Controlling protein crystal growth rate by means of temperature
We have proposed a model to analyze the growth kinetics of lysozyme crystals/aggregates under non-isothermal conditions. The model was formulated through an analysis of the entropy production of the growth process which was obtained by taking into account the explicit dependence of the free energy o...
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| creator | Santamaria-Holek, I Gadomski, Adam Rubi, J. M |
| description | We have proposed a model to analyze the growth kinetics of lysozyme
crystals/aggregates under non-isothermal conditions. The model was formulated
through an analysis of the entropy production of the growth process which was
obtained by taking into account the explicit dependence of the free energy on
the temperature. We found that the growth process is coupled with temperature
variations resulting in a novel Soret-type effect. We identified the surface
entropy of the crystal/aggregate as a decisive ingredient controlling the
behavior of the average growth rate as a function of temperature. The behavior
of the Gibbs free energy as a function of temperature is also analyzed. The
agreement between theory and experiments is very good in the range of
temperatures considered. |
| doi_str_mv | 10.48550/arxiv.1103.4551 |
| format | Article |
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crystals/aggregates under non-isothermal conditions. The model was formulated
through an analysis of the entropy production of the growth process which was
obtained by taking into account the explicit dependence of the free energy on
the temperature. We found that the growth process is coupled with temperature
variations resulting in a novel Soret-type effect. We identified the surface
entropy of the crystal/aggregate as a decisive ingredient controlling the
behavior of the average growth rate as a function of temperature. The behavior
of the Gibbs free energy as a function of temperature is also analyzed. The
agreement between theory and experiments is very good in the range of
temperatures considered.</description><identifier>DOI: 10.48550/arxiv.1103.4551</identifier><language>eng</language><subject>Physics - Materials Science</subject><creationdate>2011-03</creationdate><rights>http://arxiv.org/licenses/nonexclusive-distrib/1.0</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>228,230,776,881</link.rule.ids><linktorsrc>$$Uhttps://arxiv.org/abs/1103.4551$$EView_record_in_Cornell_University$$FView_record_in_$$GCornell_University$$Hfree_for_read</linktorsrc><backlink>$$Uhttps://doi.org/10.48550/arXiv.1103.4551$$DView paper in arXiv$$Hfree_for_read</backlink></links><search><creatorcontrib>Santamaria-Holek, I</creatorcontrib><creatorcontrib>Gadomski, Adam</creatorcontrib><creatorcontrib>Rubi, J. M</creatorcontrib><title>Controlling protein crystal growth rate by means of temperature</title><description>We have proposed a model to analyze the growth kinetics of lysozyme
crystals/aggregates under non-isothermal conditions. The model was formulated
through an analysis of the entropy production of the growth process which was
obtained by taking into account the explicit dependence of the free energy on
the temperature. We found that the growth process is coupled with temperature
variations resulting in a novel Soret-type effect. We identified the surface
entropy of the crystal/aggregate as a decisive ingredient controlling the
behavior of the average growth rate as a function of temperature. The behavior
of the Gibbs free energy as a function of temperature is also analyzed. The
agreement between theory and experiments is very good in the range of
temperatures considered.</description><subject>Physics - Materials Science</subject><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>GOX</sourceid><recordid>eNotz7tOxDAQhWE3FGihp0J-gQQ7k1l7K4QibtJK22wfjePxEimJI8dc8vawQHWkvzjSJ8SNVmVtEdUdpa_-o9RaQVkj6ktx38QppzgM_XSSc4qZ-0l2aV0yDfKU4md-k4kyS7fKkWlaZAwy8zjzT31PfCUuAg0LX__vRhyfHo_NS7E_PL82D_uCtqgLQm8rZ1hVjqzqtoihAr3zwSgK1oBxzpjKBqi5Bk3AaNB0vtPaux0oDxtx-3f7C2jn1I-U1vYMac8Q-Aa_xUON</recordid><startdate>20110323</startdate><enddate>20110323</enddate><creator>Santamaria-Holek, I</creator><creator>Gadomski, Adam</creator><creator>Rubi, J. M</creator><scope>GOX</scope></search><sort><creationdate>20110323</creationdate><title>Controlling protein crystal growth rate by means of temperature</title><author>Santamaria-Holek, I ; Gadomski, Adam ; Rubi, J. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a651-a5d82b7e02ba80c655f2319df70af8737bb7728f34e431a3e5757cdc11db930d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Physics - Materials Science</topic><toplevel>online_resources</toplevel><creatorcontrib>Santamaria-Holek, I</creatorcontrib><creatorcontrib>Gadomski, Adam</creatorcontrib><creatorcontrib>Rubi, J. M</creatorcontrib><collection>arXiv.org</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Santamaria-Holek, I</au><au>Gadomski, Adam</au><au>Rubi, J. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlling protein crystal growth rate by means of temperature</atitle><date>2011-03-23</date><risdate>2011</risdate><abstract>We have proposed a model to analyze the growth kinetics of lysozyme
crystals/aggregates under non-isothermal conditions. The model was formulated
through an analysis of the entropy production of the growth process which was
obtained by taking into account the explicit dependence of the free energy on
the temperature. We found that the growth process is coupled with temperature
variations resulting in a novel Soret-type effect. We identified the surface
entropy of the crystal/aggregate as a decisive ingredient controlling the
behavior of the average growth rate as a function of temperature. The behavior
of the Gibbs free energy as a function of temperature is also analyzed. The
agreement between theory and experiments is very good in the range of
temperatures considered.</abstract><doi>10.48550/arxiv.1103.4551</doi><oa>free_for_read</oa></addata></record> |
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| title | Controlling protein crystal growth rate by means of temperature |
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