Effect of Methanolic Extract of Chrysophyllum albidum Bark on Hematological Indices in Mice with Experimental Hemorrhagic Anemia
Chrysophyllum albidum is a common plant in the tropical Central, East and West Africa region.Its fruits are widely consumed and plant parts are vastly utilized. The broad utilization and consumption of this plant parts make it pertinent to examine its effect on blood parameters. This study was there...
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| Veröffentlicht in: | African journal of biomedical research 2013-03, Vol.15 (2) |
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| creator | Adewoye, E.O Salami, A.T Emikpe, B.O |
| description | Chrysophyllum albidum is a common plant in the tropical Central, East
and West Africa region.Its fruits are widely consumed and plant parts
are vastly utilized. The broad utilization and consumption of this
plant parts make it pertinent to examine its effect on blood
parameters. This study was therefore designed to investigate the effect
of methanolic extract of Chrysophyllum albidum on haematological
indices in mice. Seventy five Swiss albino male mice (19g - 22g)
were used for this study. 45 of which were anaesthetized with diethyl
ether and 0.25mls (40%) of their blood drained through the
retro-orbital plexus. Haemoglobin concentration (Hb) was determined
24hours after. Animals with Hb of |
| format | Article |
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and West Africa region.Its fruits are widely consumed and plant parts
are vastly utilized. The broad utilization and consumption of this
plant parts make it pertinent to examine its effect on blood
parameters. This study was therefore designed to investigate the effect
of methanolic extract of Chrysophyllum albidum on haematological
indices in mice. Seventy five Swiss albino male mice (19g - 22g)
were used for this study. 45 of which were anaesthetized with diethyl
ether and 0.25mls (40%) of their blood drained through the
retro-orbital plexus. Haemoglobin concentration (Hb) was determined
24hours after. Animals with Hb of <11.12 g/dl were considered
anaemic and randomly divided into five groups of fifteen animals.
Group1 - control animals (Nor), Group 2 - animals treated with
1000mg/kg b.w of Chrysophyllum albidumalone (MeCaB), Group 3- animals
bled and treated with ferrous sulphate (BHaem), Group 4 - animals bled
and treated with MeCaB (BMeCaB) and Group 5 animals were bled and
untreated (Bla). Complete blood count was done using standard methods
on days 3 and 7.The body weight of BMeCaB group showed significant
(p<0.05) increase compared with control and Bla. The BMeCaB group
showed significant increase (p<0.05) in RBC and Packed Cell Volume
within 48 hours of treatment and up to day 7 compared with Bla and
BHaem. There was significant decrease (p<0.05) in the Neutrophil
lymphocyte ratio of BMeCaB and MeCaB compared with Bla.This study
established the haematinic potentials of Chrysophyllum albidum</description><identifier>ISSN: 1119-5096</identifier><language>eng</language><publisher>Ibadan Biomedical Communications Group</publisher><subject>Chrysophyllum albidum, blood cells, anemia, Mice</subject><ispartof>African journal of biomedical research, 2013-03, Vol.15 (2)</ispartof><rights>Copyright 2012 - Ibadan Biomedical Communications Group</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,79426</link.rule.ids></links><search><creatorcontrib>Adewoye, E.O</creatorcontrib><creatorcontrib>Salami, A.T</creatorcontrib><creatorcontrib>Emikpe, B.O</creatorcontrib><title>Effect of Methanolic Extract of Chrysophyllum albidum Bark on Hematological Indices in Mice with Experimental Hemorrhagic Anemia</title><title>African journal of biomedical research</title><description>Chrysophyllum albidum is a common plant in the tropical Central, East
and West Africa region.Its fruits are widely consumed and plant parts
are vastly utilized. The broad utilization and consumption of this
plant parts make it pertinent to examine its effect on blood
parameters. This study was therefore designed to investigate the effect
of methanolic extract of Chrysophyllum albidum on haematological
indices in mice. Seventy five Swiss albino male mice (19g - 22g)
were used for this study. 45 of which were anaesthetized with diethyl
ether and 0.25mls (40%) of their blood drained through the
retro-orbital plexus. Haemoglobin concentration (Hb) was determined
24hours after. Animals with Hb of <11.12 g/dl were considered
anaemic and randomly divided into five groups of fifteen animals.
