Seroprevalence and trends in transfusion transmissible infections among voluntary non-remunerated blood donors at the Malawi Blood Transfusion Service-a time trend study
Introduction Collecting blood from voluntary non-remunerated blood donors from low risk populations is a key strategy for blood safety. Identifying such populations involves analysis of population and blood donor data to identify risk factors for transfusion transmissible infections (TTIs). There ar...
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| creator | M'baya, Bridon Jumbe, Vincent Samuel, Vincent M'bwana, Robert Mangani, Charles |
| description | Introduction Collecting blood from voluntary non-remunerated blood
donors from low risk populations is a key strategy for blood safety.
Identifying such populations involves analysis of population and blood
donor data to identify risk factors for transfusion transmissible
infections (TTIs). There are no recent seroprevalence statistics for
blood donors in Malawi. This study fills this gap by describing
characteristics of blood donors, trend of annual prevalence of HIV,
HBV, HCV and syphilis and factors associated with each TTI. Methods
Retrospective analysis of blood donors' records in the MBTS
database from 2011 to 2015 was undertaken. Summary statistics were
performed to describe characteristics of the blood donors. Univariable
and multivariable logistic regression analyses were performed to
determine association between prevalence of infections and
socio-demographic factors. Time trend analysis was done to assess
changes in prevalence. P-value |
| format | Article |
| fullrecord | <record><control><sourceid>bioline</sourceid><recordid>TN_cdi_bioline_primary_cria_bioline_mm_mm19021</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>cria_bioline_mm_mm19021</sourcerecordid><originalsourceid>FETCH-bioline_primary_cria_bioline_mm_mm190213</originalsourceid><addsrcrecordid>eNqVTstKxEAQnIOC6-Mf-gciSSQuuSqKF0_uPXQyHW2Z6V6mJ5H9JP_SQVfwKjRUUVVN1YnbNH3fVdv2tj1z52bvdd319bbbuM8XSrpPtGIgmQhQPORE4g1YCkOxeTHWI49sxmOgYs405aIbYFR5hVXDIhnTAUSlShQXoYSZPIxB1YNX0VTCGfIbwTMG_GC4-7Z2f1rKnJUnqhAyR_qZApYXf7h0pzMGo6sjXrjrx4fd_VM1sgYWGvaJY-kfpsQ4_Ioxlmv6um1u_v3wBbqRa-0</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Seroprevalence and trends in transfusion transmissible infections among voluntary non-remunerated blood donors at the Malawi Blood Transfusion Service-a time trend study</title><source>DOAJ Directory of Open Access Journals</source><source>Bioline International</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>M'baya, Bridon ; Jumbe, Vincent ; Samuel, Vincent ; M'bwana, Robert ; Mangani, Charles</creator><creatorcontrib>M'baya, Bridon ; Jumbe, Vincent ; Samuel, Vincent ; M'bwana, Robert ; Mangani, Charles</creatorcontrib><description>Introduction Collecting blood from voluntary non-remunerated blood
donors from low risk populations is a key strategy for blood safety.
Identifying such populations involves analysis of population and blood
donor data to identify risk factors for transfusion transmissible
infections (TTIs). There are no recent seroprevalence statistics for
blood donors in Malawi. This study fills this gap by describing
characteristics of blood donors, trend of annual prevalence of HIV,
HBV, HCV and syphilis and factors associated with each TTI. Methods
Retrospective analysis of blood donors' records in the MBTS
database from 2011 to 2015 was undertaken. Summary statistics were
performed to describe characteristics of the blood donors. Univariable
and multivariable logistic regression analyses were performed to
determine association between prevalence of infections and
socio-demographic factors. Time trend analysis was done to assess
changes in prevalence. P-value <0.05 was considered statistically
significant. Results The number of blood donors screened over the 5
year period was 125,893. The mean number of donors donating blood per
year was 39, 289; median age was 19 years; 82% were male, 87% single
and 72% students and56% were repeat blood donors. Overall prevalence of
each TTI decreased. The 2015 prevalence was: 3.6% for HBV; 1.9% for
HIV; 2.6% for Syphilis and 1.0% for HCV while the 2011 prevalence was
4.7% for HBV; 3.5% for HIV 3.2% for syphilis and 2.4% for HCV. Repeat
blood donors had significantly lower prevalence of TTIs than first time
donors. Females were associated with lower risk for HBV, HCV and
syphilis. Age ≥25 years and being out of school were associated
with HIV. Age ≥25 years was associated with reduced risk for HCV
and being self-employed and married were each associated with syphilis.
