Entecavir for Treatment of Hepatitis B Virus Displays No In Vitro Mitochondrial Toxicity or DNA Polymerase Gamma Inhibition

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2008-02, Vol.52 (2), p.598-605
Hauptverfasser:	MAZZUCCO, Charles E, HAMATAKE, Robert K, COLONNO, Richard J, TENNEY, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Antiviral Agents - adverse effects Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Biological and medical sciences DNA Polymerase gamma DNA, Mitochondrial - drug effects DNA-Directed DNA Polymerase Electron Transport Complex II - drug effects Electron Transport Complex II - metabolism Electron Transport Complex IV - drug effects Electron Transport Complex IV - metabolism Guanine Guanine - adverse effects Guanine - analogs & derivatives Guanine - pharmacology Guanine - therapeutic use Hepatitis B - drug therapy Hepatitis B - virology Hepatitis B virus Hepatitis B virus - drug effects Human viral diseases Humans Infectious diseases Medical sciences Mitochondria Mitochondria - drug effects Mitochondria - enzymology Mitochondria - metabolism Nucleic Acid Synthesis Inhibitors Pharmacology. Drug treatments Reverse Transcriptase Inhibitors Reverse Transcriptase Inhibitors - adverse effects Reverse Transcriptase Inhibitors - pharmacology Reverse Transcriptase Inhibitors - therapeutic use Tumor Cells, Cultured Viral diseases Viral hepatitis
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