Case Report - Penicillamine induced pseudoxanthoma elasticum with elastosis perforans serpiginosa
Long term D-penicillamine therapy, especially when used to treat Wilson′s disease has been shown to cause elastosis perforans serpiginosa, pseudoxanthoma elasticum perforans and other degenerative dermatoses. We report a 23-year-old male patient who presented with multiple firm papules, nodules over...
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| Veröffentlicht in: | Indian journal of dermatology, venereology, and leprology venereology, and leprology, 2005-12, Vol.71 (3) |
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| container_title | Indian journal of dermatology, venereology, and leprology |
| container_volume | 71 |
| creator | Rath Namita, Bhardwaj Amit, Kar HemantKumar, Sharma P.K., Bharadwaj Meenakhshi, Bharija S.C |
| description | Long term D-penicillamine therapy, especially when used to treat
Wilson′s disease has been shown to cause elastosis perforans
serpiginosa, pseudoxanthoma elasticum perforans and other degenerative
dermatoses. We report a 23-year-old male patient who presented with
multiple firm papules, nodules over the neck, axillae, front of elbows
for five years. He was a known case of Wilson′s disease on
long-term treatment with penicillamine for the past 12 years. The
papulonodular lesions were non-tender and some were discrete while
others were arranged in a circinate pattern. There was central scarring
of the skin within the circinate lesions. In addition, there were
several small yellowish papules on both sides of the neck which
eventually became confluent to form plaques. Histopathology confirmed
the diagnosis of elastosis perforans serpiginosa and pseudoxanthoma
elasticum. He was treated with cryotherapy (using liquid nitrogen
through cryojet) for former lesions. The lesions showed remarkable
improvement after five sittings. Now the patient is under trientine
hydrochloride (750 mg twice daily) for Wilson′s disease. |
| format | Article |
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Wilson′s disease has been shown to cause elastosis perforans
serpiginosa, pseudoxanthoma elasticum perforans and other degenerative
dermatoses. We report a 23-year-old male patient who presented with
multiple firm papules, nodules over the neck, axillae, front of elbows
for five years. He was a known case of Wilson′s disease on
long-term treatment with penicillamine for the past 12 years. The
papulonodular lesions were non-tender and some were discrete while
others were arranged in a circinate pattern. There was central scarring
of the skin within the circinate lesions. In addition, there were
several small yellowish papules on both sides of the neck which
eventually became confluent to form plaques. Histopathology confirmed
the diagnosis of elastosis perforans serpiginosa and pseudoxanthoma
elasticum. He was treated with cryotherapy (using liquid nitrogen
through cryojet) for former lesions. The lesions showed remarkable
improvement after five sittings. Now the patient is under trientine
hydrochloride (750 mg twice daily) for Wilson′s disease.</description><identifier>ISSN: 0378-6323</identifier><language>eng</language><publisher>Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)</publisher><subject>Penicillamine, Elastosis perforans serpiginosa, Pseudoxanthoma elasticum</subject><ispartof>Indian journal of dermatology, venereology, and leprology, 2005-12, Vol.71 (3)</ispartof><rights>Copyright 2005 Indian Journal of Dermatology, Venereology and Leprology.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,79426</link.rule.ids></links><search><creatorcontrib>Rath Namita, Bhardwaj Amit, Kar HemantKumar, Sharma P.K., Bharadwaj Meenakhshi, Bharija S.C</creatorcontrib><title>Case Report - Penicillamine induced pseudoxanthoma elasticum with elastosis perforans serpiginosa</title><title>Indian journal of dermatology, venereology, and leprology</title><description>Long term D-penicillamine therapy, especially when used to treat
Wilson′s disease has been shown to cause elastosis perforans
serpiginosa, pseudoxanthoma elasticum perforans and other degenerative
dermatoses. We report a 23-year-old male patient who presented with
multiple firm papules, nodules over the neck, axillae, front of elbows
for five years. He was a known case of Wilson′s disease on
long-term treatment with penicillamine for the past 12 years. The
