DNA origami
Biological materials are self-assembled with near-atomic precision in living cells, whereas synthetic 3D structures generally lack such precision and controllability. Recently, DNA nanotechnology, especially DNA origami technology, has been useful in the bottom-up fabrication of well-defined nanostr...
Gespeichert in:
| Veröffentlicht in: | arXiv.org 2021-04 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | arXiv.org |
| container_volume | |
| creator | Dey, Swarup Fan, Chunhai Gothelf, Kurt V Jiang, Li Lin, Chenxiang Liu, Longfei Liu, Na Nijenhuis, Minke A D Sacca, Barbara Simmel, Friedrich C Yan, Hao Zhan, Pengfei |
| description | Biological materials are self-assembled with near-atomic precision in living cells, whereas synthetic 3D structures generally lack such precision and controllability. Recently, DNA nanotechnology, especially DNA origami technology, has been useful in the bottom-up fabrication of well-defined nanostructures ranging from tens of nanometres to sub-micrometres. In this Primer, we summarize the methodologies of DNA origami technology, including origami design, synthesis, functionalization and characterization. We highlight applications of origami structures in nanofabrication, nanophotonics and nanoelectronics, catalysis, computation, molecular machines, bioimaging, drug delivery and biophysics. We identify challenges for the field, including size limits, stability issues and the scale of production, and discuss their possible solutions. We further provide an outlook on next-generation DNA origami techniques that will allow in vivo synthesis and multiscale manufacturing. |
| doi_str_mv | 10.48550/arxiv.2104.15016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_arxiv</sourceid><recordid>TN_cdi_arxiv_primary_2104_15016</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2521277754</sourcerecordid><originalsourceid>FETCH-LOGICAL-a524-e913a8300b7bf38403f2c7f5de1d3358e0bb0d0a725151ef0c87ad5f46ea65143</originalsourceid><addsrcrecordid>eNotzktLw0AUBeBBECyxP8CVguvE-5ibGZelPioU3XQ_3DQzkmJNnVjRf29sXZ3N4ZzPmAuEynoRuNH83X1VhGArFMD6xEyIGUtvic7MdBg2AEC1IxGemOLueXbV5-5Vt925OU36NsTpfxZm9XC_mi_K5cvj03y2LFXIlvEWWT0DNK5J7C1worVL0kZsmcVHaBpoQccDFIwJ1t5pK8nWUWtBy4W5PM4epGGXu63mn_AnDgfx2Lg-Nna5_9jH4TNs-n1-H02BhJCcc2L5F4PlQCE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2521277754</pqid></control><display><type>article</type><title>DNA origami</title><source>arXiv.org</source><source>Open Access: Freely Accessible Journals by multiple vendors</source><creator>Dey, Swarup ; Fan, Chunhai ; Gothelf, Kurt V ; Jiang, Li ; Lin, Chenxiang ; Liu, Longfei ; Liu, Na ; Nijenhuis, Minke A D ; Sacca, Barbara ; Simmel, Friedrich C ; Yan, Hao ; Zhan, Pengfei</creator><creatorcontrib>Dey, Swarup ; Fan, Chunhai ; Gothelf, Kurt V ; Jiang, Li ; Lin, Chenxiang ; Liu, Longfei ; Liu, Na ; Nijenhuis, Minke A D ; Sacca, Barbara ; Simmel, Friedrich C ; Yan, Hao ; Zhan, Pengfei</creatorcontrib><description>Biological materials are self-assembled with near-atomic precision in living cells, whereas synthetic 3D structures generally lack such precision and controllability. Recently, DNA nanotechnology, especially DNA origami technology, has been useful in the bottom-up fabrication of well-defined nanostructures ranging from tens of nanometres to sub-micrometres. In this Primer, we summarize the methodologies of DNA origami technology, including origami design, synthesis, functionalization and characterization. We highlight applications of origami structures in nanofabrication, nanophotonics and nanoelectronics, catalysis, computation, molecular machines, bioimaging, drug delivery and biophysics. We identify challenges for the field, including size limits, stability issues and the scale of production, and discuss their possible solutions. We further provide an outlook on next-generation DNA origami techniques that will allow in vivo synthesis and multiscale manufacturing.