A, Puri V, Babbar R, Anuradha S</creatorcontrib><title>Effect of losartan on albuminuria, peripheral and autonomic neuropathy in normotensive microalbuminuric type 2 diabetics</title><title>Neurology India</title><description>Background: Angiotensin converting enzyme (ACE) inhibitors are emerging
as effective agents for preventing microvascular complications of
diabetes. Losartan (angiotensin II antagonist) has an antihypertensive
efficacy equivalent to ACE inhibitors, however its role in
microvascular complications is not yet known. Material and Methods: We
studied the efficacy of losartan (50 mg once daily for 12 weeks) on
albuminuria, peripheral and autonomic neuropathy in 25 normotensive
microalbuminuric type 2 diabetics who were asymptomatic for neuropathy.
Results: Mean age was 46.6 ± 4.34 years with the average duration
of diabetes being 8.1 ± 1.54 years. Albuminuria improved
significantly from 54 ± 9.35 mg/L to 32.8 ± 25 mg/L (Paired
student's t-test, P=0.0005) after therapy. Autonomic neuropathy was
observed in 64% while 76% had peripheral neuropathy; but there was no
improvement with losartan. The duration of diabetes had a negative
correlation with autonomic neuropathy. It also had a similar negative
correlation with median and common peroneal nerve motor conduction
velocities (Pearson's correlation coefficient, r = -0.53, P<0.01 and
r = -0.56, P<0.01 respectively) implying that autonomic and
peripheral neuropathy worsen as a diabetic ages. However, no
correlation existed between albuminuria and autonomic or peripheral
nerve function. Conclusion: Autonomic and peripheral neuropathy are
highly prevalent in normotensive microalbuminuric diabetic patients.
Losartan remarkably improves albuminuria but a similar benefit in
autonomic or peripheral neuropathy is not seen over 12 weeks. The
future may see a defining role for losartan in microvascular
complications in normotensive diabetics.</description><issn>0028-3886</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNqVTkFqw0AQ20MLSdr8YR7QBNtLg-8hpQ_I3Yw3YzJhPbPMrkP8-_rQ0HNBICQhoRe3rqqm3fm2PazcJufbIr2vm7V7nIaBQgEdIGpGKyigAhj7aWSZjPEDEhmnKxlGQLkATkVFRw4gNJkmLNcZWEDURi0kme8ES2z6txKgzImggQtjT4VDfnevA8ZM219-c_uv0_n4vetZIwt1yXhEm7uwfOiepvCCytf1p_934Qc3DVjl</recordid><startdate>20040206</startdate><enddate>20040206</enddate><creator>Kubba S, Agarwal SKK, Prakash A, Puri V, Babbar R, Anuradha S</creator><general>Medknow Publications on behalf of the Neurological Society of India</general><scope>RBI</scope></search><sort><creationdate>20040206</creationdate><title>Effect of losartan on albuminuria, peripheral and autonomic neuropathy in normotensive microalbuminuric type 2 diabetics</title><author>Kubba S, Agarwal SKK, Prakash A, Puri V, Babbar R, Anuradha S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-bioline_primary_cria_bioline_ni_ni031153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kubba S, Agarwal SKK, Prakash A, Puri V, Babbar R, Anuradha S</creatorcontrib><collection>Bioline International</collection><jtitle>Neurology India</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kubba S, Agarwal SKK, Prakash A, Puri V, Babbar R, Anuradha S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of losartan on albuminuria, peripheral and autonomic neuropathy in normotensive microalbuminuric type 2 diabetics</atitle><jtitle>Neurology India</jtitle><date>2004-02-06</date><risdate>2004</risdate><volume>51</volume><issue>3</issue><issn>0028-3886</issn><abstract>Background: Angiotensin converting enzyme (ACE) inhibitors are emerging
as effective agents for preventing microvascular complications of
diabetes. Losartan (angiotensin II antagonist) has an antihypertensive
efficacy equivalent to ACE inhibitors, however its role in
microvascular complications is not yet known. Material and Methods: We
studied the efficacy of losartan (50 mg once daily for 12 weeks) on
albuminuria, peripheral and autonomic neuropathy in 25 normotensive
microalbuminuric type 2 diabetics who were asymptomatic for neuropathy.
Results: Mean age was 46.6 ± 4.34 years with the average duration
of diabetes being 8.1 ± 1.54 years. Albuminuria improved
significantly from 54 ± 9.35 mg/L to 32.8 ± 25 mg/L (Paired
student's t-test, P=0.0005) after therapy. Autonomic neuropathy was
observed in 64% while 76% had peripheral neuropathy; but there was no
improvement with losartan. The duration of diabetes had a negative
correlation with autonomic neuropathy. It also had a similar negative
correlation with median and common peroneal nerve motor conduction
velocities (Pearson's correlation coefficient, r = -0.53, P<0.01 and
r = -0.56, P<0.01 respectively) implying that autonomic and
peripheral neuropathy worsen as a diabetic ages. However, no
correlation existed between albuminuria and autonomic or peripheral
nerve function. Conclusion: Autonomic and peripheral neuropathy are
highly prevalent in normotensive microalbuminuric diabetic patients.
Losartan remarkably improves albuminuria but a similar benefit in
autonomic or peripheral neuropathy is not seen over 12 weeks. The
future may see a defining role for losartan in microvascular
complications in normotensive diabetics.</abstract><pub>Medknow Publications on behalf of the Neurological Society of India</pub></addata></record> |
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| language | eng |
| recordid | cdi_bioline_primary_cria_bioline_ni_ni03115 |
| source | Bioline International; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| title | Effect of losartan on albuminuria, peripheral and autonomic neuropathy in normotensive microalbuminuric type 2 diabetics |
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