Conclusion The typical blood donor is a young single male student.
Repeat blood donation improves safety of the blood supply. .</description><identifier>ISSN: 1995-7262</identifier><language>eng</language><publisher>College of Medicine, University of Malawi and Medical Association of Malawi</publisher><subject>family replacement blood donors (FRBDs) ; Hepatitis B (HBV) ; Hepatitis C (HCV) ; HIV ; Syphilis ; Transfusion transmissible infections (TTIS) ; voluntary non remunerated blood donors (VNRBDs)</subject><ispartof>Malawi medical journal, 2020-09, Vol.31 (2)</ispartof><rights>Copyright 2019 - The College of Medicine and the Medical Association of Malawi</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,79426</link.rule.ids></links><search><creatorcontrib>M'baya, Bridon</creatorcontrib><creatorcontrib>Jumbe, Vincent</creatorcontrib><creatorcontrib>Samuel, Vincent</creatorcontrib><creatorcontrib>M'bwana, Robert</creatorcontrib><creatorcontrib>Mangani, Charles</creatorcontrib><title>Seroprevalence and trends in transfusion transmissible infections among voluntary non-remunerated blood donors at the Malawi Blood Transfusion Service-a time trend study</title><title>Malawi medical journal</title><description>Introduction Collecting blood from voluntary non-remunerated blood
donors from low risk populations is a key strategy for blood safety.
Identifying such populations involves analysis of population and blood
donor data to identify risk factors for transfusion transmissible
infections (TTIs). There are no recent seroprevalence statistics for
blood donors in Malawi. This study fills this gap by describing
characteristics of blood donors, trend of annual prevalence of HIV,
HBV, HCV and syphilis and factors associated with each TTI. Methods
Retrospective analysis of blood donors' records in the MBTS
database from 2011 to 2015 was undertaken. Summary statistics were
performed to describe characteristics of the blood donors. Univariable
and multivariable logistic regression analyses were performed to
determine association between prevalence of infections and
socio-demographic factors. Time trend analysis was done to assess
changes in prevalence. P-value <0.05 was considered statistically
significant. Results The number of blood donors screened over the 5
year period was 125,893. The mean number of donors donating blood per
year was 39, 289; median age was 19 years; 82% were male, 87% single
and 72% students and56% were repeat blood donors. Overall prevalence of
each TTI decreased. The 2015 prevalence was: 3.6% for HBV; 1.9% for
HIV; 2.6% for Syphilis and 1.0% for HCV while the 2011 prevalence was
4.7% for HBV; 3.5% for HIV 3.2% for syphilis and 2.4% for HCV. Repeat
blood donors had significantly lower prevalence of TTIs than first time
donors. Females were associated with lower risk for HBV, HCV and
syphilis. Age ≥25 years and being out of school were associated
with HIV. Age ≥25 years was associated with reduced risk for HCV
and being self-employed and married were each associated with syphilis.
Conclusion The typical blood donor is a young single male student.
