Evaluation of the Antibacterial and Wound Healing Properties of a Burn Ointment Containing Curcumin, Honey, and Potassium Aluminium
Burn wounds can severely trouble the health system and life quality of patients. The present study aimed to analyze the synergistic healing properties of curcumin, honey, and potassium alum substances merged in a newly-devised burn ointment on second-degree burn wounds in rats. The MIC and MBC tests...
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| creator | Shahbandeh, Mahsa Salehi, Mahsa Amin Soltanyzadeh, Maryam Mirzaei, Mehrnaz Maleki, Ali rad, Abdolkarim Chehregani Fatemi, Mohammad Javad Mirnejad, Reza Dahmardehei, Mostafa |
| description | Burn wounds can severely trouble the health system and life quality of
patients. The present study aimed to analyze the synergistic healing properties
of curcumin, honey, and potassium alum substances merged in a newly-devised
burn ointment on second-degree burn wounds in rats. The MIC and MBC tests on
200 clinical isolates of Pseudomonas aeruginous are compared to imipenem in
vitro. Their killing time and cytotoxicity are also studied using a standard
isolate of P. aeruginous, fibroblast stem cells (FSC) and mouse embryonic
fibroblasts (MEF). Furthermore, histopathological and histomorphological
assessments are conducted on 150 male Wistar rats whitin four experimental
groups to evaluate the efficiency of the prepared burn ointment. We found a
significant wound healing in both macroscopical observations and microscopical
evaluations. Both curcumin and honey show strong antimicrobial effects with no
cytotoxicity. Also, the histopathological results present a considerable and
comparable wound re-epithelization in the a group of rats treated with both
honey and curcumin after 7 days. The burn ointment containing curcumin, honey,
and potassium alum show considerable efficacy in accelerating the healing of
experimentally-induced burn wounds in animals. Th novel onement product is
propose as a powerful alternative for the topical treatment of burn injuries. |
| doi_str_mv | 10.48550/arxiv.2211.11939 |
| format | Article |
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patients. The present study aimed to analyze the synergistic healing properties
of curcumin, honey, and potassium alum substances merged in a newly-devised
burn ointment on second-degree burn wounds in rats. The MIC and MBC tests on
200 clinical isolates of Pseudomonas aeruginous are compared to imipenem in
vitro. Their killing time and cytotoxicity are also studied using a standard
isolate of P. aeruginous, fibroblast stem cells (FSC) and mouse embryonic
fibroblasts (MEF). Furthermore, histopathological and histomorphological
assessments are conducted on 150 male Wistar rats whitin four experimental
groups to evaluate the efficiency of the prepared burn ointment. We found a
significant wound healing in both macroscopical observations and microscopical
evaluations. Both curcumin and honey show strong antimicrobial effects with no
cytotoxicity. Also, the histopathological results present a considerable and
comparable wound re-epithelization in the a group of rats treated with both
honey and curcumin after 7 days. The burn ointment containing curcumin, honey,
and potassium alum show considerable efficacy in accelerating the healing of
experimentally-induced burn wounds in animals. Th novel onement product is
propose as a powerful alternative for the topical treatment of burn injuries.</description><identifier>DOI: 10.48550/arxiv.2211.11939</identifier><language>eng</language><subject>Quantitative Biology - Tissues and Organs</subject><creationdate>2022-11</creationdate><rights>http://arxiv.org/licenses/nonexclusive-distrib/1.0</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>228,230,780,885</link.rule.ids><linktorsrc>$$Uhttps://arxiv.org/abs/2211.11939$$EView_record_in_Cornell_University$$FView_record_in_$$GCornell_University$$Hfree_for_read</linktorsrc><backlink>$$Uhttps://doi.org/10.48550/arXiv.2211.11939$$DView paper in arXiv$$Hfree_for_read</backlink></links><search><creatorcontrib>Shahbandeh, Mahsa</creatorcontrib><creatorcontrib>Salehi, Mahsa Amin</creatorcontrib><creatorcontrib>Soltanyzadeh, Maryam</creatorcontrib><creatorcontrib>Mirzaei, Mehrnaz</creatorcontrib><creatorcontrib>Maleki, Ali</creatorcontrib><creatorcontrib>rad, Abdolkarim Chehregani</creatorcontrib><creatorcontrib>Fatemi, Mohammad Javad</creatorcontrib><creatorcontrib>Mirnejad, Reza</creatorcontrib><creatorcontrib>Dahmardehei, Mostafa</creatorcontrib><title>Evaluation of the Antibacterial and Wound Healing Properties of a Burn Ointment Containing Curcumin, Honey, and Potassium Aluminium</title><description>Burn wounds can severely trouble the health system and life quality of
patients. The present study aimed to analyze the synergistic healing properties
of curcumin, honey, and potassium alum substances merged in a newly-devised
burn ointment on second-degree burn wounds in rats. The MIC and MBC tests on
200 clinical isolates of Pseudomonas aeruginous are compared to imipenem in
vitro. Their killing time and cytotoxicity are also studied using a standard
isolate of P. aeruginous, fibroblast stem cells (FSC) and mouse embryonic
