Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myoc...

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Veröffentlicht in:arXiv.org 2011-03
Hauptverfasser: Moskvin, A S, Ryvkin, A M, Solovyova, O E, Markhasin, V S
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Physics - Biological Physics
Physics - Mesoscale and Nanoscale Physics
Physics - Soft Condensed Matter
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Ryvkin, A M
Solovyova, O E
Markhasin, V S
description We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca\(^{2+}\) SR overload.
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subjects Physics - Biological Physics
Physics - Mesoscale and Nanoscale Physics
Physics - Soft Condensed Matter
title Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating
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