Group1 - control animals (Nor), Group 2 - animals treated with
1000mg/kg b.w of Chrysophyllum albidumalone (MeCaB), Group 3- animals
bled and treated with ferrous sulphate (BHaem), Group 4 - animals bled
and treated with MeCaB (BMeCaB) and Group 5 animals were bled and
untreated (Bla). Complete blood count was done using standard methods
on days 3 and 7.The body weight of BMeCaB group showed significant
(p<0.05) increase compared with control and Bla. The BMeCaB group
showed significant increase (p<0.05) in RBC and Packed Cell Volume
within 48 hours of treatment and up to day 7 compared with Bla and
BHaem. There was significant decrease (p<0.05) in the Neutrophil
lymphocyte ratio of BMeCaB and MeCaB compared with Bla.This study
established the haematinic potentials of Chrysophyllum albidum</description><subject>Chrysophyllum albidum, blood cells, anemia, Mice</subject><issn>1119-5096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNqVjs1qAkEQhOeQgCbxHfoFlB2zih6NbDAHb7kv7Wyv0zo_y8xIsrc8ehqSPECgoIriq6bv1FRrvZ2vqu16oh5yvlRVva6Xm6n6avqeTIHYw5GKxRAdG2g-S8Kfdm_TmONgR-duHtCduBN_wXSFGOBAHkt08cwGHbyFjg1l4ABHCfDBxcqtgRJ7CkUI4WNKFoWHXSDP-KTue3SZZr_-qBavzfv-MD-xvBKoHWSMaWxNYmz_St-J9LLS9fO_B99BN1pk</recordid><startdate>20130313</startdate><enddate>20130313</enddate><creator>Adewoye, E.O</creator><creator>Salami, A.T</creator><creator>Emikpe, B.O</creator><general>Ibadan Biomedical Communications Group</general><scope>RBI</scope></search><sort><creationdate>20130313</creationdate><title>Effect of Methanolic Extract of Chrysophyllum albidum Bark on Hematological Indices in Mice with Experimental Hemorrhagic Anemia</title><author>Adewoye, E.O ; Salami, A.T ; Emikpe, B.O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-bioline_primary_cria_bioline_md_md120143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Chrysophyllum albidum, blood cells, anemia, Mice</topic><toplevel>online_resources</toplevel><creatorcontrib>Adewoye, E.O</creatorcontrib><creatorcontrib>Salami, A.T</creatorcontrib><creatorcontrib>Emikpe, B.O</creatorcontrib><collection>Bioline International</collection><jtitle>African journal of biomedical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adewoye, E.O</au><au>Salami, A.T</au><au>Emikpe, B.O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Methanolic Extract of Chrysophyllum albidum Bark on Hematological Indices in Mice with Experimental Hemorrhagic Anemia</atitle><jtitle>African journal of biomedical research</jtitle><date>2013-03-13</date><risdate>2013</risdate><volume>15</volume><issue>2</issue><issn>1119-5096</issn><abstract>Chrysophyllum albidum is a common plant in the tropical Central, East
and West Africa region.Its fruits are widely consumed and plant parts
are vastly utilized. The broad utilization and consumption of this
plant parts make it pertinent to examine its effect on blood
parameters. This study was therefore designed to investigate the effect
of methanolic extract of Chrysophyllum albidum on haematological
indices in mice. Seventy five Swiss albino male mice (19g - 22g)
were used for this study. 45 of which were anaesthetized with diethyl
ether and 0.25mls (40%) of their blood drained through the
retro-orbital plexus. Haemoglobin concentration (Hb) was determined
24hours after. Animals with Hb of <11.12 g/dl were considered
anaemic and randomly divided into five groups of fifteen animals.
Group1 - control animals (Nor), Group 2 - animals treated with
1000mg/kg b.w of Chrysophyllum albidumalone (MeCaB), Group 3- animals
bled and treated with ferrous sulphate (BHaem), Group 4 - animals bled
and treated with MeCaB (BMeCaB) and Group 5 animals were bled and
untreated (Bla). Complete blood count was done using standard methods
on days 3 and 7.The body weight of BMeCaB group showed significant
(p<0.05) increase compared with control and Bla. The BMeCaB group
showed significant increase (p<0.05) in RBC and Packed Cell Volume
within 48 hours of treatment and up to day 7 compared with Bla and
BHaem. There was significant decrease (p<0.05) in the Neutrophil
lymphocyte ratio of BMeCaB and MeCaB compared with Bla.This study
established the haematinic potentials of Chrysophyllum albidum</abstract><pub>Ibadan Biomedical Communications Group</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1119-5096 |
| ispartof | African journal of biomedical research, 2013-03, Vol.15 (2) |
| issn | 1119-5096 |
| language | eng |
| recordid | cdi_bioline_primary_cria_bioline_md_md12014 |
| source | African Journals Online (Open Access); Bioline International; EZB-FREE-00999 freely available EZB journals |
| subjects | Chrysophyllum albidum, blood cells, anemia, Mice |
| title | Effect of Methanolic Extract of Chrysophyllum albidum Bark on Hematological Indices in Mice with Experimental Hemorrhagic Anemia |
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