Insights into the L,D-Transpeptidases and D,D-Carboxypeptidase of Mycobacterium abscessus: Ceftaroline, Imipenem, and Novel Diazabicyclooctane Inhibitors

Mycobacterium abscessus is a highly drug-resistant nontuberculous mycobacterium (NTM). Efforts to discover new treatments for M. abscessus infections are accelerating, with a focus on cell wall synthesis proteins (M. abscessus L,D-transpeptidases 1 to 5 [Ldt(Mab1) to Ldt(Mab5)] and D,D-carboxypeptid...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2020-07, Vol.64 (8), Article 00098
Hauptverfasser:	Dousa, Khalid M., Kurz, Sebastian G., Taracila, Magdalena A., Bonfield, Tracey, Bethel, Christopher R., Barnes, Melissa D., Selvaraju, Suresh, Abdelhamed, Ayman M., Kreiswirth, Barry N., Boom, W. Henry, Kasperbauer, Shannon H., Daley, Charles L., Bonomo, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Azabicyclo Compounds - pharmacology beta-Lactamase Inhibitors Carboxypeptidases Ceftaroline Cephalosporins Imipenem - pharmacology Life Sciences & Biomedicine Mechanisms of Resistance Microbial Sensitivity Tests Microbiology Mycobacterium abscessus Peptidyl Transferases Pharmacology & Pharmacy Science & Technology
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