Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography
We demonstrate that simultaneous application of optical clearing agents (OCAs) and complex wavefront shaping in optical coherence tomography (OCT) can provide significant enhancement of the penetration depth and imaging quality. OCA reduces optical inhomogeneity of a highly scattering sample, and th...
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| Veröffentlicht in: | arXiv.org 2016-10 |
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| creator | Yu, Hyeonseung Lee, Peter YoungJu Jo Lee, KyeoReh Tuchin, Valery V Jeong, Yong Park, YongKeun |
| description | We demonstrate that simultaneous application of optical clearing agents (OCAs) and complex wavefront shaping in optical coherence tomography (OCT) can provide significant enhancement of the penetration depth and imaging quality. OCA reduces optical inhomogeneity of a highly scattering sample, and the wavefront shaping of illumination light controls multiple scattering, resulting in an enhancement of the penetration depth and signal-to-noise ratio. A tissue phantom study shows that concurrent applications of OCA and wavefront shaping successfully operate in OCT imaging. The penetration depth enhancement is further demonstrated for ex vivo mouse ears, revealing hidden structures inaccessible with conventional OCT imaging. |
| doi_str_mv | 10.48550/arxiv.1610.01658 |
| format | Article |
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| subjects | Clearing Imaging Inhomogeneity Light Medical imaging Optical Coherence Tomography Penetration depth Physics - Biological Physics Physics - Optics Scattering Tomography |
| title | Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography |
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