The Ability of Vitamin a , Alone or in Combination with Vitamins C and E , in Ameliorating the Side Effects of Penicillin and Streptomycin on Hepatic Damage in Guinea Pigs
The administration of vitamin A (10000 IU/kg b.w), vitamin A, C and E (10000 IU/kg, 100 mg/kg 100 mg/kg b.w), penicillin (50000 IU/kg b.w), penicillin + vitamin A, penicillin + vitamin A, C and E, streptomycin (50 mg/kg b.w), streptomycin + vitamin A, streptomycin + vitamins A, C and E for 30 days c...
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| Veröffentlicht in: | Jordan journal of biological sciences 2014, Vol.7 (2), p.127-132 |
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| container_title | Jordan journal of biological sciences |
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| creator | Al-Eryani , Mohammed A. Y Shediwah , Fatma M. H Al-Shaibani , Elham A. S Salih , Elias M. A Al-Awar , Mohammed S. A |
| description | The administration of vitamin A (10000 IU/kg b.w), vitamin A, C and E (10000 IU/kg, 100 mg/kg 100 mg/kg b.w),
penicillin (50000 IU/kg b.w), penicillin + vitamin A, penicillin + vitamin A, C and E, streptomycin (50 mg/kg b.w),
streptomycin + vitamin A, streptomycin + vitamins A, C and E for 30 days caused a significant increase in the levels of
AST, ALT and ALP, and also caused a significant decrease in the levels of total protein and albumin in penicillin and
streptomycin treated groups. However, co-administration of penicillin and streptomycin with vitamin A alone or in
combination with vitamins C and E ameliorated the harmful effects of penicillin and streptomycin in most of the tested
parameters. Vitamin A, either alone or in combination with vitamin C and E, has a protective effect on the histological
changes of liver tissues induced either by penicillin or streptomycin administration. The result of the present work reveals
for the first time that vitamin A alone or in combination with vitamin C and E plays an important role as cytoprotective
compounds on hepatic damage in guinea pigs. Hence, further studies on the possible uses of vitamins as protective
compounds during treatment with antibiotics are needed. |
| doi_str_mv | 10.12816/0008226 |
| format | Article |
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penicillin (50000 IU/kg b.w), penicillin + vitamin A, penicillin + vitamin A, C and E, streptomycin (50 mg/kg b.w),
streptomycin + vitamin A, streptomycin + vitamins A, C and E for 30 days caused a significant increase in the levels of
AST, ALT and ALP, and also caused a significant decrease in the levels of total protein and albumin in penicillin and
streptomycin treated groups. However, co-administration of penicillin and streptomycin with vitamin A alone or in
combination with vitamins C and E ameliorated the harmful effects of penicillin and streptomycin in most of the tested
parameters. Vitamin A, either alone or in combination with vitamin C and E, has a protective effect on the histological
changes of liver tissues induced either by penicillin or streptomycin administration. The result of the present work reveals
for the first time that vitamin A alone or in combination with vitamin C and E plays an important role as cytoprotective
compounds on hepatic damage in guinea pigs. Hence, further studies on the possible uses of vitamins as protective
compounds during treatment with antibiotics are needed.</description><identifier>ISSN: 1995-6673</identifier><identifier>DOI: 10.12816/0008226</identifier><language>eng</language><publisher>Az Zarqa' - Jordan: The Hashemite University : The Deanship of Scientific Research and Graduate Studies</publisher><subject>ASCORBIC ACID ; LABORATORY ANIMALS ; LIVER DISEASES ; Penicillin ; PENICILLINS ; RETINOL ; SIDE EFFECTS ; Streptomycin ; THERAPY ; VITAMINS ; أمراض الكبد ; الأعراض الجانبية ; البنسلين ; البنسلينات ; التغذية ; الرتنول ; العلاج ; الفيتامينات ; المواد المضادة للبكتيريا ; حمض الأسكوربيك ; حيوانات المختبر</subject><ispartof>Jordan journal of biological