Repeat blood donation improves safety of the blood supply. .</description><subject>family replacement blood donors (FRBDs)</subject><subject>Hepatitis B (HBV)</subject><subject>Hepatitis C (HCV)</subject><subject>HIV</subject><subject>Syphilis</subject><subject>Transfusion transmissible infections (TTIS)</subject><subject>voluntary non remunerated blood donors (VNRBDs)</subject><issn>1995-7262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNqVTstKxEAQnIOC6-Mf-gciSSQuuSqKF0_uPXQyHW2Z6V6mJ5H9JP_SQVfwKjRUUVVN1YnbNH3fVdv2tj1z52bvdd319bbbuM8XSrpPtGIgmQhQPORE4g1YCkOxeTHWI49sxmOgYs405aIbYFR5hVXDIhnTAUSlShQXoYSZPIxB1YNX0VTCGfIbwTMG_GC4-7Z2f1rKnJUnqhAyR_qZApYXf7h0pzMGo6sjXrjrx4fd_VM1sgYWGvaJY-kfpsQ4_Ioxlmv6um1u_v3wBbqRa-0</recordid><startdate>20200922</startdate><enddate>20200922</enddate><creator>M'baya, Bridon</creator><creator>Jumbe, Vincent</creator><creator>Samuel, Vincent</creator><creator>M'bwana, Robert</creator><creator>Mangani, Charles</creator><general>College of Medicine, University of Malawi and Medical Association of Malawi</general><scope>RBI</scope></search><sort><creationdate>20200922</creationdate><title>Seroprevalence and trends in transfusion transmissible infections among voluntary non-remunerated blood donors at the Malawi Blood Transfusion Service-a time trend study</title><author>M'baya, Bridon ; Jumbe, Vincent ; Samuel, Vincent ; M'bwana, Robert ; Mangani, Charles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-bioline_primary_cria_bioline_mm_mm190213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>family replacement blood donors (FRBDs)</topic><topic>Hepatitis B (HBV)</topic><topic>Hepatitis C (HCV)</topic><topic>HIV</topic><topic>Syphilis</topic><topic>Transfusion transmissible infections (TTIS)</topic><topic>voluntary non remunerated blood donors (VNRBDs)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>M'baya, Bridon</creatorcontrib><creatorcontrib>Jumbe, Vincent</creatorcontrib><creatorcontrib>Samuel, Vincent</creatorcontrib><creatorcontrib>M'bwana, Robert</creatorcontrib><creatorcontrib>Mangani, Charles</creatorcontrib><collection>Bioline International</collection><jtitle>Malawi medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>M'baya, Bridon</au><au>Jumbe, Vincent</au><au>Samuel, Vincent</au><au>M'bwana, Robert</au><au>Mangani, Charles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seroprevalence and trends in transfusion transmissible infections among voluntary non-remunerated blood donors at the Malawi Blood Transfusion Service-a time trend study</atitle><jtitle>Malawi medical journal</jtitle><date>2020-09-22</date><risdate>2020</risdate><volume>31</volume><issue>2</issue><issn>1995-7262</issn><abstract>Introduction Collecting blood from voluntary non-remunerated blood
donors from low risk populations is a key strategy for blood safety.
Identifying such populations involves analysis of population and blood
donor data to identify risk factors for transfusion transmissible
infections (TTIs). There are no recent seroprevalence statistics for
blood donors in Malawi. This study fills this gap by describing
characteristics of blood donors, trend of annual prevalence of HIV,
HBV, HCV and syphilis and factors associated with each TTI. Methods
Retrospective analysis of blood donors' records in the MBTS
database from 2011 to 2015 was undertaken. Summary statistics were
performed to describe characteristics of the blood donors. Univariable
and multivariable logistic regression analyses were performed to
determine association between prevalence of infections and
socio-demographic factors. Time trend analysis was done to assess
changes in prevalence. P-value <0.05 was considered statistically
significant. Results The number of blood donors screened over the 5
year period was 125,893. The mean number of donors donating blood per
year was 39, 289; median age was 19 years; 82% were male, 87% single
and 72% students and56% were repeat blood donors. Overall prevalence of
each TTI decreased. The 2015 prevalence was: 3.6% for HBV; 1.9% for
HIV; 2.6% for Syphilis and 1.0% for HCV while the 2011 prevalence was
4.7% for HBV; 3.5% for HIV 3.2% for syphilis and 2.4% for HCV. Repeat
blood donors had significantly lower prevalence of TTIs than first time
donors. Females were associated with lower risk for HBV, HCV and
syphilis. Age ≥25 years and being out of school were associated
with HIV. Age ≥25 years was associated with reduced risk for HCV
and being self-employed and married were each associated with syphilis.
Conclusion The typical blood donor is a young single male student.
Repeat blood donation improves safety of the blood supply. .</abstract><pub>College of Medicine, University of Malawi and Medical Association of Malawi</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1995-7262 |
| ispartof | Malawi medical journal, 2020-09, Vol.31 (2) |
| issn | 1995-7262 |
| language | eng |
| recordid | cdi_bioline_primary_cria_bioline_mm_mm19021 |
| source | DOAJ Directory of Open Access Journals; Bioline International; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | family replacement blood donors (FRBDs) Hepatitis B (HBV) Hepatitis C (HCV) HIV Syphilis Transfusion transmissible infections (TTIS) voluntary non remunerated blood donors (VNRBDs) |
| title | Seroprevalence and trends in transfusion transmissible infections among voluntary non-remunerated blood donors at the Malawi Blood Transfusion Service-a time trend study |
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