Genomic Analysis Reveals a Point Mutation in the Two-Component Sensor Gene graS That Leads to Intermediate Vancomycin Resistance in Clinical Staphylococcus aureus
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Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2008-10, Vol.52 (10), p.3755-3762 |
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creator | HOWDEN, Benjamin P STINEAR, Timothy P ALLEN, David L JOHNSON, Paul D. R WARD, Peter B DAVIES, John K |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.01613-07</identifier><identifier>PMID: 18644967</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Amino Acid Sequence ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial diseases ; Base Sequence ; Biological and medical sciences ; DNA Primers - genetics ; DNA, Bacterial - genetics ; Genes, Bacterial ; Genomics ; Human bacterial diseases ; Humans ; Infectious diseases ; Mechanisms of Resistance ; Medical sciences ; Molecular Sequence Data ; Pharmacology. Drug treatments ; Point Mutation ; Sequence Homology, Amino Acid ; Sequence Homology, Nucleic Acid ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - microbiology ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - genetics ; Vancomycin Resistance ; Vancomycin Resistance - genetics</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2008-10, Vol.52 (10), p.3755-3762</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright © 2008 American Society for Microbiology</rights><rights>Copyright © 2008, American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a504t-f060b4592f0ad61a0ebadb208baf61c73cef1c78d0d3609c193b43cc15ff9ef73</citedby><cites>FETCH-LOGICAL-a504t-f060b4592f0ad61a0ebadb208baf61c73cef1c78d0d3609c193b43cc15ff9ef73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565880/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565880/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20687001$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18644967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HOWDEN, Benjamin P</creatorcontrib><creatorcontrib>STINEAR, Timothy P</creatorcontrib><creatorcontrib>ALLEN, David L</creatorcontrib><creatorcontrib>JOHNSON, Paul D. R</creatorcontrib><creatorcontrib>WARD, Peter B</creatorcontrib><creatorcontrib>DAVIES, John K</creatorcontrib><title>Genomic Analysis Reveals a Point Mutation in the Two-Component Sensor Gene graS That Leads to Intermediate Vancomycin Resistance in Clinical Staphylococcus aureus</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>AAC</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>Amino Acid Sequence</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial diseases</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>DNA Primers - genetics</subject><subject>DNA, Bacterial - genetics</subject><subject>Genes, Bacterial</subject><subject>Genomics</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Mechanisms of Resistance</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Pharmacology. Drug treatments</subject><subject>Point Mutation</subject><subject>Sequence Homology, Amino Acid</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - genetics</subject><subject>Vancomycin Resistance</subject><subject>Vancomycin Resistance - genetics</subject><issn>0066-4804</issn><issn>1098-6596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9rFEEQxQdRzBq9eZZGUBCcWD1_emcuwrJoDESU7Oq1qemp2ekw073p7knYr-Mntdddoh7EU1HUj1eveJUkzzmccZ5V7xaL5RlwwfMU5g-SGYe6SkVZi4fJDECItKigOEmeeH8NsS9reJyc8EoURS3ms-THORk7asUWBoed155d0S3h4Bmyr1abwD5PAYO2hmnDQk9sfWfTpR231lCcrsh461hUIbZxuGLrHgO7JGw9C5ZdmEBupFZjIPYdjbLjTkWhK4qrQuxpL7sctNEKB7YKuO13g1VWqSlamBxN_mnyqIuG6NmxnibfPn5YLz-ll1_OL5aLyxRLKELagYCmKOusA2wFR6AG2yaDqsFOcDXPFXWxVC20uYBa8TpvilwpXnZdTd08P03eH3S3UxMtq3iew0FunR7R7aRFLf-eGN3Ljb2VWSnKqoIo8Poo4OzNRD7IUXtFw4CG7OSlqAXkRVb_F8x4UYOoRATfHkDlrPeOuns3HOQ-fRnTl7_Sl7C_4M0BRz9m8tpOLobq_8W--PPa38LH14jAqyOAPmbTuZiW9vdcFg3OAXjkXh64Xm_6O-1Ixu0SUcky26_O52WZ_wQxj9NX</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>HOWDEN, Benjamin P</creator><creator>STINEAR, Timothy P</creator><creator>ALLEN, David L</creator><creator>JOHNSON, Paul D. 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Drug treatments</topic><topic>Point Mutation</topic><topic>Sequence Homology, Amino Acid</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - genetics</topic><topic>Vancomycin Resistance</topic><topic>Vancomycin Resistance - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOWDEN, Benjamin P</creatorcontrib><creatorcontrib>STINEAR, Timothy P</creatorcontrib><creatorcontrib>ALLEN, David L</creatorcontrib><creatorcontrib>JOHNSON, Paul D. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>18644967</pmid><doi>10.1128/AAC.01613-07</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
subjects | Amino Acid Sequence Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial diseases Base Sequence Biological and medical sciences DNA Primers - genetics DNA, Bacterial - genetics Genes, Bacterial Genomics Human bacterial diseases Humans Infectious diseases Mechanisms of Resistance Medical sciences Molecular Sequence Data Pharmacology. Drug treatments Point Mutation Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - genetics Vancomycin Resistance Vancomycin Resistance - genetics |
title | Genomic Analysis Reveals a Point Mutation in the Two-Component Sensor Gene graS That Leads to Intermediate Vancomycin Resistance in Clinical Staphylococcus aureus |
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