sciences, 2014, Vol.7 (2), p.127-132</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://static.almanhal.com/covers/titl/56274/cover-lg.jpg</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids></links><search><creatorcontrib>Al-Eryani , Mohammed A. Y</creatorcontrib><creatorcontrib>Shediwah , Fatma M. H</creatorcontrib><creatorcontrib>Al-Shaibani , Elham A. S</creatorcontrib><creatorcontrib>Salih , Elias M. A</creatorcontrib><creatorcontrib>Al-Awar , Mohammed S. A</creatorcontrib><title>The Ability of Vitamin a , Alone or in Combination with Vitamins C and E , in Ameliorating the Side Effects of Penicillin and Streptomycin on Hepatic Damage in Guinea Pigs</title><title>Jordan journal of biological sciences</title><description>The administration of vitamin A (10000 IU/kg b.w), vitamin A, C and E (10000 IU/kg, 100 mg/kg 100 mg/kg b.w),
penicillin (50000 IU/kg b.w), penicillin + vitamin A, penicillin + vitamin A, C and E, streptomycin (50 mg/kg b.w),
streptomycin + vitamin A, streptomycin + vitamins A, C and E for 30 days caused a significant increase in the levels of
AST, ALT and ALP, and also caused a significant decrease in the levels of total protein and albumin in penicillin and
streptomycin treated groups. However, co-administration of penicillin and streptomycin with vitamin A alone or in
combination with vitamins C and E ameliorated the harmful effects of penicillin and streptomycin in most of the tested
parameters. Vitamin A, either alone or in combination with vitamin C and E, has a protective effect on the histological
changes of liver tissues induced either by penicillin or streptomycin administration. The result of the present work reveals
for the first time that vitamin A alone or in combination with vitamin C and E plays an important role as cytoprotective
compounds on hepatic damage in guinea pigs. Hence, further studies on the possible uses of vitamins as protective
compounds during treatment with antibiotics are needed.</description><subject>ASCORBIC ACID</subject><subject>LABORATORY ANIMALS</subject><subject>LIVER DISEASES</subject><subject>Penicillin</subject><subject>PENICILLINS</subject><subject>RETINOL</subject><subject>SIDE EFFECTS</subject><subject>Streptomycin</subject><subject>THERAPY</subject><subject>VITAMINS</subject><subject>أمراض الكبد</subject><subject>الأعراض الجانبية</subject><subject>البنسلين</subject><subject>البنسلينات</subject><subject>التغذية</subject><subject>الرتنول</subject><subject>العلاج</subject><subject>الفيتامينات</subject><subject>المواد المضادة للبكتيريا</subject><subject>حمض الأسكوربيك</subject><subject>حيوانات المختبر</subject><issn>1995-6673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpFkM9Kw0AQh3NQsNSCLyDs0YPV_dNkk2OItRUKFlq9hsnubLuSbEqyIn0mX9KtrfUyy-zvm29gouiG0QfGU5Y8UkpTzpOLaMCyLB4niRRX0ajvP0JAJRNc8kH0vd4iyStbW78nrSHv1kNjHQFyT_K6dUjajoS-aJvKOvC2deTL-u0f2JOCgNNkGviA5Q3Wtu0C5zbEB_XKaiRTY1D5_uBforPK1vVhRRhb-Q53vm32KnwE9Rx3YVaRJ2hggwfj7NM6BLK0m_46ujRQ9zg6vcPo7Xm6LubjxevspcgXY2AT6cdxrHXFqKFKi0SGklZJJlKsMqEYpSAUYgWoNBep0FoKkJyzrKJaGSOQimF0d_Sqru37Dk2562wD3b5ktPy9bXm6bUBvjyiGHA2cSSFTIeP_HOoG3BbqMxAnXE7EDzMcgi8</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Al-Eryani , Mohammed A. Y</creator><creator>Shediwah , Fatma M. H</creator><creator>Al-Shaibani , Elham A. S</creator><creator>Salih , Elias M. A</creator><creator>Al-Awar , Mohammed S. A</creator><general>The Hashemite University : The Deanship of Scientific Research and Graduate Studies</general><general>The Hashemite University, Deanship of Academic Research and Graduate</general><scope>~6Z</scope><scope>ADJCN</scope><scope>AHFXO</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2014</creationdate><title>The Ability of Vitamin a , Alone or in Combination with Vitamins C and E , in Ameliorating the Side Effects of Penicillin and Streptomycin on Hepatic Damage in Guinea Pigs</title><author>Al-Eryani , Mohammed A. Y ; Shediwah , Fatma M. H ; Al-Shaibani , Elham A. S ; Salih , Elias M. A ; Al-Awar , Mohammed S. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a147t-55ddb10f0cd367cd38b6938eb93c100a3ceebaecd2383dd73a72219b0dcff3e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>ASCORBIC ACID</topic><topic>LABORATORY ANIMALS</topic><topic>LIVER DISEASES</topic><topic>Penicillin</topic><topic>PENICILLINS</topic><topic>RETINOL</topic><topic>SIDE EFFECTS</topic><topic>Streptomycin</topic><topic>THERAPY</topic><topic>VITAMINS</topic><topic>أمراض الكبد</topic><topic>الأعراض الجانبية</topic><topic>البنسلين</topic><topic>البنسلينات</topic><topic>التغذية</topic><topic>الرتنول</topic><topic>العلاج</topic><topic>الفيتامينات</topic><topic>المواد المضادة للبكتيريا</topic><topic>حمض الأسكوربيك</topic><topic>حيوانات المختبر</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Eryani , Mohammed A. Y</creatorcontrib><creatorcontrib>Shediwah , Fatma M. H</creatorcontrib><creatorcontrib>Al-Shaibani , Elham A. S</creatorcontrib><creatorcontrib>Salih , Elias M. A</creatorcontrib><creatorcontrib>Al-Awar , Mohammed S. A</creatorcontrib><collection>Al Manhal All Journals Collection</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>CrossRef</collection><jtitle>Jordan journal of biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Eryani , Mohammed A. Y</au><au>Shediwah , Fatma M. H</au><au>Al-Shaibani , Elham A. S</au><au>Salih , Elias M. A</au><au>Al-Awar , Mohammed S. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Ability of Vitamin a , Alone or in Combination with Vitamins C and E , in Ameliorating the Side Effects of Penicillin and Streptomycin on Hepatic Damage in Guinea Pigs</atitle><jtitle>Jordan journal of biological sciences</jtitle><date>2014</date><risdate>2014</risdate><volume>7</volume><issue>2</issue><spage>127</spage><epage>132</epage><pages>127-132</pages><issn>1995-6673</issn><abstract>The administration of vitamin A (10000 IU/kg b.w), vitamin A, C and E (10000 IU/kg, 100 mg/kg 100 mg/kg b.w),
penicillin (50000 IU/kg b.w), penicillin + vitamin A, penicillin + vitamin A, C and E, streptomycin (50 mg/kg b.w),
streptomycin + vitamin A, streptomycin + vitamins A, C and E for 30 days caused a significant increase in the levels of
AST, ALT and ALP, and also caused a significant decrease in the levels of total protein and albumin in penicillin and
streptomycin treated groups. However, co-administration of penicillin and streptomycin with vitamin A alone or in
combination with vitamins C and E ameliorated the harmful effects of penicillin and streptomycin in most of the tested
parameters. Vitamin A, either alone or in combination with vitamin C and E, has a protective effect on the histological
changes of liver tissues induced either by penicillin or streptomycin administration. The result of the present work reveals
for the first time that vitamin A alone or in combination with vitamin C and E plays an important role as cytoprotective
compounds on hepatic damage in guinea pigs. Hence, further studies on the possible uses of vitamins as protective
compounds during treatment with antibiotics are needed.</abstract><cop>Az Zarqa' - Jordan</cop><pub>The Hashemite University : The Deanship of Scientific Research and Graduate Studies</pub><doi>10.12816/0008226</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1995-6673 |
| ispartof | Jordan journal of biological sciences, 2014, Vol.7 (2), p.127-132 |
| issn | 1995-6673 |
| language | eng |
| recordid | cdi_almanhal_primary_56274 |
| source | EZB-FREE-00999 freely available EZB journals |
| subjects | ASCORBIC ACID LABORATORY ANIMALS LIVER DISEASES Penicillin PENICILLINS RETINOL SIDE EFFECTS Streptomycin THERAPY VITAMINS أمراض الكبد الأعراض الجانبية البنسلين البنسلينات التغذية الرتنول العلاج الفيتامينات المواد المضادة للبكتيريا حمض الأسكوربيك حيوانات المختبر |
| title | The Ability of Vitamin a , Alone or in Combination with Vitamins C and E , in Ameliorating the Side Effects of Penicillin and Streptomycin on Hepatic Damage in Guinea Pigs |
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