</description><identifier>EISSN: 2331-8422</identifier><identifier>DOI: 10.48550/arxiv.2104.15016</identifier><language>eng</language><publisher>Ithaca: Cornell University Library, arXiv.org</publisher><subject>Biological materials ; Biophysics ; Controllability ; In vivo methods and tests ; Medical imaging ; Molecular machines ; Nanoelectronics ; Nanofabrication ; Nanotechnology ; Physics - Biological Physics ; Physics - Soft Condensed Matter ; Self-assembly ; Synthesis</subject><ispartof>arXiv.org, 2021-04</ispartof><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>http://creativecommons.org/licenses/by/4.0</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>228,230,776,780,881,27902</link.rule.ids><backlink>$$Uhttps://doi.org/10.48550/arXiv.2104.15016$$DView paper in arXiv$$Hfree_for_read</backlink><backlink>$$Uhttps://doi.org/10.1038/s43586-020-00009-8$$DView published paper (Access to full text may be restricted)$$Hfree_for_read</backlink></links><search><creatorcontrib>Dey, Swarup</creatorcontrib><creatorcontrib>Fan, Chunhai</creatorcontrib><creatorcontrib>Gothelf, Kurt V</creatorcontrib><creatorcontrib>Jiang, Li</creatorcontrib><creatorcontrib>Lin, Chenxiang</creatorcontrib><creatorcontrib>Liu, Longfei</creatorcontrib><creatorcontrib>Liu, Na</creatorcontrib><creatorcontrib>Nijenhuis, Minke A D</creatorcontrib><creatorcontrib>Sacca, Barbara</creatorcontrib><creatorcontrib>Simmel, Friedrich C</creatorcontrib><creatorcontrib>Yan, Hao</creatorcontrib><creatorcontrib>Zhan, Pengfei</creatorcontrib><title>DNA origami</title><title>arXiv.org</title><description>Biological materials are self-assembled with near-atomic precision in living cells, whereas synthetic 3D structures generally lack such precision and controllability. Recently, DNA nanotechnology, especially DNA origami technology, has been useful in the bottom-up fabrication of well-defined nanostructures ranging from tens of nanometres to sub-micrometres. In this Primer, we summarize the methodologies of DNA origami technology, including origami design, synthesis, functionalization and characterization. We highlight applications of origami structures in nanofabrication, nanophotonics and nanoelectronics, catalysis, computation, molecular machines, bioimaging, drug delivery and biophysics. We identify challenges for the field, including size limits, stability issues and the scale of production, and discuss their possible solutions. We further provide an outlook on next-generation DNA origami techniques that will allow in vivo synthesis and multiscale manufacturing.</description><subject>Biological materials</subject><subject>Biophysics</subject><subject>Controllability</subject><subject>In vivo methods and tests</subject><subject>Medical imaging</subject><subject>Molecular machines</subject><subject>Nanoelectronics</subject><subject>Nanofabrication</subject><subject>Nanotechnology</subject><subject>Physics - Biological Physics</subject><subject>Physics - Soft Condensed Matter</subject><subject>Self-assembly</subject><subject>Synthesis</subject><issn>2331-8422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>GOX</sourceid><recordid>eNotzktLw0AUBeBBECyxP8CVguvE-5ibGZelPioU3XQ_3DQzkmJNnVjRf29sXZ3N4ZzPmAuEynoRuNH83X1VhGArFMD6xEyIGUtvic7MdBg2AEC1IxGemOLueXbV5-5Vt925OU36NsTpfxZm9XC_mi_K5cvj03y2LFXIlvEWWT0DNK5J7C1worVL0kZsmcVHaBpoQccDFIwJ1t5pK8nWUWtBy4W5PM4epGGXu63mn_AnDgfx2Lg-Nna5_9jH4TNs-n1-H02BhJCcc2L5F4PlQCE</recordid><startdate>20210430</startdate><enddate>20210430</enddate><creator>Dey, Swarup</creator><creator>Fan, Chunhai</creator><creator>Gothelf, Kurt V</creator><creator>Jiang, Li</creator><creator>Lin, Chenxiang</creator><creator>Liu, Longfei</creator><creator>Liu, Na</creator><creator>Nijenhuis, Minke A D</creator><creator>Sacca, Barbara</creator><creator>Simmel, Friedrich C</creator><creator>Yan, Hao</creator><creator>Zhan, Pengfei</creator><general>Cornell University Library, arXiv.org</general><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>L6V</scope><scope>M7S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>GOX</scope></search><sort><creationdate>20210430</creationdate><title>DNA