Practical Application of Oxidation Using a Novel Na2WO4−H2O2 System under Neutral Conditions for Scale-Up Manufacturing of 12α-Hydroxy-3-oxooleanano-28,13-lactone: Key Intermediate of Endothelin A Receptor Antagonist S-0139

Novel alcohol oxidation using a Na2WO4−H2O2 system was applied to manufacture 12α-hydroxy-3-oxooleanano-28,13-lactone which is a key intermediate of S-0139. Oxidation of the hydroxyl group of oleanolic acid was optimized based on the design of experiment (DoE) approach. Statistical analysis was used...

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Veröffentlicht in:	Organic process research & development 2010-01, Vol.14 (1), p.289-294
Hauptverfasser:	Hida, Takemasa, Fukui, Yuuki, Kawata, Kyozo, Kabaki, Mikio, Masui, Toshiaki, Fumoto, Masataka, Nogusa, Hideo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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