Methods for scoring the collective effect of SNPs: Minor alleles of common SNPs quantitatively affect traits/diseases and are under both positive and negative selection

Sci China Life Sci. 57:876-888. (2014) Most common SNPs are popularly assumed to be neutral. We here developed novel methods to examine in animal models and humans whether extreme amount of minor alleles (MAs) carried by an individual may represent extreme trait values and common diseases. We analyz...

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Hauptverfasser:	Yuan, Dejian, Zhu, Zuobin, Tan, Xiaohua, Liang, Jie, Zeng, Ceng, Zhang, Jiegen, Chen, Jun, Ma, Long, Dogan, Ayca, Brockmann, Gudrun, Goldmann, Oliver, Medina, Eva, Rice, Amanda D, Moyer, Richard W, Man, Xian, Yi, Ke, Li, Yanke, Lu, Qing, Huang, Yimin, Wang, Dapeng, Yu, Jun, Guo, Hui, Xia, Kun, Huang, Shi
Format:	Artikel
Sprache:	eng
Schlagworte:	Quantitative Biology - Genomics Quantitative Biology - Populations and Evolution
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