Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 2008-08, Vol.52 (8), p.2861-2869 |
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| creator | HOMBROUCK, Anneleen VAN REMOORTEL, Barbara LETIZIA BARRECA, Maria DE LUCA, Laura FERRO, Stefania CHIMIRRI, Alba DEBYSER, Zeger WITVROUW, Myriam MICHIELS, Martine NOPPE, Wim CHRIST, Frauke ENEROTH, Anders SAHLBERG, Britt Louise BENKESTOCK, Kurt VRANG, Lotta GUNNAR JOHANSSON, Nils |
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| doi_str_mv | 10.1128/AAC.00210-08 |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.00210-08</identifier><identifier>PMID: 18541726</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Anti-HIV Agents - chemical synthesis ; Anti-HIV Agents - chemistry ; Anti-HIV Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral Agents ; Biological and medical sciences ; Caco-2 Cells ; Cell Line, Tumor ; Drug Evaluation, Preclinical ; Enzyme-Linked Immunosorbent Assay ; HIV ; HIV - drug effects ; HIV - enzymology ; HIV - genetics ; HIV Integrase Inhibitors ; HIV Integrase Inhibitors - chemical synthesis ; HIV Integrase Inhibitors - chemistry ; HIV Integrase Inhibitors - pharmacology ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Indoles ; Indoles - chemical synthesis ; Indoles - chemistry ; Indoles - pharmacology ; Infectious diseases ; Integrases ; Integrases - genetics ; Integrases - metabolism ; Medical sciences ; Molecular Structure ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Proteins - metabolism ; Virus Replication - drug effects</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2008-08, Vol.52 (8), p.2861-2869</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright © 2008 American Society for Microbiology</rights><rights>Copyright © 2008, American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a472t-5509d6ac291b9180eb39f4606c231bbabced92c11e8500b8ff4c8f176f7e732b3</citedby><cites>FETCH-LOGICAL-a472t-5509d6ac291b9180eb39f4606c231bbabced92c11e8500b8ff4c8f176f7e732b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493095/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493095/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20573420$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18541726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HOMBROUCK, Anneleen</creatorcontrib><creatorcontrib>VAN REMOORTEL, Barbara</creatorcontrib><creatorcontrib>LETIZIA BARRECA, Maria</creatorcontrib><creatorcontrib>DE LUCA, Laura</creatorcontrib><creatorcontrib>FERRO, Stefania</creatorcontrib><creatorcontrib>CHIMIRRI, Alba</creatorcontrib><creatorcontrib>DEBYSER, Zeger</creatorcontrib><creatorcontrib>WITVROUW, Myriam</creatorcontrib><creatorcontrib>MICHIELS, Martine</creatorcontrib><creatorcontrib>NOPPE, Wim</creatorcontrib><creatorcontrib>CHRIST, Frauke</creatorcontrib><creatorcontrib>ENEROTH, Anders</creatorcontrib><creatorcontrib>SAHLBERG, Britt Louise</creatorcontrib><creatorcontrib>BENKESTOCK, Kurt</creatorcontrib><creatorcontrib>VRANG, Lotta</creatorcontrib><creatorcontrib>GUNNAR JOHANSSON, Nils</creatorcontrib><title>Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>AAC</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>Anti-HIV Agents - chemical synthesis</subject><subject>Anti-HIV Agents - chemistry</subject><subject>Anti-HIV Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral Agents</subject><subject>Biological and medical sciences</subject><subject>Caco-2 Cells</subject><subject>Cell Line, Tumor</subject><subject>Drug Evaluation, Preclinical</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>HIV</subject><subject>HIV - drug effects</subject><subject>HIV - enzymology</subject><subject>HIV - genetics</subject><subject>HIV Integrase Inhibitors</subject><subject>HIV Integrase Inhibitors - chemical synthesis</subject><subject>HIV Integrase Inhibitors - chemistry</subject><subject>HIV Integrase Inhibitors - pharmacology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. 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Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Indoles</topic><topic>Indoles - chemical synthesis</topic><topic>Indoles - chemistry</topic><topic>Indoles - pharmacology</topic><topic>Infectious diseases</topic><topic>Integrases</topic><topic>Integrases - genetics</topic><topic>Integrases - metabolism</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>18541726</pmid><doi>10.1128/AAC.00210-08</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2008-08, Vol.52 (8), p.2861-2869 |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_asm2_journals_10_1128_AAC_00210_08 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Biological and medical sciences Caco-2 Cells Cell Line, Tumor Drug Evaluation, Preclinical Enzyme-Linked Immunosorbent Assay HIV HIV - drug effects HIV - enzymology HIV - genetics HIV Integrase Inhibitors HIV Integrase Inhibitors - chemical synthesis HIV Integrase Inhibitors - chemistry HIV Integrase Inhibitors - pharmacology Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Indoles Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Infectious diseases Integrases Integrases - genetics Integrases - metabolism Medical sciences Molecular Structure Pharmacology. Drug treatments Polymerase Chain Reaction Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Proteins - metabolism Virus Replication - drug effects |
| title | Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors |
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