Dual-target function validation of single-particle selection from low-contrast cryo-electron micrographs

Weak-signal detection and single-particle selection from low-contrast micrographs of frozen hydrated biomolecules by cryo-electron microscopy (cryo-EM) presents a practical challenge. Cryo-EM image contrast degrades as the size of biomolecules of structural interest decreases. When the image contras...

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Veröffentlicht in:	arXiv.org 2013-09
Hauptverfasser:	Mao, Youdong, Castillo-Menendez, Luis R, Sodroski, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomolecules Computer simulation Detergents Electron micrographs Image contrast Image degradation Quantitative Biology - Quantitative Methods Signal detection Template matching
Online-Zugang:	Volltext
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