Phase-separation transitions in asymmetric lipid bilayers
Morphological transitions of phase separation associated with the asymmetry of lipid composition were investigated using micrometer-sized vesicles of lipid bilayers made from a lipid mixture. The complete macro-phase-separated morphology undergoes a transition to a micro-phase-separation-like morpho...
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| creator | Shimobayashi, Shunsuke F Ichikawa, Masatoshi Taniguchi, Takashi |
| description | Morphological transitions of phase separation associated with the asymmetry
of lipid composition were investigated using micrometer-sized vesicles of lipid
bilayers made from a lipid mixture. The complete macro-phase-separated
morphology undergoes a transition to a micro-phase-separation-like morphology
via a lorate morphology as a metastable state. The transition leads to the
emergence of monodisperse nanosized domains through repeated domain scission
events. Moreover, we have numerically confirmed the transitions using the
time-dependent Ginzburg-Landau model describing phase separation and the
bending elastic membrane, which is quantitatively consistent with experimental
results by fixing one free parameter. Our findings suggest that the local
spontaneous curvature due to the asymmetric composition plays an essential role
in the thermodynamic stabilization of micro-phase separation in lipid bilayers. |
| doi_str_mv | 10.48550/arxiv.1504.03038 |
| format | Article |
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of lipid composition were investigated using micrometer-sized vesicles of lipid
bilayers made from a lipid mixture. The complete macro-phase-separated
morphology undergoes a transition to a micro-phase-separation-like morphology
via a lorate morphology as a metastable state. The transition leads to the
emergence of monodisperse nanosized domains through repeated domain scission
events. Moreover, we have numerically confirmed the transitions using the
time-dependent Ginzburg-Landau model describing phase separation and the
bending elastic membrane, which is quantitatively consistent with experimental
results by fixing one free parameter. Our findings suggest that the local
spontaneous curvature due to the asymmetric composition plays an essential role
in the thermodynamic stabilization of micro-phase separation in lipid bilayers.</description><identifier>DOI: 10.48550/arxiv.1504.03038</identifier><language>eng</language><subject>Physics - Biological Physics ; Physics - Soft Condensed Matter ; Quantitative Biology - Subcellular Processes</subject><creationdate>2015-04</creationdate><rights>http://arxiv.org/licenses/nonexclusive-distrib/1.0</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>228,230,776,881</link.rule.ids><linktorsrc>$$Uhttps://arxiv.org/abs/1504.03038$$EView_record_in_Cornell_University$$FView_record_in_$$GCornell_University$$Hfree_for_read</linktorsrc><backlink>$$Uhttps://doi.org/10.48550/arXiv.1504.03038$$DView paper in arXiv$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimobayashi, Shunsuke F</creatorcontrib><creatorcontrib>Ichikawa, Masatoshi</creatorcontrib><creatorcontrib>Taniguchi, Takashi</creatorcontrib><title>Phase-separation transitions in asymmetric lipid bilayers</title><description>Morphological transitions of phase separation associated with the asymmetry
of lipid composition were investigated using micrometer-sized vesicles of lipid
bilayers made from a lipid mixture. The complete macro-phase-separated
morphology undergoes a transition to a micro-phase-separation-like morphology
via a lorate morphology as a metastable state. The transition leads to the
emergence of monodisperse nanosized domains through repeated domain scission
events. Moreover, we have numerically confirmed the transitions using the
time-dependent Ginzburg-Landau model describing phase separation and the
bending elastic membrane, which is quantitatively consistent with experimental
results by fixing one free parameter. Our findings suggest that the local
spontaneous curvature due to the asymmetric composition plays an essential role
in the thermodynamic stabilization of micro-phase separation in lipid bilayers.</description><subject>Physics - Biological Physics</subject><subject>Physics - Soft Condensed Matter</subject><subject>Quantitative Biology - Subcellular Processes</subject><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>GOX</sourceid><recordid>eNotj71qwzAURrV0KGkfoFP1AnalSleWxhD6B4FmyG6uoit6wXaMZEr99iVpp_NNh-8I8aBVaz2AesLyw9-tBmVbZZTxtyIcvrBSU2nGggufJ7kUnCpfZpU8SazrONJS-CQHnjnJyAOuVOqduMk4VLr_50YcX1-Ou_dm__n2sdvuG3SdbyIp6vzJxQ5yDDYCkgcTE6IjIARvn1PSxgUL2SadAwXtOnKQc9QGwGzE45_2-r2fC49Y1v7S0F8bzC-jSkKV</recordid><startdate>20150412</startdate><enddate>20150412</enddate><creator>Shimobayashi, Shunsuke F</creator><creator>Ichikawa, Masatoshi</creator><creator>Taniguchi, Takashi</creator><scope>ALC</scope><scope>GOX</scope></search><sort><creationdate>20150412</creationdate><title>Phase-separation transitions in asymmetric lipid bilayers</title><author>Shimobayashi, Shunsuke F ; Ichikawa, Masatoshi ; Taniguchi, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a678-be0e78c6b75fb94b5ae853bdaa6e5ea5842dd136945f4d1f9e9167e65ffb13553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Physics - Biological Physics</topic><topic>Physics - Soft Condensed Matter</topic><topic>Quantitative Biology - Subcellular Processes</topic><toplevel>online_resources</toplevel><creatorcontrib>Shimobayashi, Shunsuke F</creatorcontrib><creatorcontrib>Ichikawa, Masatoshi</creatorcontrib><creatorcontrib>Taniguchi, Takashi</creatorcontrib><collection>arXiv Quantitative Biology</collection><collection>arXiv.org</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Shimobayashi, Shunsuke F</au><au>Ichikawa, Masatoshi</au><au>Taniguchi, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phase-separation transitions in asymmetric lipid bilayers</atitle><date>2015-04-12</date><risdate>2015</risdate><abstract>Morphological transitions of phase separation associated with the asymmetry
of lipid composition were investigated using micrometer-sized vesicles of lipid
bilayers made from a lipid mixture. The complete macro-phase-separated
morphology undergoes a transition to a micro-phase-separation-like morphology
via a lorate morphology as a metastable state. The transition leads to the
emergence of monodisperse nanosized domains through repeated domain scission
events. Moreover, we have numerically confirmed the transitions using the
time-dependent Ginzburg-Landau model describing phase separation and the
bending elastic membrane, which is quantitatively consistent with experimental
results by fixing one free parameter. Our findings suggest that the local
spontaneous curvature due to the asymmetric composition plays an essential role
in the thermodynamic stabilization of micro-phase separation in lipid bilayers.</abstract><doi>10.48550/arxiv.1504.03038</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Physics - Biological Physics Physics - Soft Condensed Matter Quantitative Biology - Subcellular Processes |
| title | Phase-separation transitions in asymmetric lipid bilayers |
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