Signaling activations through G-protein-coupled-receptor aggregations
Eukaryotic cells transmit extracellular signal information to cellular interiors through the formation of a ternary complex made up of a ligand (or agonist), G-protein, and G-protein coupled receptor (GPCR). Previously formalized theories of ternary complex formation have mainly assumed that observa...
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| creator | Watabe, Masaki Yoshimura, Hideaki Arjunan, Satya N V Kaizu, Kazunari Takahashi, Koichi |
| description | Eukaryotic cells transmit extracellular signal information to cellular interiors through the formation of a ternary complex made up of a ligand (or agonist), G-protein, and G-protein coupled receptor (GPCR). Previously formalized theories of ternary complex formation have mainly assumed that observable states of receptors can only take the form of monomers. Here, we propose a multiary complex model of GPCR signaling activations via the vector representation of various unobserved aggregated receptor states. Our results from model simulations imply that receptor aggregation processes can govern cooperative effects in a regime inaccessible by previous theories. In particular, we show how the affinity of ligand-receptor binding can be largely varied by various oligomer formations in the low concentration range of G-protein stimulus. |
| doi_str_mv | 10.48550/arxiv.2004.07440 |
| format | Article |
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| subjects | Agglomeration Complex formation Computer simulation Formations Ligands Proteins Quantitative Biology - Biomolecules Quantitative Biology - Molecular Networks Receptors Signaling |
| title | Signaling activations through G-protein-coupled-receptor aggregations |
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