fibroblasts (MEF). Furthermore, histopathological and histomorphological
assessments are conducted on 150 male Wistar rats whitin four experimental
groups to evaluate the efficiency of the prepared burn ointment. We found a
significant wound healing in both macroscopical observations and microscopical
evaluations. Both curcumin and honey show strong antimicrobial effects with no
cytotoxicity. Also, the histopathological results present a considerable and
comparable wound re-epithelization in the a group of rats treated with both
honey and curcumin after 7 days. The burn ointment containing curcumin, honey,
and potassium alum show considerable efficacy in accelerating the healing of
experimentally-induced burn wounds in animals. Th novel onement product is
propose as a powerful alternative for the topical treatment of burn injuries.</description><subject>Quantitative Biology - Tissues and Organs</subject><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>GOX</sourceid><recordid>eNotkMtOwzAQRb1hgQofwAp_QBMcOw97GaJCkSq1Ekgso7Fjg6XErhynomt-nCZlMzPSvXMWB6GHjKQ5LwryBOHHnlJKsyzNMsHELfrdnKCfIFrvsDc4fmtcu2glqKiDhR6D6_Cnny5zq6G37gsfgj_qEK0e5w_Az1NweG9dHLSLuPEugnVzsZmCmgbr1njrnT6vF9bBRxhHOw247ufwct2hGwP9qO__9wq9v2w-mm2y27--NfUugbISiahowQtRZooryRgQyQktu6rKJdO6ypmUvCK5UYLkHTNcGkOEYgUvNVVUsBV6vFIXCe0x2AHCuZ1ltIsM9gfGgFty</recordid><startdate>20221121</startdate><enddate>20221121</enddate><creator>Shahbandeh, Mahsa</creator><creator>Salehi, Mahsa Amin</creator><creator>Soltanyzadeh, Maryam</creator><creator>Mirzaei, Mehrnaz</creator><creator>Maleki, Ali</creator><creator>rad, Abdolkarim Chehregani</creator><creator>Fatemi, Mohammad Javad</creator><creator>Mirnejad, Reza</creator><creator>Dahmardehei, Mostafa</creator><scope>ALC</scope><scope>GOX</scope></search><sort><creationdate>20221121</creationdate><title>Evaluation of the Antibacterial and Wound Healing Properties of a Burn Ointment Containing Curcumin, Honey, and Potassium Aluminium</title><author>Shahbandeh, Mahsa ; Salehi, Mahsa Amin ; Soltanyzadeh, Maryam ; Mirzaei, Mehrnaz ; Maleki, Ali ; rad, Abdolkarim Chehregani ; Fatemi, Mohammad Javad ; Mirnejad, Reza ; Dahmardehei, Mostafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a679-972585961c8cb33a0b8026d774b3ee743bb8704fc904d3f8bff09c3586e2c293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Quantitative Biology - Tissues and Organs</topic><toplevel>online_resources</toplevel><creatorcontrib>Shahbandeh, Mahsa</creatorcontrib><creatorcontrib>Salehi, Mahsa Amin</creatorcontrib><creatorcontrib>Soltanyzadeh, Maryam</creatorcontrib><creatorcontrib>Mirzaei, Mehrnaz</creatorcontrib><creatorcontrib>Maleki, Ali</creatorcontrib><creatorcontrib>rad, Abdolkarim Chehregani</creatorcontrib><creatorcontrib>Fatemi, Mohammad Javad</creatorcontrib><creatorcontrib>Mirnejad, Reza</creatorcontrib><creatorcontrib>Dahmardehei, Mostafa</creatorcontrib><collection>arXiv Quantitative Biology</collection><collection>arXiv.org</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Shahbandeh, Mahsa</au><au>Salehi, Mahsa Amin</au><au>Soltanyzadeh, Maryam</au><au>Mirzaei, Mehrnaz</au><au>Maleki, Ali</au><au>rad, Abdolkarim Chehregani</au><au>Fatemi, Mohammad Javad</au><au>Mirnejad, Reza</au><au>Dahmardehei, Mostafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Antibacterial and Wound Healing Properties of a Burn Ointment Containing Curcumin, Honey, and Potassium Aluminium</atitle><date>2022-11-21</date><risdate>2022</risdate><abstract>Burn wounds can severely trouble the health system and life quality of
patients. The present study aimed to analyze the synergistic healing properties
of curcumin, honey, and potassium alum substances merged in a newly-devised
burn ointment on second-degree burn wounds in rats. The MIC and MBC tests on
200 clinical isolates of Pseudomonas aeruginous are compared to imipenem in
vitro. Their killing time and cytotoxicity are also studied using a standard
isolate of P. aeruginous, fibroblast stem cells (FSC) and mouse embryonic
fibroblasts (MEF). Furthermore, histopathological and histomorphological
assessments are conducted on 150 male Wistar rats whitin four experimental
groups to evaluate the efficiency of the prepared burn ointment. We found a
significant wound healing in both macroscopical observations and microscopical
evaluations. Both curcumin and honey show strong antimicrobial effects with no
cytotoxicity. Also, the histopathological results present a considerable and
comparable wound re-epithelization in the a group of rats treated with both
honey and curcumin after 7 days. The burn ointment containing curcumin, honey,
and potassium alum show considerable efficacy in accelerating the healing of
experimentally-induced burn wounds in animals. Th novel onement product is
propose as a powerful alternative for the topical treatment of burn injuries.</abstract><doi>10.48550/arxiv.2211.11939</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Quantitative Biology - Tissues and Organs |
| title | Evaluation of the Antibacterial and Wound Healing Properties of a Burn Ointment Containing Curcumin, Honey, and Potassium Aluminium |
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