origami</title><author>Dey, Swarup ; Fan, Chunhai ; Gothelf, Kurt V ; Jiang, Li ; Lin, Chenxiang ; Liu, Longfei ; Liu, Na ; Nijenhuis, Minke A D ; Sacca, Barbara ; Simmel, Friedrich C ; Yan, Hao ; Zhan, Pengfei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a524-e913a8300b7bf38403f2c7f5de1d3358e0bb0d0a725151ef0c87ad5f46ea65143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biological materials</topic><topic>Biophysics</topic><topic>Controllability</topic><topic>In vivo methods and tests</topic><topic>Medical imaging</topic><topic>Molecular machines</topic><topic>Nanoelectronics</topic><topic>Nanofabrication</topic><topic>Nanotechnology</topic><topic>Physics - Biological Physics</topic><topic>Physics - Soft Condensed Matter</topic><topic>Self-assembly</topic><topic>Synthesis</topic><toplevel>online_resources</toplevel><creatorcontrib>Dey, Swarup</creatorcontrib><creatorcontrib>Fan, Chunhai</creatorcontrib><creatorcontrib>Gothelf, Kurt V</creatorcontrib><creatorcontrib>Jiang, Li</creatorcontrib><creatorcontrib>Lin, Chenxiang</creatorcontrib><creatorcontrib>Liu, Longfei</creatorcontrib><creatorcontrib>Liu, Na</creatorcontrib><creatorcontrib>Nijenhuis, Minke A D</creatorcontrib><creatorcontrib>Sacca, Barbara</creatorcontrib><creatorcontrib>Simmel, Friedrich C</creatorcontrib><creatorcontrib>Yan, Hao</creatorcontrib><creatorcontrib>Zhan, Pengfei</creatorcontrib><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>arXiv.org</collection><jtitle>arXiv.org</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dey, Swarup</au><au>Fan, Chunhai</au><au>Gothelf, Kurt V</au><au>Jiang, Li</au><au>Lin, Chenxiang</au><au>Liu, Longfei</au><au>Liu, Na</au><au>Nijenhuis, Minke A D</au><au>Sacca, Barbara</au><au>Simmel, Friedrich C</au><au>Yan, Hao</au><au>Zhan, Pengfei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA origami</atitle><jtitle>arXiv.org</jtitle><date>2021-04-30</date><risdate>2021</risdate><eissn>2331-8422</eissn><abstract>Biological materials are self-assembled with near-atomic precision in living cells, whereas synthetic 3D structures generally lack such precision and controllability. Recently, DNA nanotechnology, especially DNA origami technology, has been useful in the bottom-up fabrication of well-defined nanostructures ranging from tens of nanometres to sub-micrometres. In this Primer, we summarize the methodologies of DNA origami technology, including origami design, synthesis, functionalization and characterization. We highlight applications of origami structures in nanofabrication, nanophotonics and nanoelectronics, catalysis, computation, molecular machines, bioimaging, drug delivery and biophysics. We identify challenges for the field, including size limits, stability issues and the scale of production, and discuss their possible solutions. We further provide an outlook on next-generation DNA origami techniques that will allow in vivo synthesis and multiscale manufacturing.</abstract><cop>Ithaca</cop><pub>Cornell University Library, arXiv.org</pub><doi>10.48550/arxiv.2104.15016</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 2331-8422 |
| ispartof | arXiv.org, 2021-04 |
| issn | 2331-8422 |
| language | eng |
| recordid | cdi_arxiv_primary_2104_15016 |
| source | arXiv.org; Open Access: Freely Accessible Journals by multiple vendors |
| subjects | Biological materials Biophysics Controllability In vivo methods and tests Medical imaging Molecular machines Nanoelectronics Nanofabrication Nanotechnology Physics - Biological Physics Physics - Soft Condensed Matter Self-assembly Synthesis |
| title | DNA origami |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T17%3A27%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_arxiv&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=DNA%20origami&rft.jtitle=arXiv.org&rft.au=Dey,%20Swarup&rft.date=2021-04-30&rft.eissn=2331-8422&rft_id=info:doi/10.48550/arxiv.2104.15016&rft_dat=%3Cproquest_arxiv%3E2521277754%3C/proquest_arxiv%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2521277754&rft_id=info:pmid/&rfr_iscdi=true |