papulonodular lesions were non-tender and some were discrete while
others were arranged in a circinate pattern. There was central scarring
of the skin within the circinate lesions. In addition, there were
several small yellowish papules on both sides of the neck which
eventually became confluent to form plaques. Histopathology confirmed
the diagnosis of elastosis perforans serpiginosa and pseudoxanthoma
elasticum. He was treated with cryotherapy (using liquid nitrogen
through cryojet) for former lesions. The lesions showed remarkable
improvement after five sittings. Now the patient is under trientine
hydrochloride (750 mg twice daily) for Wilson′s disease.</description><subject>Penicillamine, Elastosis perforans serpiginosa, Pseudoxanthoma elasticum</subject><issn>0378-6323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><recordid>eNqVjUsKwkAQRGeh4PcOfYHI6BjNPiguRdyHNuloy2RmmE783F5BPYBQULyCR_XUUJt1lqzMwgzUSOSq9WK5MvOhwhyF4EDBxxYS2JPjkq3Fhh0Bu6orqYIg1FX-ga69-AaBLErLZdfAndvLB72wQKBY-4hOQCgGPrPzghPVr9EKTb89VrPt5pjvkhN7-34pQuQG47MoI2PxG6vbOzrVaWb-Fl4haVBv</recordid><startdate>20051231</startdate><enddate>20051231</enddate><creator>Rath Namita, Bhardwaj Amit, Kar HemantKumar, Sharma P.K., Bharadwaj Meenakhshi, Bharija S.C</creator><general>Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)</general><scope>RBI</scope></search><sort><creationdate>20051231</creationdate><title>Case Report - Penicillamine induced pseudoxanthoma elasticum with elastosis perforans serpiginosa</title><author>Rath Namita, Bhardwaj Amit, Kar HemantKumar, Sharma P.K., Bharadwaj Meenakhshi, Bharija S.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-bioline_primary_cria_bioline_dv_dv050583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Penicillamine, Elastosis perforans serpiginosa, Pseudoxanthoma elasticum</topic><toplevel>online_resources</toplevel><creatorcontrib>Rath Namita, Bhardwaj Amit, Kar HemantKumar, Sharma P.K., Bharadwaj Meenakhshi, Bharija S.C</creatorcontrib><collection>Bioline International</collection><jtitle>Indian journal of dermatology, venereology, and leprology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rath Namita, Bhardwaj Amit, Kar HemantKumar, Sharma P.K., Bharadwaj Meenakhshi, Bharija S.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Case Report - Penicillamine induced pseudoxanthoma elasticum with elastosis perforans serpiginosa</atitle><jtitle>Indian journal of dermatology, venereology, and leprology</jtitle><date>2005-12-31</date><risdate>2005</risdate><volume>71</volume><issue>3</issue><issn>0378-6323</issn><abstract>Long term D-penicillamine therapy, especially when used to treat
Wilson′s disease has been shown to cause elastosis perforans
serpiginosa, pseudoxanthoma elasticum perforans and other degenerative
dermatoses. We report a 23-year-old male patient who presented with
multiple firm papules, nodules over the neck, axillae, front of elbows
for five years. He was a known case of Wilson′s disease on
long-term treatment with penicillamine for the past 12 years. The
papulonodular lesions were non-tender and some were discrete while
others were arranged in a circinate pattern. There was central scarring
of the skin within the circinate lesions. In addition, there were
several small yellowish papules on both sides of the neck which
eventually became confluent to form plaques. Histopathology confirmed
the diagnosis of elastosis perforans serpiginosa and pseudoxanthoma
elasticum. He was treated with cryotherapy (using liquid nitrogen
through cryojet) for former lesions. The lesions showed remarkable
improvement after five sittings. Now the patient is under trientine
hydrochloride (750 mg twice daily) for Wilson′s disease.</abstract><pub>Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL)</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-6323 |
| ispartof | Indian journal of dermatology, venereology, and leprology, 2005-12, Vol.71 (3) |
| issn | 0378-6323 |
| language | eng |
| recordid | cdi_bioline_primary_cria_bioline_dv_dv05058 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Bioline International |
| subjects | Penicillamine, Elastosis perforans serpiginosa, Pseudoxanthoma elasticum |
| title | Case Report - Penicillamine induced pseudoxanthoma elasticum with elastosis perforans serpiginosa |
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